2014 Molecular Mechanisms in Lymphatic Function and Disease Gordon Research Confe

申请者描述(由申请人提供)：本申请是对将于2014年3月9日至14日在意大利文艺复兴托斯卡纳Il Ciocco度假村举行的第六届戈登淋巴功能和疾病分子机制研究会议的部分支持，以及与其相关的GRS于3月7日至9日在同一地点举行。该会议自2004年以来每两年举行一次，由戈登研究会议组织，该组织以其会议的高质量、尖端性质而闻名国际； 是关联GRS的第一年。这可以说是淋巴研究界最令人兴奋和最重要的会议。2014年庆祝其第10个年头的同时，人们越来越多地认识到淋巴管如何在越来越多的体内平衡和疾病过程中做出贡献，并帮助将淋巴生物学和生理学与从血管生成和肿瘤转移到脂肪生成和免疫等多个相关领域架起了桥梁。在过去的十年里，人们越来越认识到淋巴管不仅在其传统的液体、脂肪和细胞运输功能中发挥着重要作用，而且在一系列疾病的基本过程中也发挥着重要作用。例如，淋巴管生成与几乎所有的急性和慢性炎症过程有关，最近几年揭示了淋巴管内皮细胞及其引流功能在直接调节获得性免疫方面的全新作用。此外，淋巴管及其运输功能在调节脂质代谢方面的新作用正在出现，以及淋巴管在盐平衡和间质组织重塑中的新作用。因此，淋巴生物学家、癌症研究人员、生理学家、生物医学工程师和医生前所未有地需要聚集在一个论坛上，围绕这一领域的科学发展进行广泛的对话，并确定未来基础和临床研究工作的方向。新的淋巴领域在病理学、炎症、心血管和肿瘤生物学的广泛领域得到了应用，并为临床翻译做出了新的努力。本次会议将汇集淋巴生物学领域的顶尖基础和临床专家，以及免疫、新陈代谢和血管生物学相关领域的专家，他们是淋巴研究界的新成员，他们的贡献将引发新的对话和合作，帮助引入新的范式，并将该领域引向新的方向。

DESCRIPTION (provided by applicant): This application is for partial support of the sixth Gordon Research Conference on Molecular Mechanisms in Lymphatic Function and Disease to be held at the Renaissance Tuscany Il Ciocco Resort in Italy during the week of March 9-14, 2014, along with its associated GRS in the same location March 7-9. This conference has been held every two years since 2004 and is organized by the Gordon Research Conferences, an organization internationally known for the high quality, cutting- edge nature of its meetings; this is the first year for the associated GRS. This is arguably the most exciting and important meeting for the lymphatic research community. Celebrating its 10th year in 2014, its evolution has paralleled an ever- growing appreciation of how lymphatic vessels contribute to an increasing number of homeostatic and disease processes, and it has helped bridge lymphatic biology and physiology with a number of related fields from angiogenesis and tumor metastasis to adipogenesis and immunity. In the last decade, it is becoming increasingly appreciated that lymphatic vessels play important roles not only in their traditional functions of fluid, lipid and ell transport, but also in generic processes underlying a broad range of diseases. For example, lymphangiogenesis has been associated with nearly all acute and chronic inflammatory processes, and the last few years have brought to light completely new roles for both lymphatic endothelial cells and their drainage functions in directly modulating adaptive immunity. Additionally, new roles of lymphatic vessels and their transport functions in modulating lipid metabolism are emerging, as well as new roles for lymphatics in salt balance and stromal tissue remodeling. Therefore, there is an unprecedented need for lymphatic biologists, cancer researchers, physiologists, biomedical engineers and physicians to congregate in a forum and conduct a broad dialogue surrounding scientific developments in this field and to determine the direction of future basic and clinically- oriented investigative efforts. The new lymphatic field finds applications in broad areas of pathology, inflammation, cardiovascular and tumor biology with new efforts for clinical translation. This meeting will bring together the leading basic and clinically oriented experts in lymphatic biology with experts in related areas of immunity, metabolism, and vascular biology who are new to the lymphatic research community, whose contributions will spark new dialogue and collaborations, help usher in new paradigms, and guide the field in new directions.