Chlorine Dioxide Gas Generators for Equipment and Room Sterilization

首席调查员/项目主任(最后、第一、中间)：Criley，Jennifer，M 项目摘要/摘要 伊利诺伊大学香槟分校(UIUC)寻求资金购买两(2) 便携式二氧化氯气体发生器，用于消毒专门的啮齿动物测试设备和 位于校园各处的实验动物收容所。使用这种消毒设备来 特效灭鼠鼠细小病毒(MPV、RPV、RMV)环境 污染将直接影响18名首席调查人员的研究，并间接 整个UIUC实验室动物护理项目。这18名主要调查人员对 目前正在进行的和尚未完成的研究支出总额分别为1900万美元和4490万美元。 目前，UIUC所有生物医学研究支出总额为1.1亿美元(现役)和268美元 百万美元(待定)。 有专门的住房和测试设备在使用，这使得传统的方法 设备的卫生不可行。大型设备和设备安装在 房间必须就地消毒，最好的方法是用灭菌剂在室内消毒 真正的气体形式-允许多种配置中的多种成分渗透。这 只能通过便携式二氧化氯发生器来完成。 通过消除啮齿动物群体中的外来病原体(如MPV、RPV、RMV)， UIUC生物医学研究将通过以下方式得到显著加强：1)减少研究变量(即 病原体的引进)，2)扩大校园、共享、核心设施和 服务(如成像中心、麻醉设备等)，3)促进独特的 和与同行机构有价值的啮齿类动物线路，4)使动物住所能够更有效地使用 通过减少分隔“干净”和“肮脏”动物所需房间的数量和5) 允许更有效地使用人员，从而通过简化交通来降低劳动力成本 模式和其他遏制措施。 PI项目是美国实验动物医学院的文凭，已经 在设计和实施啮齿动物生物安全计划方面有广泛的培训和经验。 此外，PI和本申请表上列出的其他专业人员具有兽医， 对将受此影响的动物设施的管理和运营监督 格兰特。 UIUC每年投资超过1500,000美元直接支持其实验动物/生物医学 研究计划。这笔资金用于支付人员工资、翻新/维护、设备 支出和支持核心设施(例如转基因小鼠和多克隆抗体 生产单位)。按日计算，主动补助金的支出每年再产生1,380,000美元 为我们的实验动物护理和使用项目提供资金。 该项目的范围不会对环境产生负面影响，也不需要 对现有动物设施的任何翻新或修改。职业健康与安全 将解决问题，以确保安全和有效地使用消毒二氧化氯气体 发电机。

Principal Investigator/Program Director (Last, first, middle): Criley, Jennifer, M Project Summary/Abstract The University of Illinois at Urbana-Champaign (UIUC) seeks funding to purchase two (2) portable chlorine dioxide gas generators for sterilizing specialized rodent testing equipment and laboratory animal housing rooms located across campus. The use of this sterilizing equipment to specifically eradicate Mouse and Rat Parvovirus (MPV, RPV, RMV) environmental contamination will directly impact the research of eighteen principal investigators and indirectly the entire UIUC laboratory animal care program. These eighteen principal investigators account for $19 million and $44.9 millon in total active and pending research expenditures, respectively. Currently, biomedical research expenditures for all of UIUC total $110 million (active) and $268 million (pending). There are specialized housing and testing equipment in use which makes traditional methods of sanitation of equipment not feasible. Large equipment and equipment which is mounted in rooms must be sanitized in situ which is best accomplished by sterilization with a sterilant in a true gas form - allowing for permeation of multiple components in multiple configurations. This can only be accomplished by a portable chlorine dioxide generator. Through the elimination of adventitious agents (e.g. MPV, RPV, RMV) in our rodent colonies, UIUC biomedical research will be significantly enhanced by 1) reducing research variables (i.e. introduction of pathogenic agents), 2) expanding the use of on campus, shared, core facilities and services (e.g. imaging center, anesthesia equipment, etc.), 3) facilitating the sharing of unique and valuable rodent lines with peer institutions, 4) enabling more efficient use of animal housing areas by reducing the number of rooms required to segregate "clean" and "dirty" animals and 5) allowing more efficient use of staffing and thus reducing labor costs by simplifying traffic patterns and other containment measures. The Project PI is a Diplomate of the American College of Laboratory Animal Medicine and has extensive training and experience in designing and implementing rodent biosecurity programs. Further, the PI and the other professional personnel listed on this application have veterinary, managerial, and operational oversight of the animal facilities which will be impacted by this grant. UIUC annually invests over $1,500,000 in direct support of its laboratory animal/biomedical research program. This funding targets personnel salaries, renovations/maintenance, equipment expenditures, and support of core facilities (e.g. transgenic mouse and polyclonal antibody production units). Per diem expenditures to active grants produces another $1,380,000 annually to fund our laboratory animal care and use program. The scope of this project does not have a negative impact on the environment nor does it require any renovations or modifications to the existing animal facilities. Occupational health and safety issues will be addressed to ensure safe and efficient use of the sterilizing chlorine dioxide gas generators.