SPECT/CT for Molecular Imaging Facility at TJU

TJU 分子成像设备 SPECT/CT

• 批准号: 8628246
• 负责人: MATHEW laxman THAKUR
• 金额: $ 30.04万
• 依托单位: THOMAS JEFFERSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-27 至 2015-09-26
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8628246
• 关键词: 4 year old; Animals; Basic Science; Biomedical Research; Cardiology; Cost Control; Data; Diagnosis; Disease; Docking; Doctor of Philosophy; Drug Kinetics; Effectiveness; Enrollment; Equipment; Funding; Image; Imaging Device; Investigation; Journals; Letters; Magnetic Resonance Imaging; Modality; Neurology; Optics; Peer Review; Physicians; Positron-Emission Tomography; Prevention; Radiology Specialty; Research Personnel; Research Project Grants; Resolution; Scientist; Services; System; Therapeutic Intervention; Translational Research; Ultrasonography; in vivo; molecular imaging; novel; oncology; operation; optical imaging; single photon emission computed tomography

DESCRIPTION (provided by applicant): The importance of imaging small animals in basic and translational biomedical research, with such modalities as PET, SPECT, CT, optical, ultrasound and MRI, cannot be overemphasized. The ability to image small animals without having to sacrifice a large number of them allows investigators to a) validate novel probes for diagnosis and therapy, b) conduct pharmacokinetic studies in vivo, c) evaluate investigational bio- molecules for prevention and treatment of diseases, and d) determine the effectiveness of therapeutic interventions. Small animal imaging reduces the number of animals to be enrolled in each investigation, controls cost, and provides valuable, scientifically valid data that can be evaluated statistically. At TJU, more than three hundred basic and physician scientists are engaged in biomedical research in oncology, neurology and cardiology. In 2004, TJU established a small animal imaging facility that is directed by the PI (Mathew L. Thakur, PhD), in the Department of Radiology. The facility includes a CT, PET/SPECT, a PET scanner and an optical imaging device. This facility has thus far been used by thirty-seven investigators and produced sixty four articles in peer-reviewed journals. CT is an integral part of PET/SPECT imaging. The four-year-old MicroCAT II CT we are currently using breaks down frequently. Even worse, Siemens service is not available as of January 1, 2012 (letter dated August 1, 2011). Our SPECT equipment is a modified Philips MOSAIC PET unit that suffers from poor resolution and presents numerous technical challenges for its operation in the SPECT mode. The availability of the Siemens SPECT/CT unit that can dock to our existing Siemens Inveon PET will provide us with a highly versatile, integrated, tri-modal imaging system that shall greatly enhance our imaging capability and serve for several federally funded translational and basic research projects at TJU. No such system currently exists at TJU. (1)

描述（由申请人提供）：小动物成像在基础和转化生物医学研究中的重要性，如PET， SPECT， CT，光学，超声和MRI，怎么强调都不为过。在不牺牲大量动物的情况下对小动物进行成像的能力使研究人员能够a)验证用于诊断和治疗的新探针，b)进行体内药代动力学研究，c)评估用于预防和治疗疾病的研究性生物分子，以及d)确定治疗干预措施的有效性。小动物成像减少了每次调查中登记的动物数量，控制了成本，并提供了有价值的、科学有效的数据，可以进行统计评估。在TJU，有300多名基础和内科科学家从事肿瘤学、神经病学和心脏病学的生物医学研究。2004年，TJU在放射学系建立了一个由PI （Mathew L. Thakur博士）领导的小动物成像设施。该设施包括CT， PET/SPECT， PET扫描仪和光学成像设备。到目前为止，已有37名研究人员使用了该设备，并在同行评议的期刊上发表了64篇文章。CT是PET/SPECT成像的重要组成部分。我们目前使用的使用了四年的MicroCAT II CT经常发生故障。更糟糕的是，截至2012年1月1日（2011年8月1日的信函），西门子的服务还不可用。我们的SPECT设备是一种改良的飞利浦马赛克PET单元，其分辨率较差，在SPECT模式下的操作面临许多技术挑战。西门子SPECT/CT单元的可用性可以与我们现有的西门子Inveon PET对接，这将为我们提供一个高度通用的、集成的、三模式的成像系统，这将大大提高我们的成像能力，并为TJU的几个联邦资助的转化和基础研究项目服务。TJU目前没有这样的系统。（1)