Folate targeted intraoperative cancer imaging to guide pulmonary resections

叶酸靶向术中癌症成像指导肺切除术

• 批准号: 8702707
• 负责人: Sunil Singhal
• 金额: $ 8万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8702707
• 关键词: Address; Adenocarcinoma; Animals; Applications Grants; Biomedical Engineering; Cancer Detection; Cancer Patient; Canis familiaris; Chest; Clinical; Clinical Trials; Collaborations; Commit; Companions; Contrast Media; Data; Detection; Development; Devices; Disease; Drainage procedure; Drug Kinetics; Dyes; Enrollment; Ensure; Excision; Eye; Folate; Future; Goals; Hand; Human; Image; Image-Guided Surgery; Left; Lung; Lung Adenocarcinoma; Lung Neoplasms; Lymph Node Mapping; Lymphatic; Malignant - descriptor; Malignant Neoplasms; Malignant neoplasm of lung; Malignant neoplasm of ovary; Maps; Measurement; Metastatic Lesion; Micrometastasis; Modeling; Modification; Neoplasm Metastasis; Nodule; Noise; Operating Rooms; Operative Surgical Procedures; Optics; Outcome; Parathyroid Adenoma; Patients; Penetration; Pilot Projects; Primary Neoplasm; Property; Recurrence; Renal Cell Carcinoma; Resected; Residual Cancers; Residual Neoplasm; Residual Tumors; Residual state; Robotics; Signal Transduction; Solid; Solid Neoplasm; Surgeon; Surgical Models; Surgical margins; Tactile; Technology; Testing; Time; Tissues; Toxicology; Tracer; Translating; Tumor Biology; United States; Work; base; breast carcinoid tumor; cancer care; cancer cell; cancer imaging; cancer surgery; design; folate-binding protein; human tissue; improved; innovation; innovative technologies; instrumentation; intraoperative imaging; light intensity; lymph nodes; new technology; operation; optical imaging; outcome forecast; pre-clinical; prevent; public health relevance; tool; tumor

DESCRIPTION (provided by applicant): The primary goal of this pilot canine clinical trial is to translate revolutionary imaging agents for intraoperative cancer detection and image-guided surgery. Half of all cancer patients, over 700,000 annually in the US, undergo surgery to remove their tumor. The single most important predictor of patient survival is a complete surgical resection of the primary tumor, draining lymph nodes, and metastatic lesions. However, up to 40% of surgical patients leave the operating room with malignant cells remaining after resection. Thus, there are urgent unmet needs to develop new and innovative technologies that can assist the surgeon in ensuring complete tumor resection by delineating tumor margins, and identifying micrometastases and draining lymph nodes. We propose a new technology to image patients at the conclusion of the standard-of-care cancer operation in order to discover residual local disease before completing the surgery. While the proposed technologies are broadly applicable to solid tumors, this project is specifically committed to improving detection of lung adenocarcinomas, one of the most aggressive human malignancies. The proposed work will optimize a near-infrared folate targeted contrast agent and translate an intraoperative imaging approach. The folate-near infrared dye contrast agent will be optimized in a canine surgical model for spontaneous lung cancer.

描述（由申请人提供）：这项试点犬临床试验的主要目标是将革命性的成像剂用于术中癌症检测和图像引导手术。在美国，每年有超过70万的癌症患者接受手术切除肿瘤。患者生存的唯一最重要的预测因素是原发肿瘤、引流淋巴结和转移灶的完全手术切除。然而，高达40%的手术患者离开手术室时，切除后仍有恶性细胞残留。因此，迫切需要开发新的和创新的技术，这些技术可以帮助外科医生通过描绘肿瘤边缘和识别微转移和引流淋巴结来确保完全的肿瘤切除。我们提出了一种新的技术，在标准护理癌症手术结束时对患者进行成像，以便在完成手术之前发现残留的局部疾病。虽然所提出的技术广泛适用于实体瘤，但该项目特别致力于改善肺腺癌的检测，肺腺癌是最具侵袭性的人类恶性肿瘤之一。拟议的工作将优化近红外叶酸靶向造影剂和翻译术中成像方法。叶酸-近红外染料造影剂将在自发性肺癌的犬手术模型中进行优化。