Exploratory Phase I/II Clinical Studies to Improve the Therapeutic Ratio of

该项目的目标是进行非随机临床研究，寻求改善治疗效果。 通过利用减少剂量浴的潜在临床优势，使用优化的 强度调制质子（IMPT），我们假设将导致非靶向 辐射剂量和正常组织毒性。我们判断这些研究中心尚未准备好进行随机研究。 通过扫描光束优化质子RT，描绘和控制靶位置，精细确定 范围末端和鲁棒的强度调制可以改善靶剂量一致性，最大化局部肿瘤 控制我们寻求使用研究性生物物理工具优化IMPT。我们还将探讨调制 在中枢神经系统I期临床研究中利用扫描质子进行LET分布的放射生物学优势 恶性肿瘤该项目支持NCI的使命，以改善治疗和持续护理 癌症患者。

The goal of this project is to perform non-randomized clinical studies, seeking to improve the therapeutic ratio of protons by exploiting the potential clinical advantage(s) of the reduced dose bath using optimized intensity modulated protons (IMPT), in clinical sites that we hypothesize will result in reduced non-target radiation dose and normal tissue toxicity. We judge these sites are not yet ready for randomized studies. Optimizing proton RT with scanned beams, delineating and controlling target position, finely determining end-of-range, and robust intensity modulation can improve target dose conformity, maximizing local tumor control. We seek to optimize IMPT using investigational biophysical tools. We will also explore modulation of the LET distribution with scanned protons for radiobiologic advantage in a phase I clinical study in CNS malignancies. This project supports the mission of the NCI to improve the treatment and continuing care of cancer patients.