PREVENTION-CONTROL

项目总结(见说明)： 癌症预防和控制计划(PC)的成员开展人口科学和化学预防研究，这对减轻科罗拉多州、落基山地区和其他地区的癌症负担具有重大潜力。PC有三个主要关注点：1)一级和二级预防的行为研究，2)化学预防研究，以及3)癌症结局和癌症存活率研究。在目前的CCSG计划期间，成员们对科学做出了许多贡献 癌症预防和控制，包括：1)几个大型研究临床试验(RCT)，证明了量身定制的印刷材料促进水果和蔬菜消费、结直肠癌筛查和戒烟的有效性；2)以学校为基础的大型计划和针对户外冬季娱乐行业的重大努力，成功地促进了防晒；3)强大的实验室研究计划，证明了水飞蓟宾对动物的化学预防特性 前列腺癌、肺癌、结直肠癌和膀胱癌的模型，以及治疗前列腺癌和结肠癌的葡萄籽提取物；4)一项大型的多地点随机对照试验，展示电话咨询对乳腺癌幸存者的心理社会结果的有效性；5)一项大型的多地点随机对照试验，证明儿童癌症幸存者的认知补救计划的有效性；6)癌症流行病学研究中最具权威性的两个项目，研究并确定了乳腺癌的危险因素。 在拉丁裔美国人和科罗拉多州幼儿中的雀斑发展，以及7)在防晒、饮食、营养和体力活动、烟草控制、结直肠癌筛查和化学预防研究等领域的翻译科学和传播研究的众多范例。PC包括31名正式成员和32名准成员，他们来自科罗拉多大学丹佛大学、科罗拉多大学博尔德大学、退伍军人管理局(丹佛)、 科罗拉多州立大学、丹佛健康医疗中心、儿童医院(丹佛)和科罗拉多州凯撒永久医院。在当前的CCSG期间，计划成员发表了594篇同行评议的癌症相关论文，而在前一次CCSG期间发表了306篇。其中37%是协作性出版物，23%是方案间出版物或方案间和方案内出版物。经过同行评审，与癌症相关的资金也从2005年的890万美元增加到2010年的1330万美元。这意味着每个成员的人均价值从26.9万美元增加到64万美元以上，增幅为140%。

PROJECT SUMMARY (See instructions): Members of the Cancer Prevention and Control Program (PC) conduct population sciences and chemoprevention research that has significant potential to reduce the cancer burden in Colorado, the Rocky Mountain Region and beyond. PC has three main focus groups: 1) behavioral research in primary and secondary prevention, 2) chemoprevention research, and 3) cancer outcomes and cancer survivorship research. During the current CCSG program members have made numerous contributions to the science of cancer prevention and control, including: 1) several large research clinical trials (RCTs) that have demonstrated the efficacy of tailored print materials to promote fruit and vegetable consumption, colorectal cancer screening and smoking cessation; 2) a large school-based program and a monumental effort that targeted the outdoor winter recreation industry that successfully promoted sun protection; 3) a robust program of laboratory research that has demonstrated the chemoprevention properties of silibinin in animal models for prostate, lung, colorectal, and bladder cancer, as well as grape seed extract for prostate and colon cancer; 4) a large multi-site RCT demonstrating the efficacy of telephone counseling on psychosocial outcomes among breast cancer survivors; 5) a large multi-site RCT that demonstrated the efficacy of a cognitive remediation program for young survivors of childhood cancer; 6) two of the most definitive programs of research in cancer epidemiology that have examined and identified risk factors for breast cancer among Latinas, and nevus development among young children in Colorado, and 7) numerous exemplars of translational science and dissemination research in the areas of sun protection, diet, nutrition and physical activity, tobacco control, colorectal cancer screening and chemoprevention research. PC includes 31 Full Members and 32 Associate Members drawn from 17 academic departments and schools within the University of Colorado Denver, University of Colorado Boulder, the Veterans Administration (Denver), Colorado State University, Denver Health Medical Center, The Children's Hospital (Denver) and Kaiser Permanente of Colorado. During the current CCSG, program members have published 594 peer-reviewed cancer-related papers, compared to 306 during the previous CCSG. 37% of these publications were collaborative, with 23% being interprogrammatic or both interprogrammatic and intraprogrammatic. Peer reviewed, cancer-related funding has also increased from $8.9M (2005) to $13.3M in 2010. This represents a per capita increase of 140% from $269K to over $640K per member.