Chlorine Dioxide Gas Generators for Equipment and Room Sterilization

用于设备和房间消毒的二氧化氯气体发生器

• 批准号: 8712960
• 负责人: Jennifer M Criley
• 金额: $ 16.37万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8712960
• 关键词: Accounting; Address; American; Anesthesia procedures; Animal Housing; Animals; Antibody Formation; Area; Biomedical Research; Containment; Core Facility; Ensure; Environment; Environmental Pollution; Equipment; Expenditure; Funding; Gases; Grant; Housing; Human Resources; Illinois; Image; In Situ; Institution; Laboratory Animal Medicine; Laboratory Animals; Maintenance; Measures; Methods; Modification; Mus; Pattern; Principal Investigator; Research; Rodent; Sanitation; Services; Sterilization; Testing; Training; Transgenic Mice; Universities; Wages; animal care; animal facility; biosecurity; chlorine dioxide; college; cost; design; experience; occupational health/safety; peer; polyclonal antibody; programs; rat parvovirus; trafficking

Principal Investigator/Program Director (Last, first, middle): Criley, Jennifer, M Project Summary/Abstract The University of Illinois at Urbana-Champaign (UIUC) seeks funding to purchase two (2) portable chlorine dioxide gas generators for sterilizing specialized rodent testing equipment and laboratory animal housing rooms located across campus. The use of this sterilizing equipment to specifically eradicate Mouse and Rat Parvovirus (MPV, RPV, RMV) environmental contamination will directly impact the research of eighteen principal investigators and indirectly the entire UIUC laboratory animal care program. These eighteen principal investigators account for $19 million and $44.9 millon in total active and pending research expenditures, respectively. Currently, biomedical research expenditures for all of UIUC total $110 million (active) and $268 million (pending). There are specialized housing and testing equipment in use which makes traditional methods of sanitation of equipment not feasible. Large equipment and equipment which is mounted in rooms must be sanitized in situ which is best accomplished by sterilization with a sterilant in a true gas form - allowing for permeation of multiple components in multiple configurations. This can only be accomplished by a portable chlorine dioxide generator. Through the elimination of adventitious agents (e.g. MPV, RPV, RMV) in our rodent colonies, UIUC biomedical research will be significantly enhanced by 1) reducing research variables (i.e. introduction of pathogenic agents), 2) expanding the use of on campus, shared, core facilities and services (e.g. imaging center, anesthesia equipment, etc.), 3) facilitating the sharing of unique and valuable rodent lines with peer institutions, 4) enabling more efficient use of animal housing areas by reducing the number of rooms required to segregate "clean" and "dirty" animals and 5) allowing more efficient use of staffing and thus reducing labor costs by simplifying traffic patterns and other containment measures. The Project PI is a Diplomate of the American College of Laboratory Animal Medicine and has extensive training and experience in designing and implementing rodent biosecurity programs. Further, the PI and the other professional personnel listed on this application have veterinary, managerial, and operational oversight of the animal facilities which will be impacted by this grant. UIUC annually invests over $1,500,000 in direct support of its laboratory animal/biomedical research program. This funding targets personnel salaries, renovations/maintenance, equipment expenditures, and support of core facilities (e.g. transgenic mouse and polyclonal antibody production units). Per diem expenditures to active grants produces another $1,380,000 annually to fund our laboratory animal care and use program. The scope of this project does not have a negative impact on the environment nor does it require any renovations or modifications to the existing animal facilities. Occupational health and safety issues will be addressed to ensure safe and efficient use of the sterilizing chlorine dioxide gas generators.

主要研究者/项目负责人（最后，第一，中间）：Criley，Jennifer，M 项目总结/摘要 伊利诺伊大学厄巴纳-香槟分校（UIUC）寻求资金购买两个（2） 便携式二氧化氯气体发生器，用于对专门的啮齿动物测试设备进行消毒， 实验动物宿舍位于校园各处。使用这种消毒设备， 特异性根除小鼠和大鼠细小病毒（MPV、RPV、RMV）环境 污染将直接影响18名主要研究人员的研究， 整个UIUC实验室动物护理计划。这18位主要研究者 分别为1900万美元和4490万美元的总活动和待定研究支出。 目前，整个UIUC的生物医学研究支出总计1.1亿美元（活跃）和268美元 百万（待定）。 有专门的住房和测试设备的使用，使传统的方法， 设备卫生不可行。大型设备和安装在 房间必须就地消毒，最好是用消毒剂在 真气体形式-允许多种配置中的多种组分的渗透。这 只能通过便携式二氧化氯发生器来实现。 通过消除啮齿动物群落中的外源因子（例如MPV、RPV、RMV）， UIUC生物医学研究将通过1）减少研究变量（即 病原体的引入），2）扩大校园内，共享，核心设施的使用， 服务（如成像中心、麻醉设备等），3)促进共享独特的 和有价值的啮齿类动物品系，4）能够更有效地利用动物舍 通过减少隔离“干净”和“肮脏”动物所需的房间数量， 允许更有效地使用人员，从而通过简化交通来降低劳动力成本 模式和其他遏制措施。 项目PI是美国实验动物医学学院的文凭， 在设计和实施啮齿动物生物安全计划方面有广泛的培训和经验。 此外，本申请中列出的PI和其他专业人员具有兽医， 对受此影响的动物设施进行管理和运营监督 格兰特. UIUC每年投资超过1，500，000美元直接支持其实验室动物/生物医学 研究计划。这笔资金用于人员薪金、翻修/维护、设备 核心设施（如转基因小鼠和多克隆抗体）的支出和支持 生产单位）。每日赠款支出每年还产生1 380 000美元 来资助我们的实验动物护理和使用项目 该项目的范围不会对环境产生负面影响，也不需要 对现有动物设施的任何翻新或修改。职业健康安全 将解决问题，以确保安全和有效地使用消毒二氧化氯气体， 发生器.