Exploratory Phase I/II Clinical Studies to Improve the Therapeutic Ratio of

该项目的目标是进行非随机临床研究，寻求改善治疗 用优化的方法挖掘减剂量浴的潜在临床优势的质子比(S) 强度调制质子(IMPT)，在我们假设将导致非靶点减少的临床部位 辐射剂量和正常组织毒性。我们判断，这些网站还没有准备好进行随机研究。 用扫描束优化质子RT，勾画和控制靶位置，精细确定 射程结束，强大的强度调制可以改善靶区剂量一致性，最大限度地扩大局部肿瘤 控制力。我们寻求使用研究性生物物理工具来优化IMPT。我们还将探索调制 中枢神经系统I期临床研究中具有放射生物学优势的扫描质子的LET分布 恶性肿瘤。该项目支持NCI改善治疗和持续护理的使命 癌症患者。

The goal of this project is to perform non-randomized clinical studies, seeking to improve the therapeutic ratio of protons by exploiting the potential clinical advantage(s) of the reduced dose bath using optimized intensity modulated protons (IMPT), in clinical sites that we hypothesize will result in reduced non-target radiation dose and normal tissue toxicity. We judge these sites are not yet ready for randomized studies. Optimizing proton RT with scanned beams, delineating and controlling target position, finely determining end-of-range, and robust intensity modulation can improve target dose conformity, maximizing local tumor control. We seek to optimize IMPT using investigational biophysical tools. We will also explore modulation of the LET distribution with scanned protons for radiobiologic advantage in a phase I clinical study in CNS malignancies. This project supports the mission of the NCI to improve the treatment and continuing care of cancer patients.