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Translational Research in Pelvic Floor Disorders

盆底疾病的转化研究

基本信息

批准号：
8703627
负责人：
JENNIFER M. WU
金额：
$ 12.72万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-05-15 至 2016-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8703627
关键词：
Abdomen Accounting Address Affect Bladder Candidate Disease Gene Characteristics Chromosomes Clinical Clinical Research Collaborations Complex Computer Simulation Decision Making Disease Elastin Epidemiology Etiology Event Extracellular Matrix Family history of Female Fostering Foundations Functional disorder Future Gene Mutation General Population Genes Genetic Genetic Markers Genetic Polymorphism Genetic Predisposition to Disease Genetic Research Genetic screening method Goals Health Care Costs High Prevalence High Risk Woman Human Genetics Impairment Institution Intestines Investigation Knowledge Medical Mentored Patient-Oriented Research Career Development Award Mentors Mentorship Modeling Myosin ATPase Myosin Phosphatase Pathway Natural History Nature Operative Surgical Procedures Organ Patients Pelvic Floor Disorders Pelvic Pain Pelvis Penetrance Physicians Plant Roots Postmenopause Prevalence Prevention Prevention strategy Preventive Intervention Ptosis Public Health Quality of life Recommendation Recurrence Relative (related person)Research Risk Risk Factors Scientist Sensitivity and Specificity Siblings Single Nucleotide Polymorphism Surgical Management Susceptibility Gene Testing Training Translating Translational Research Uterus Vagina Vaginal Prolapses Vaginal delivery procedure Woman Women&apos s Health burden of illness career clinical practice clinical risk cost effective economic cost economic impact economic outcome end stage disease epidemiologic data experience genetic epidemiology genetic linkage analysis genetic pedigree genetic risk factor genetic variant health economics high risk improved innovation models and simulation multidisciplinary novel public health relevance skeletal skills tool translational medicine treatment strategy

项目摘要

DESCRIPTION (provided by applicant): My long-term career goal is to substantially improve women's health in the field of urogynecology by becoming a well-trained, independent clinician-scientist who is able to use innovative tools to identify the root causes of pelvic floor disorders and translate those findings into improved clinical practice. To achieve this goal, I have obtained the essential clinical and surgical training in urogynecology to fully comprehend the challenges in prevention, management and treatment of pelvic floor disorders. I have also developed a robust foundation in clinical research and modeling through my MPH in epidemiology and prior research endeavors. Through these collective experiences, I ultimately realized that advances in translational research, focused on the pathophysiology of pelvic floor disorders, are needed to revolutionize women's health in urogynecology. Thus, I am applying for this K23 Mentored Patient-Oriented Research Career Development Award in order to obtain advanced training and mentorship in human genetics and genetic epidemiology. Topic: Female pelvic floor disorders (PFD) represent a major public health burden given their high prevalence, impairment of quality of life, and substantial economic costs. The underlying pathophysiology of these disorders is not well understood, and without this critical knowledge, effective preventive strategies and long-term treatments have not been developed. Identification of the fundamental causes of PFDs will be achieved through innovative translational research. Plan: My multidisciplinary educational plan entails acquiring additional skills in genetic epidemiology through intensive coursework, dedicated mentoring and productive research. My research will focus on identifying genetic risk factors for pelvic organ prolapse through a candidate gene association study (Aim 1). Through this research, I will gain crucial "hands-on" experience and knowledge, strengthen collaborations within and across institutions, and establish the groundwork for future, large-scale investigations. With advances in our understanding of the genetic susceptibility for prolapse, it is critical to simultaneously explore how we will eventually integrate these genetic findings into clinical practice. Thus, I will also estimate the potential clinical and economic impact of a genetic susceptibility test for prolapse using a computer simulation model (Aim 2). This novel proposal will foster valuable collaboration between clinical scientists and geneticists and advance the implementation of translational medicine into the evolving field of urogynecology in order to ultimately improve women's health.

描述（由申请人提供）：我的长期职业目标是通过成为一名训练有素的独立临床医生科学家，能够使用创新工具来识别盆底疾病的根本原因，并将这些发现转化为改善的临床实践，从而大大改善女性在泌尿妇科领域的健康。为了实现这一目标，我已经获得了必要的临床和外科培训，在泌尿妇科充分理解预防，管理和治疗盆底疾病的挑战。我还通过我的流行病学硕士学位和先前的研究工作，在临床研究和建模方面打下了坚实的基础。通过这些集体的经验，我最终意识到，在转化研究的进展，重点是盆底疾病的病理生理学，需要彻底改变妇女的健康在泌尿妇科。因此，我申请这个K23指导以患者为导向的研究职业发展奖，以获得人类遗传学和遗传流行病学的高级培训和指导。题目：女性骨盆底疾病（PFD）是一个主要的公共卫生负担，因为它们的高患病率，损害生活质量，和巨大的经济成本。这些疾病的潜在病理生理学尚未得到很好的理解，如果没有这些关键知识，有效的预防策略和长期治疗尚未开发。将通过创新的转化研究来确定PFDs的根本原因。计划：我的多学科教育计划需要通过强化课程，专门的指导和富有成效的研究获得遗传流行病学的额外技能。我的研究将集中于通过候选基因关联研究（目的1）确定盆腔器官脱垂的遗传风险因素。通过这项研究，我将获得关键的“实践”经验和知识，加强机构内和机构间的合作，并为未来的大规模调查奠定基础。随着我们对脱垂遗传易感性的理解的进步，同时探索我们最终如何将这些遗传发现整合到临床实践中至关重要。因此，我也将估计潜在的临床和经济影响的遗传易感性测试脱垂使用计算机模拟模型（目标2）。这项新颖的提案将促进临床科学家和遗传学家之间的宝贵合作，并推动转化医学在不断发展的泌尿妇科领域的实施，以最终改善女性的健康。