Intraoperative Near Infrared Molecular Imaging of Lung Cancer

肺癌术中近红外分子成像

• 批准号: 10333063
• 负责人: Sunil Singhal
• 金额: $ 163.81万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-16 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10333063
• 关键词: Achievement; Address; Affect; American; Attention; Biopsy; Bronchoscopes; Bronchoscopy; Cancer Patient; Clinical; Clinical Trials; Complex; Computer software; Contrast Media; Data; Development; Devices; Diagnosis; Diagnostic; Diagnostic Procedure; Disease; Dyes; Endoscopes; Endoscopy; Equipment; Excision; Faculty; Failure; Goals; Grant; Healthcare; Image; Image-Guided Surgery; Imaging Device; Imaging technology; Individual; Joints; Lead; Libraries; Life; Light; Lung nodule; Malignant Neoplasms; Malignant neoplasm of lung; Methodology; Molecular; Molecular Target; Near-infrared optical imaging; Nodule; Non-Small-Cell Lung Carcinoma; Operative Surgical Procedures; Optics; Outcome; Patient Care; Patient-Focused Outcomes; Patients; Persons; Polyps; Procedures; Protocols documentation; Publications; Research; Robotics; Science; Staging; Technology; Testing; Therapeutic; Therapeutic procedure; Tracer; Translating; United States National Institutes of Health; Validation; Work; bench to bedside; cancer surgery; clinical translation; data management; design; efficacy trial; experience; first-in-human; flexibility; human imaging; imaging platform; improved; improved outcome; innovation; lymph nodes; molecular imaging; neoplastic cell; optical imaging; programs; skills; small molecule; standard of care; success; surgery outcome; tumor; tumor microenvironment

Project Summary/Abstract Non-small cell lung cancer (NSCLC) is a devastating disease with a poor outcome. When a patient is first diagnosed with NSCLC, the person would typically undergo diagnostic bronchoscopy and/or therapeutic surgery. These two procedures have technical challenges that limit their success such as inaccurate biopsies, failure to locate nodules and lymph nodes, missed occult tumors, and positive margins. As a consequence, there is a 40% failure rate for these procedures. This Project will use optical imaging in the near-infrared (NIR) range to generate practical solutions to these problems and make these two common procedures safer, more efficient, and have improved outcomes. The goal of this Project is to test the hypothesis that intraoperative imaging in the NIR spectrum with targeted molecular tracers can identify tumor cells in order to improve procedures that are utilized for the management of patients with NSCLC. The innovation of this Program Project will be in the matrix of cocktail dye development, new NIR camera devices, and clinical translation. There are three specific goals of this Project. First, to develop a set of targeted near-infrared molecular imaging contrast agents that are sensitive and specific to a range of distinct targets on NSCLC. Second, to develop and integrate highly NIR spectral sensitive imaging platforms into commonly used white light imaging devices so they can be utilized during clinical procedures. And third, to apply these innovations to solve common clinical problems in order to impact patient care. If successful, the molecular optical imaging solution presented in this proposal would be immediately applicable to several hundred thousand lung cancer patients each year.

项目摘要/摘要 非小细胞肺癌（NSCLC）是一种毁灭性疾病，预后较差。当病人是 该人首先被诊断为NSCLC，通常会进行诊断支气管镜检查和/或 治疗手术。这两个程序面临技术挑战，可以限制他们的成功，例如 不准确的活检，未能定位结节和淋巴结，丢失的神秘肿瘤和阳性 利润。结果，这些程序的故障率为40％。这个项目将使用 近红外（NIR）范围内的光学成像，以生成这些问题的实用解决方案 使这两个常见的程序更安全，更有效，并改善了结果。目标 该项目是为了检验以下假设：靶向有针对性的NIR光谱中的术中成像 分子示踪剂可以鉴定肿瘤细胞，以改善用于 NSCLC患者的管理。该计划项目的创新将在 鸡尾酒染料开发，新的NIR相机设备和临床翻译。有三个特定的 这个项目的目标。首先，开发一组靶向的近红外分子成像对比剂 对NSCLC上的一系列不同目标敏感且具有特异性。第二，开发和整合 高度NIR光谱敏感的成像平台进入常用的白光成像设备，因此 可以在临床过程中使用。第三，应用这些创新来解决常见的临床 问题以影响患者护理。如果成功，则呈现分子光学成像溶液 在此提案中，将立即适用于数十万肺癌患者 每年。