Investigating pathways to alleviate the burden of diabetes and kidney disease

研究减轻糖尿病和肾脏疾病负担的途径

• 批准号: nhmrc : GNT1102935
• 负责人: Prof Josephine Forbes
• 金额: $ 62.27万
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigating-pathways-alleviate-kidney-disease/1346245
• 关键词: Investigating; pathways; alleviate; burden; diabetes

Diabetes affects more than 1.2 million Australians and up to 40% of these will develop complications including kidney disease. Excess blood sugar as the result of diabetes can accelerate a biochemical process called advanced glycation, which permanently alters proteins affecting their structure and function. My research will focus on identifying new therapies to target advanced glycation as well as dysfunction of cell power stations, mitochondria which is caused by advanced glycation.

糖尿病影响着120多万澳大利亚人，其中高达40%的人会出现包括肾脏疾病在内的并发症。糖尿病导致的血糖过高会加速一种称为晚期糖化的生化过程，这种过程会永久改变影响其结构和功能的蛋白质。我的研究将集中在确定新的治疗方法，以针对晚期糖基化以及细胞发电站功能障碍，线粒体是由晚期糖基化引起的。