IGF::OT::IGF MATERNAL FOLIC ACID SUPPLEMENTATION AND LEUKEMIA RISK IN CHILDREN: A POOLING OF PROSPECTIVE DATA IN THE INTERNATIONAL CHILDHOOD CANCER COHORT CONSORTIUM (I4C)

IGF::OT::IGF 母体叶酸补充剂与儿童白血病风险：国际儿童癌症队列联盟 (I4C) 前瞻性数据汇总

• 批准号: 8947540
• 负责人: VIREN ABEYASINGHE
• 金额: $ 4.5万
• 依托单位: MURDOCH CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-08 至 2015-04-07
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8947540
• 关键词: Acute Lymphocytic Leukemia; Affect; Child; Childhood Leukemia; Cohort Studies; Data; Data Analyses; Fasting; Folate; Folic Acid; Goals; Intake; International; Live Birth; Malignant Childhood Neoplasm; Malignant Neoplasms; Meta-Analysis; Mothers; Obesity; Pregnancy; Pregnant Women; Reporting; Resources; Risk; Sample Size; Serum; Supplementation; Testing; Toxic Environmental Substances; Vitamin B Complex; Woman; cohort; feeding; fortification; interest; leukemia; pregnant; prospective

There has been a deep interest in the environmental causes of childhood cancer but it is difficult to study because cancer in children is rare and because it is difficult to identify past exposure levels, particularly during important periods such as pregnancy. There is now a unique opportunity to prospectively study whether maternal folic acid supplementation affects leukemia risk in children. This data analysis project leverages on the resource of the International Childhood Cancer Cohort Consortium (I4C), a large consortium of several prospective mother-child cohorts. For this analysis, the plan is to pool data from five large prospective cohorts within the I4C. These five prospective cohorts have a combined sample size of 475,353 live births from 502,466 mothers. Approximately 200 cases of childhood leukemia and 550 cases of all cancers combined have been identified as of September 2011. Data is available on maternal folic acid supplementation as well as data to assess confounding. The goal of the proposed analysis is to test the hypothesis that folic acid supplementation in pregnant mothers reduces the risk of leukemia (acute lymphoblastic leukemia and other subtypes) in their children.

人们对儿童癌症的环境原因非常感兴趣，但很难研究，因为儿童癌症很罕见，而且很难确定过去的暴露水平，特别是在怀孕等重要时期。现在有一个独特的机会来前瞻性地研究母亲补充叶酸是否会影响儿童白血病的风险。该数据分析项目利用了国际儿童癌症队列联盟（I4C）的资源，这是一个由几个前瞻性母婴队列组成的大型联盟。对于本分析，计划汇总I4C中5个大型前瞻性队列的数据。这五个前瞻性队列的总样本量为502，466名母亲的475，353例活产婴儿。截至2011年9月，共发现约200例儿童白血病和550例所有癌症。有关于母亲补充叶酸的数据以及评估混杂因素的数据。拟议分析的目标是检验孕妇补充叶酸可以降低孩子患白血病（急性淋巴细胞白血病和其他亚型）风险的假设。