物化纳米表征核心-猫眼课题宝

物化纳米表征核心

批准号：

8710077

负责人：

SRINIVAS SRIDHAR

金额：

$8.02万

依托单位：

NORTHEASTERN UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

已结题

起止时间：

至 2015-10-31

来源：

https://reporter.nih.gov/project-details/8710077

关键词：

Adsorption Algorithms Antineoplastic Agents Area Atomic Force Microscopy Basic Science Biodistribution Blood Buffers CCNE1 gene Characteristics Charge Chemicals Databases Defense Mechanisms Dendrimers Drug Formulations Engineering Feedback Fluorescence Genes Laboratories Lipids Liposomes Malignant Neoplasms Measurement Micelles Microscopic Microscopy Mission Morphology Multi-Drug Resistance Nanotechnology Optics Pharmaceutical Preparations Plasma Production Property Reporting Research Personnel Resolution Role Sampling Scanning Electron Microscopy Scientist Small Interfering RNA Spectrum Analysis Staging Surface System Testing Translating Transmission Electron Microscopy Variant Work analytical tool base cancer cell cancer therapy chemical property design manufacturing scale-up nano nanocarrier nanomedicine nanoparticle nanosystems novel pre-clinical research clinical testing tumor ultraviolet

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英文摘要

PHYSICO-CHEIVIICAL NANOCHARACTERIZATION CORE . The role of this core will be to provide the necessary physico-chemical characterization of nanopreparations such as polymeric nanoparticles, lipid nanoparticles, dendrimers, and selfassembling nanosystems prepared in all the CCNE projects. An array of sophisticated microscopic, spectroscopic and analytical tools are available to study the size, size distribution, stability, surface charge, and drug loading/release from these nanopreparations. This core brings expertise in the basic science and engineering aspects of nanotechnology that is essential to understand the fundamental properties of these nanopreparations. Feedback from this core will help the scientists engaged in these projects to optimize these nanopreparations for successful use in cancer therapy. This core will also work in parallel with Nano Characterization Laboratory (NCL) to facilitate the overall mission of this CCNE to translate basic research to industrial production of nanomedicines.

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