Steroid-catecholamine-brain interactions in auditory-driven social behavior

听觉驱动的社会行为中类固醇-儿茶酚胺-大脑的相互作用

• 批准号: 8661735
• 负责人: PAUL M. FORLANO
• 金额: $ 15.7万
• 依托单位: BROOKLYN COLLEGE
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-06-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8661735
• 关键词: Acute; Adrenergic Receptor; Animals; Area; Asperger Syndrome; Attention; Auditory; Auditory Physiology; Auditory system; Autistic Disorder; Bass; Behavior; Behavioral; Biological Models; Brain; Brain Diseases; Brain Stem; Catecholamines; Cell Nucleus; Cells; Chronic; Collaborations; Cues; Data; Disease; Dopamine; Dopamine Receptor; Dopaminergic Cell; Ear; Enzymes; Estrogen Replacements; Estrogens; Exhibits; Exposure to; Female; Fishes; Foundations; Funding; Future; Human; Hypothalamic structure; Incentives; Labyrinth; Long-Term Effects; Mammals; Measures; Midbrain structure; Modeling; Neurons; Norepinephrine; Patient currently pregnant; Peripheral; Phenotype; Population; Preoptic Areas; Process; Prosencephalon; Regulation; Research; Rewards; Role; Sensory; Sensory Process; Signal Pathway; Signal Transduction; Social Behavior; Social Functioning; Social Interaction; Source; Steroid Receptors; Steroids; Stimulus; Substantia nigra structure; System; Testing; Tyrosine 3-Monooxygenase; United States National Institutes of Health; Ventral Tegmental Area; Vertebrates; Work; auditory nuclei; auditory pathway; auditory stimulus; basal forebrain; behavior influence; hormone regulation; innovation; insight; locus ceruleus structure; male; mesolimbic system; nerve supply; neurochemistry; noradrenergic; pars compacta; receptor; research study; response; reward circuitry; social; sound; steroid hormone; vocalization

DESCRIPTION (provided by applicant): Catecholamine systems, which include dopamine and noradrenaline, are fundamental to the processes of social incentive and reward, but relevant studies have focused almost exclusively on the mesolimbic dopamine system, which influences behavioral responses to highly processed representations of environmental stimuli However, catecholamine projections are also observed to sensory areas of the brainstem and even to the auditory periphery, suggesting that social incentive processes may begin with the modulation of responsiveness in the auditory periphery and primary sensory areas of the brain. Most studies that have investigated steroid regulation of tyrosine hydroxylase (TH), the rate limiting enzyme in catecholamine synthesis, have focused on long term effects of estrogen replacement on the mesocorticolimbic dopaminergic system, but not in primary sensory processing areas. The objective of this proposal is to discover how steroid hormones interact with catecholamines in circuits important for normal auditory-driven social behavioral interactions. By employing a simple but powerful vertebrate model system in a robust behavioral experiment that involves an unambiguous response to a social auditory stimulus, the activation of specific brain nuclei with homologous neurochemical contents and connections to mammals and humans will be analyzed. Furthermore, by experimental manipulation of circulating steroid hormones, a better understanding will be gained of how steroids, such as estrogen, regulate catecholamines within peripheral, primary and secondary auditory processing centers. The contribution of the proposed research is expected to provide a greater understanding of the involvement of catecholaminergic neurons during behavioral response to social auditory signals, and the mechanisms of chronic and acute steroid regulation of catecholamines in the central and peripheral auditory system. This contribution will be significant because it will become the foundation for future research that will provide insight to the role of catecholamines and their regulation by steroids in brain circuits required for normal social function. The proposed project is innovative, in our opinion, because it employs a simple vertebrate model system and has the advantage of measuring an unambiguous behavioral response to an important social auditory stimulus that is not tenable in mammalian models.

描述（申请人提供）：包括多巴胺和去甲肾上腺素在内的儿茶酚胺系统是社会激励和奖励过程的基础，但相关研究几乎完全集中在中脑边缘多巴胺系统上，该系统影响对环境刺激的高度加工表征的行为反应。然而，还观察到脑干的感觉区域甚至听觉周边的儿茶酚胺投射，这表明社会激励过程可能开始于大脑听觉外围和初级感觉区域的反应性调节。大多数研究已经调查了类固醇调节酪氨酸羟化酶（TH），在儿茶酚胺合成的限速酶，都集中在雌激素替代对mesocorticolimbic多巴胺能系统的长期影响，但不是在初级感觉加工区。这个建议的目的是发现类固醇激素如何与儿茶酚胺相互作用的电路重要的正常神经驱动的社会行为的相互作用。通过采用一个简单但功能强大的脊椎动物模型系统，在一个强大的行为实验，涉及一个明确的反应，社会听觉刺激，激活特定的脑核同源神经化学物质的内容和连接到哺乳动物和人类将被分析。此外，通过循环类固醇激素的实验操作，将获得更好的了解类固醇，如雌激素，调节外周，初级和次级听觉处理中心内的儿茶酚胺。该研究的贡献有望为更好地了解社会听觉信号行为反应过程中儿茶酚胺能神经元的参与，以及中枢和外周听觉系统中儿茶酚胺的慢性和急性类固醇调节机制提供帮助。这一贡献将是重要的，因为它将成为未来研究的基础，这将提供对儿茶酚胺的作用及其在正常社会功能所需的脑回路中的类固醇调节的见解。在我们看来，所提出的项目是创新的，因为它采用了一个简单的脊椎动物模型系统，并具有测量一个明确的行为反应的一个重要的社会听觉刺激，是站不住脚的哺乳动物模型的优势。

项目成果

Catecholaminergic innervation of central and peripheral auditory circuitry varies with reproductive state in female midshipman fish, Porichthys notatus.

• DOI: 10.1371/journal.pone.0121914
• 发表时间: 2015
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Forlano PM;Ghahramani ZN;Monestime CM;Kurochkin P;Chernenko A;Milkis D
• 通讯作者: Milkis D

Catecholaminergic Fiber Innervation of the Vocal Motor System Is Intrasexually Dimorphic in a Teleost with Alternative Reproductive Tactics.

• DOI: 10.1159/000438720
• 发表时间: 2015
• 期刊: Brain, behavior and evolution
• 作者: Ghahramani ZN;Timothy M;Kaur G;Gorbonosov M;Chernenko A;Forlano PM
• 通讯作者: Forlano PM

Testosterone Treatment Mimics Seasonal Downregulation of Dopamine Innervation in the Auditory System of Female Midshipman Fish

睾酮治疗模拟雌性见习鱼听觉系统多巴胺神经支配的季节性下调

• DOI: 10.1093/icb/icab070
• 发表时间: 2021
• 期刊: Integrative and Comparative Biology
• 影响因子: 2.6
• 作者: Perelmuter, Jonathan T;Hom, Kelsey N;Mohr, Robert A;Demis, Lina;Kim, Spencer;Chernenko, Alena;Timothy, Miky;Middleton, Mollie A;Sisneros, Joseph A;Forlano, Paul M
• 通讯作者: Forlano, Paul M