Testing a Promising Treatment for Youth Substance Abuse in a Community Setting

在社区环境中测试一种有前景的治疗青少年药物滥用的方法

• 批准号: 8733141
• 负责人: Scott W Henggeler
• 金额: $ 65.48万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-15 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8733141
• 关键词: Address; Adolescent; Adopted; Adoption; Adult; Alcohol or Other Drugs use; Attitude; Behavior; Behavioral; Characteristics; Clinical; Clinical effectiveness; Cognitive; Communities; Complex; Development; Diagnostic; Diffusion; Diffusion of Innovation; Drug Courts; Drug usage; Effect Modifiers (Epidemiology); Effectiveness; Effectiveness of Interventions; Evidence based treatment; Family; Funding; Goals; Imprisonment; Institute of Medicine (U.S.); Intervention; Legal; Link; Literature; Measures; Mediator of activation protein; Mental Health; Modeling; National Institute of Drug Abuse; Outcome; Outpatients; Parenting behavior; Participant; Pharmaceutical Preparations; Psychological reinforcement; Public Health; Public Sector; Randomized; Relative (related person); Reporting; Research; Research Personnel; Rewards; Science; Self Management; Self-control as a personality trait; Services; Substance Addiction; Substance Use Disorder; Substance abuse problem; Supervision; Symptoms; Testing; Validation; Youth; adolescent substance abuse; adolescent substance use; anti social; base; community based treatment; community setting; contingency management; cost; cost effectiveness; court personnel; criminal behavior; deviant; dissemination research; drug testing; drug use screening; dual diagnosis; experience; follow-up; implementation research; interest; meetings; peer; public health relevance; randomized trial; skills training; substance abuse treatment; treatment as usual; treatment center

DESCRIPTION (provided by applicant): The overriding purpose of the proposed randomized trial is to examine the effectiveness of a promising and efficient outpatient treatment of adolescent substance abuse delivered in a community-based treatment setting. Although several evidence-based treatments of adolescent substance abuse are emerging (see e.g., Waldron & Turner, 2008), none have experienced widespread adoption in community settings. Thus, as noted by the Institute of Medicine (1998) more than a decade ago and reiterated more recently (e.g., McCarty et al., 2007), a considerable science-service gap exists in regards to treatment of substance abuse in adolescents and adults. For the proposed study, 204 adolescents meeting diagnostic criteria for substance abuse or dependence will be randomized to either the Contingency Management-Family Engagement (CM-FAM; Henggeler et al., 2012) or Treatment as Usual (TAU) conditions. A multimethod, multirespondent approach will be used to track clinical outcomes at 3, 6, 9, 12, and 18 months post recruitment. Clinical level outcomes pertain to youth substance use, criminal behavior, mental health functioning, and key mediators of serious antisocial behavior in adolescents (e.g., self-control, parental supervision, associatio with deviant peers). In addition, the incremental cost of CM-FAM will be determined for use in cost effectiveness analyses. Aim 1: Over an 18-month post-recruitment follow-up, determine the relative effectiveness of CM-FAM vs. TAU in reducing adolescent participants' substance use, criminal activity (including incarceration), and mental health symptoms; and evaluate the cost effectiveness of CM-FAM in achieving these outcomes. Aim 2: Examine possible moderators and mediators of intervention effectiveness. Moderator variables will include youth demographic and clinical (e.g., co-occurring disorders) characteristics. Mediator variables will include measures of self-control, parenting, and association with deviant peers - constructs targeted by CM- FAM.

描述（由申请人提供）：拟议的随机试验的首要目的是检查一个有前途的和有效的门诊治疗青少年药物滥用的有效性，在社区为基础的治疗设置。虽然青少年药物滥用的几种循证治疗方法正在出现（见例如，沃尔德龙和特纳，2008年），没有经历过广泛采用的社区设置。因此，正如医学研究所（1998年）在十多年前指出并在最近重申的那样（例如，McCarty等人，2007年），在青少年和成人药物滥用治疗方面存在相当大的科学服务差距。 对于拟议的研究，204名符合物质滥用或依赖诊断标准的青少年将被随机分配到应急管理-家庭参与（CM-FAM; Henggeler等人，2012年）或治疗为糖尿病（TAU）条件。将使用多方法、多应答方法跟踪招募后3、6、9、12和18个月的临床结局。临床水平的结果涉及青少年物质使用、犯罪行为、心理健康功能和青少年严重反社会行为的关键介质（例如，自我控制，父母监督，与越轨同伴的交往）。此外，将确定CM-FAM的增量成本，用于成本效益分析。 目标1：在招募后的18个月随访中，确定CM-FAM与TAU在减少青少年参与者的物质使用，犯罪活动（包括监禁）和心理健康症状方面的相对有效性;并评估CM-FAM在实现这些结果方面的成本效益。 目标2：研究干预有效性的可能调节者和调解者。调节变量将包括青年人口统计学和临床（例如，共同发生的疾病）特征。中介变量将包括自我控制的措施，养育，并与越轨的同龄人-CM-FAM针对的结构。