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Exploratory Phase I/II Clinical Studies to Improve the Therapeutic Ratio of

探索性 I/II 期临床研究以提高治疗比率

基本信息

批准号：
8716844
负责人：
Helen A Shih
金额：
$ 21.58万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-04-01 至 2019-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8716844
关键词：
Acute Adverse effects Anaplastic Meningioma Anatomy Bathing Cancer Patient Cardiac Caring Charge Chest wall structure Child Clinical Clinical Research Clinical Treatment Clinical Trials Clinical effectiveness Dose Epiphysial cartilage Glioblastoma Goals Growth Height Instruction Intensity-Modulated Radiotherapy Internal Breast Prosthesis Lead Left Linear Energy Transfer Lung Lymphedema Malignant Neoplasms Mastectomy Maximum Tolerated Dose Methods Metric Mission Modality Normal tissue morphology Outcome Patients Phase Phase I Clinical Trials Phase II Clinical Trials Photons Pneumonia Positioning Attribute Protons Public Health Radiation Randomized Randomized Clinical Trials Research Retroperitoneal Sarcoma Retroperitoneal Space Scanning Site Skin Spinal Techniques Testing Therapeutic Toxic effect United States base biophysical tools clinical research site cohort high risk improved irradiation malignant breast neoplasm particle patient population programs proton therapy spine bone structure tool treatment planning tumor vertebra body

项目摘要

The goal of this project is to perform non-randomized clinical studies, seeking to improve the therapeutic ratio of protons by exploiting the potential clinical advantage(s) of the reduced dose bath using optimized intensity modulated protons (IMPT), in clinical sites that we hypothesize will result in reduced non-target radiation dose and normal tissue toxicity. We judge these sites are not yet ready for randomized studies. Optimizing proton RT with scanned beams, delineating and controlling target position, finely determining end-of-range, and robust intensity modulation can improve target dose conformity, maximizing local tumor control. We seek to optimize IMPT using investigational biophysical tools. We will also explore modulation of the LET distribution with scanned protons for radiobiologic advantage in a phase I clinical study in CNS malignancies. This project supports the mission of the NCI to improve the treatment and continuing care of cancer patients.

该项目的目标是进行非随机临床研究，寻求改善治疗效果。通过利用减少剂量浴的潜在临床优势，使用优化的强度调制质子（IMPT），我们假设将导致非靶向辐射剂量和正常组织毒性。我们判断这些研究中心尚未准备好进行随机研究。通过扫描光束优化质子RT，描绘和控制靶位置，精细确定范围末端和鲁棒的强度调制可以改善靶剂量一致性，最大化局部肿瘤控制我们寻求使用研究性生物物理工具优化IMPT。我们还将探讨调制在中枢神经系统I期临床研究中利用扫描质子进行LET分布的放射生物学优势恶性肿瘤该项目支持NCI的使命，以改善治疗和持续护理癌症患者。