Geroscience Network

老年科学网络

• 批准号: 8738561
• 负责人: JAMES L. KIRKLAND
• 金额: $ 23.25万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8738561
• 关键词: Address; Affect; Age; Aging; Agreement; Animal Model; Animals; Applications Grants; Area; Arkansas; Arthritis; Atherosclerosis; Bilateral; Biology of Aging; Blindness; Caloric Restriction; Cells; Chronic Disease; Clinic; Clinical; Clinical Trials; Clinical Trials Network; Collaborations; Consensus; Dementia; Development; Diabetes Mellitus; Disease; Educational Curriculum; Equipment and supply inventories; European; Event; Faculty; Funding; Gene Mutation; Geroscience; Goals; Grant; Growth Hormone Receptor; Health; Health Care Costs; Health Sciences; Human; Human Resources; Individual; Institutes; Institution; Intervention; Invertebrates; Joints; Kidney Diseases; Laboratories; Life; Link; Longevity; Longitudinal Studies; Malignant Neoplasms; Mammals; Measurable; Measurement; Medicine; Metabolic syndrome; Michigan; Minnesota; Monoclonal Antibody R24; Morbidity - disease rate; Mus; Mutation; Osteoporosis; Paper; Pathway interactions; Policies; Population; Population Study; Preparation; Process; Protocols documentation; Publications; Research Infrastructure; Research Personnel; Resources; Risk; Risk Factors; Scientist; Sirolimus; Stem cells; Stress; Testing; Texas; Time; Tissues; Translating; Translations; United States; Universities; Washington; Work; age related; base; bench to bedside; clinical application; college; cost; design; disability; effective therapy; forest; frailty; human subject; innovation; insight; juvenile animal; medical schools; modifiable risk; mouse model; pre-clinical; prevent; programs; senescence; therapeutic target; trait; translational study; working group

DESCRIPTION (provided by applicant): Chronic diseases are the leading cause of morbidity and the major driver of health costs in the US. Aging is the leading risk factor for nearly all majr chronic diseases. Recent insights support the possibility that aging may be a modifiable risk factor. We hypothesize that by targeting fundamental mechanisms of aging, clinical interventions can be envisaged that could delay or prevent age-related diseases and disabilities as a group, rather than one at a time. We propose the following Specific Aims. Aim 1. Establish a national interdisciplinary network of aging centers as the basis for a Geroscience Network to understand and exploit links between aging and genesis of chronic disease. Initial partners will include geriatricians and basic scientists from Mayo Clinic, Buck Institute, Barshop Institute, Albert Einstein College of Medicine, Stanford, Harvard, Johns Hopkins, and Wake Forest Universities, and the Universities of Washington, Arkansas, Minnesota, and Michigan. By planning and working in a coordinated way through the Geroscience Network, we intend to accelerate development and translation of effective treatments to delay or prevent age-related disabilities and diseases. Aim 2. Use retreats to initiate planning for strategies, translational paradigms, curricula, and other resources needed to test our hypothesis. To begin developing the strategies, personnel, and infrastructure necessary, we will delineate the strengths of each center, identify gaps and areas of overlap, and develop consensus about areas of focus. Aim 3. Use faculty exchanges to bring together working groups to complete white papers, publications, and grants based on strategies and translational paradigms initiated during the retreats, continue planning for clinical trials networks, and develop curricula for developing personnel needed for translation of interventions arising from the basic biology of aging into clinical applications. These innovative approaches will allow us to translate findings from bench to bedside more rapidly than possible by individual centers, laboratories, and groups of geriatricians.

描述（由申请人提供）：慢性病是美国发病的主要原因，也是健康成本的主要驱动因素。衰老是几乎所有主要慢性疾病的主要危险因素。最近的见解支持衰老可能是一个可改变的风险因素的可能性。我们假设，通过针对衰老的基本机制，可以设想临床干预措施可以延迟或预防与年龄相关的疾病和残疾作为一个整体，而不是一次一个。我们提出以下具体目标。目标 1. 建立一个全国老龄化中心跨学科网络，作为老年科学网络的基础，以了解和利用老龄化与慢性病发生之间的联系。最初的合作伙伴将包括来自梅奥诊所、​​巴克研究所、巴肖普研究所、阿尔伯特·爱因斯坦医学院、斯坦福大学、哈佛大学、约翰·霍普金斯大学、维克森林大学以及华盛顿大学、阿肯色大学、明尼苏达大学和密歇根大学的老年病学家和基础科学家。通过老年科学网络以协调的方式进行规划和工作，我们打算加速有效治疗方法的开发和转化，以延缓或预防与年龄相关的残疾和疾病。目标 2. 利用静修活动启动策略、转化范式、课程和其他验证我们的假设所需的资源的规划。为了开始制定必要的战略、人员和基础设施，我们将描绘每个中心的优势，找出差距和重叠领域，并就重点领域达成共识。目标 3. 利用教师交流将工作组聚集在一起，根据务虚会期间发起的战略和转化范式完成白皮书、出版物和资助，继续规划临床试验网络，并开发课程以培养将衰老基础生物学干预措施转化为临床应用所需的人员。这些创新方法将使我们能够比各个中心、实验室和老年病学家小组更快地将研究结果从实验室转化为临床。