Catecholaminergic innervation of central and peripheral auditory circuitry varies with reproductive state in female midshipman fish, Porichthys notatus.
Catecholaminergic innervation of central and peripheral auditory circuitry varies with reproductive state in female midshipman fish, Porichthys notatus.
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DOI：
10.1371/journal.pone.0121914
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Milkis D
中科院分区：
文献类型：
--
作者：
Forlano PM;Ghahramani ZN;Monestime CM;Kurochkin P;Chernenko A;Milkis D
在季节性繁殖的脊椎动物中，儿茶酚胺的激素调节，包括多巴胺和去甲肾上腺素，可能在一定程度上调节对同种发声的行为反应。然而，听觉核团中儿茶酚胺神经支配的自然季节变化在很大程度上尚未被探索，特别是在启动社会声刺激编码的外周听觉系统中。已被证明是探索季节性外周听觉可塑性与生殖社会行为相关的机制的一个极好的模型。最近，我们展示了强大的儿茶酚胺(CA)神经支配遍及整个听觉系统的学员。最值得注意的是，间脑中的多巴胺能神经元广泛地投射到听觉回路，包括直接支配听力的主要内脏神经球囊，以及也投射到内耳的胆碱能八头肌传出核(OE)。在这里，我们测试了这样的假设：与非生殖的冬季雌性相比，怀孕、生殖的夏季雌性在听觉系统中表现出不同的CA神经支配。我们使用定量免疫荧光技术来测量中央听觉核团和球囊感觉上皮的酪氨酸羟化酶免疫反应(TH-IR)纤维密度。生殖雌性在两个前脑区域，包括听觉丘脑，TH-IR神经分布密度较高，在OE的体细胞和树突上TH-IR分布密度较高。相反，非生殖雌性在球囊中有更多的TH-IR终末，在听觉后脑的某个区域有更多的TH-IR纤维密度，在视前区有更多的TH-IR神经元。这些数据提供了证据，证明儿茶酚胺可能在一定程度上发挥作用，以季节性地调节内耳的敏感性，进而调节对生殖声音信号的适当行为反应。
In seasonal breeding vertebrates, hormone regulation of catecholamines, which include dopamine and noradrenaline, may function, in part, to modulate behavioral responses to conspecific vocalizations. However, natural seasonal changes in catecholamine innervation of auditory nuclei is largely unexplored, especially in the peripheral auditory system, where encoding of social acoustic stimuli is initiated. The plainfin midshipman fish, Porichthys notatus, has proven to be an excellent model to explore mechanisms underlying seasonal peripheral auditory plasticity related to reproductive social behavior. Recently, we demonstrated robust catecholaminergic (CA) innervation throughout the auditory system in midshipman. Most notably, dopaminergic neurons in the diencephalon have widespread projections to auditory circuitry including direct innervation of the saccule, the main endorgan of hearing, and the cholinergic octavolateralis efferent nucleus (OE) which also projects to the inner ear. Here, we tested the hypothesis that gravid, reproductive summer females show differential CA innervation of the auditory system compared to non-reproductive winter females. We utilized quantitative immunofluorescence to measure tyrosine hydroxylase immunoreactive (TH-ir) fiber density throughout central auditory nuclei and the sensory epithelium of the saccule. Reproductive females exhibited greater density of TH-ir innervation in two forebrain areas including the auditory thalamus and greater density of TH-ir on somata and dendrites of the OE. In contrast, non-reproductive females had greater numbers of TH-ir terminals in the saccule and greater TH-ir fiber density in a region of the auditory hindbrain as well as greater numbers of TH-ir neurons in the preoptic area. These data provide evidence that catecholamines may function, in part, to seasonally modulate the sensitivity of the inner ear and, in turn, the appropriate behavioral response to reproductive acoustic signals.
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影响因子：
2.5
作者：
Filippi, Alida;Mueller, Thomas;Driever, Wolfgang
通讯作者：
Driever, Wolfgang
DOI：
10.1016/s0960-0760(01)00147-9
发表时间：
2001-12-01
影响因子：
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作者：
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作者：
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影响因子：
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作者：
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