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申请者描述(由申请人提供)：本申请请求部分资助将于2014年6月1-6日在伊利诺伊州伊塔斯卡举行的第17届美国实验生物学学会联合会(FASE B)关于维甲酸的夏季研究会议。这个每两年举行一次的研究会议出席人数非常多(在过去30年中，出席人数从100到200人不等)，并且仍然是唯一一次涉及维甲酸生物学全光谱的主要国内和国际会议。随着对维甲酸作用机制和生物学功能的深入研究，人们越来越需要了解和应用维甲酸在人类营养和疾病中的作用。目前，大量正在进行的研究活动得到了NIH的支持(NIH报告数据库表明，目前有1,460项由NIH资助的涉及类维A/维生素A生物学的个人研究资助)。2014年会议将以一个新的“圆桌会议”小组开始，由该领域的几名高级调查人员提供全面和历史的观点。随后将举行8次座谈会、2次传统邮寄会议和1次新的“海报奖”，并结合新的“会见专家”会议闭幕。其目标是促进新研究成果的交流。特别是，我们的目标是鼓励新的/年轻的研究人员与这一领域的资深研究人员会面和建立联系，并促进纳入其他相关领域的科学家和临床医生的新见解/想法/技术。会议将讨论的主要议题包括维甲酸生物学的基本和翻译方面：(1)维甲酸代谢；(2)维甲酸酶学；(3)维甲酸信号；(4)维甲酸与发育和干细胞生物学；(5)维甲酸与疾病I-癌症；(6)维甲酸与疾病II--免疫和新陈代谢；(7)疾病III-眼睛和神经系统中的维甲酸；(8)维甲酸和类胡萝卜素化学生物学。总的目标是聚集一群研究人员(高级科学家、职业中期科学家、初级科学家、博士后研究员和研究生)，他们在不同的学科工作(作为生物化学家、分子生物学家、营养学家、癌症研究人员、视觉研究人员、干细胞生物学家、生物物理学家、结构生物学家、免疫学家、化学家和临床医生)，展示和讨论他们对维甲酸类化合物的共同关注的最新研究成果。这次会议将提供一个论坛，对最近的研究进行批判性审查，并将新开发的想法和技术纳入这一经典主题的翻译前沿。这将使新的研究能够为维甲酸在预防疾病和维持健康以及开发新疗法方面的应用提供必要的洞察力，并促进基础科学家和临床医生之间的合作。

DESCRIPTION (provided by applicant): This application requests partial support for the 17th Federation of American Societies for Experimental Biology (FASEB) Summer Research Conference on Retinoids to be held at Itasca, Illinois on June 1-6, 2014. This bi- annual research conference has been very well attended (ranging from 100 to 200 attendees over the past 30 years) and remains the sole major national and international conference that addresses the full spectrum of retinoid biology. While the mechanisms of action and the biological functions of retinoids have been intensively studied, there is an increasing need in understanding and applying retinoids in human nutrition and diseases. Currently, a great deal of ongoing research activity is supported by the NIH (the NIH RePORT database indicates that there are currently 1,460 NIH funded individual research grants involving retinoid/vitamin A biology). The 2014 conference will start with a new "Round Table" panel providing a holistic and historical view by several senior investigators in the field. This will be followed by 8 symposia, 2 traditional poste sessions, and one new "Poster Award" in conjunction with a new "Meet the Expert" session to close the meeting. The goal is to foster the exchange of new research findings. In particular, we aim to encourage new/young investigators meeting and networking with senior investigators in this field, and facilitate the inclusion of new insights/ideas/techniques from scientists and clinicians in other related fields. The main topics to be addressed at the conference include both basic and translational fronts of retinoid biology: (1) retinoid metabolism; (2) retinoid enzymology; (3) retinoid signaling; (4) retinoids in development and stem cell biology; (5) retinoids in disease I - cancers; (6) retinoids in disease II - immunity and metabolism; (7) retinoids in disease III - eyes and the nervous systems; (8) retinoids and carotenoid chemical biology. The overall goal is to bring together a group of investigators (senior scientists, mid-career scientists, junior scientists, postdoctoral fellows, and graduate students) who work in diverse disciplines (as biochemists, molecular biologists, nutritional scientists, cancer researchers, vision researchers, stem cell biologists, biophysicists, structural biologists, immunologists, chemists, and clinicians) to present and discuss their newest research findings that share a common focus on the retinoids. This conference will provide a forum for critical review of recent research and incorporation of newly developed ideas and technologies into translational fronts of this classical topic. This will allow new investigations to provide needed insight into the applications of retinoids in preventing disease and maintaining health and in developing new therapeutics, and facilitate collaborations among basic scientists and clinicians.