A Hard and Clear, Estrogen-Free Replacement for Bisphenol-A Based Polycarbonates

一种坚硬、透明、不含雌激素的双酚 A 基聚碳酸酯替代品

• 批准号: 8723823
• 负责人: Yantian Wang
• 金额: $ 47.85万
• 依托单位: PLASTIPURE, INC.
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8723823
• 关键词: Acids; Adolescent; Adverse effects; Advertising; Aggressive behavior; Attention; Behavioral; Beverages; Biological Assay; Brain; Characteristics; Chemicals; Cognitive; Complex Mixtures; Data; Development; Disease; Dose; Drug Formulations; Emotions; Endocrine Disruptors; Estrogens; Exhibits; Exposure to; Family; Food; Food Packaging; Freezing; Functional disorder; Glycols; Grant; Health; Heat Stress Disorders; Human; Infant; Ingestion; Injection of therapeutic agent; Interagency Coordinating Committee on the Validation of Alternative Methods; Juice; Learning Disabilities; Legal patent; Link; MCF7 cell; Malignant Neoplasms; Mammals; Marketing; Measures; Mechanics; Methods; Molds; Motivation; Obesity; Oils; Ovarian; Oxygen; Paper; Pathology; Peer Review; Phase; Physiological Processes; Plant Resins; Plastics; Polyethylene Terephthalates; Polyethylenes; Polymers; Polypropylenes; Polystyrenes; Property; Puberty; Public Health; Publications; Publishing; Reporting; Resistance; Risk; Scientist; Sex Orientation; Small Business Innovation Research Grant; Sperm Count Procedure; Stress; Sunlight; Testing; Thick; Ultraviolet Rays; Water; base; bisphenol A; cancer type; chemical release; consumer product; estrogenic activity; fetal; flexibility; in vitro Assay; in vivo; meetings; microwave electromagnetic radiation; monomer; novel; oxidation; phthalates; physical process; polycarbonate; polycarbonate plastic; prevent; prostate enlargement; public health relevance; soft drink; xenoestrogen

DESCRIPTION (provided by applicant): Many peer-reviewed publications show that Bisphenol A (BPA)-based polycarbonate (PC) and all other commonly used hard and clear (HC) plastics (e.g., polyethylene terephthalate (PET), glycol-modified polyethylene terephthalate (PETG), and polystyrene (PS)) leach endocrine disrupting chemicals that most commonly exhibit estrogenic activity (EA). BPA is only one of many hundreds of chemicals having EA or anti- EA used to manufacture HC plastic products. Chemicals having EA or anti-EA have been reported to have significant adverse effects on many behavioral and physiological processes such as sperm counts, uterine and ovarian functions, aggressive behaviors, and some types of cancers. These adverse effects sometimes occur at very low (picomolar to nanomolar) concentrations, especially on fetal or developing mammals (including humans). PlastiPure's (PPi's) data show that no consumer products or packaging made from EA-free** HC plastic are currently commercially available, including those made from PC substitutes currently advertised as BPA-free or phthalate-free. In fact, BPA-free plastics often release chemicals having more EA than do plastics made using BPA (e.g., PC plastics), especially when exposed to sunlight or other UV wavelengths. In order to meet a commercial and health-related need for plastics free of EA and anti-EA (EA-free** plastics), PPi is submitting a Phase II SBIR grant to confirm that it has developed a set of EA-free** resins that directly substitute for PC, PET, PETG, and PS resins that have many advantageous characteristics in different combinations, e.g., HC, microwavable, resistant to UV light and moisture, acid resistant, cold-tolerant (including freezing), and suitable for making thick- or thin-layered plastics, some of which have an oxygen barrier. PPi proposes to confirm that plastic products manufactured from these EA-free** resins remain EA- free** before and after common-use stresses of heat, moisture, UV and microwave radiation. PPi will use two very sensitive, reproducible and accurate in vitro assays and an in vivo assay to confirm that no chemicals having detectable EA are released from these resins or plastic products before or after stressing. Collectively, the novel EA-free**, BPA-free, HC plastics to be developed on this Phase II grant would replace PET, PETG, and other HC beverage and food-contacting plastics in highest-volume current use that all release chemicals having EA**. Products produced from these resins represent the best commercial opportunity, and the greatest potential reduction in chemicals having EA** that are currently released from plastics and ingested by consumers world-wide.

描述（由申请人提供）：许多同行评审的出版物表明，基于双酚A （BPA）的聚碳酸酯（PC）和所有其他常用的硬透明（HC）塑料（例如，聚对苯二甲酸乙二醇酯（PET），乙二醇改性聚对苯二甲酸乙二醇酯（PETG）和聚苯乙烯（PS））浸出内分泌干扰化学物质，最常见的是表现出雌激素活性（EA）。BPA只是用于制造HC塑料制品的数百种具有EA或反EA的化学品之一。据报道，含有EA或抗EA的化学物质对许多行为和生理过程有显著的不利影响，如精子数量、子宫和卵巢功能、攻击行为和某些类型的癌症。这些不良反应有时发生在非常低的浓度（皮摩尔到纳摩尔），特别是对胎儿或发育中的哺乳动物（包括人类）。PlastiPure （PPi）的数据显示，目前市面上没有由不含ea ** HC塑料制成的消费品或包装，包括那些由目前宣传为不含双酚a或邻苯二甲酸酯的PC替代品制成的产品。事实上，不含双酚a的塑料通常比使用双酚a制成的塑料（例如PC塑料）释放出的化学物质具有更多的EA，特别是当暴露在阳光或其他紫外线波长下时。为了满足商业和健康相关对无EA和抗EA塑料（无EA塑料）的需求，PPi正在提交II期SBIR拨款，以确认其已开发出一套无EA树脂，可直接替代PC， PET， PETG和PS树脂，这些树脂在不同的组合中具有许多优势特性，例如HC，可微波，耐紫外线和潮湿，耐酸，耐寒（包括冷冻），并且适合制造厚层或薄层塑料，其中一些具有氧气屏障。PPi建议确认由这些不含EA树脂制造的塑料产品在高温、潮湿、紫外线和微波辐射的常用应力之前和之后都保持不含EA。PPi将使用两种非常敏感、可重复和准确的体外测定和体内测定，以确认在应力前后这些树脂或塑料制品中没有可检测到EA的化学物质释放。总的来说，在第二阶段拨款中开发的新型不含EA**、不含bpa **的HC塑料将取代目前使用量最大的PET、PETG和其他HC饮料和食品接触塑料，这些塑料都会释放含有EA**的化学物质。由这些树脂生产的产品代表着最佳的商业机会，也是最大可能减少目前从塑料中释放并被全球消费者摄入的含有EA**的化学物质的产品。