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Prevention of PTSD III: Neurocognitive Training of Emotional Regulation

预防PTSD III：情绪调节的神经认知训练

基本信息

批准号：
8701651
负责人：
Arieh Y Shalev
金额：
$ 34.46万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-04-17 至 2016-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8701651
关键词：
Accident and Emergency department Address Adherence Affect Amygdaloid structure Anterior Anxiety Anxiety Disorders Attention Back Base of the Brain Caring Chronic Chronic Disease Chronic Post Traumatic Stress Disorder Clinical Cognitive Computers Conflict (Psychology)Derivation procedure Disease Dissociation Distal Dose Educational Intervention Emotional Emotions Enrollment Event Exposure to Foundations Functional disorder General Hospitals Goals Heart Rate Hostility Hydrocortisone Impairment Insula of Reil Internet Intervention Intervention Studies Label Lateral Learning Life Stress Major Depressive Disorder Measures Mental Depression Mood Disorders Moods National Institute of Mental Health Neurocognitive Neuronal Plasticity Neurotic Disorders Online Systems Outcome Outcome Measure Participant Patients Performance Phase Plant Roots Post-Traumatic Stress Disorders Prefrontal Cortex Prevention Process Psychological Transfer Psychopathology Quality of life Randomized Randomized Clinical Trials Randomized Controlled Clinical Trials Randomized Controlled Trials Reaction Reaction Time Recovery Recruitment Activity Regulation Research Domain Criteria Resistance Resolution Risk Self Efficacy Shapes Short-Term Memory Sleep Stimulus Strategic Planning Survivors Symptoms System Task Performances Testing Time Training Trauma Treatment Efficacy University Hospitals Video Games Work base clinical effect clinical efficacy coping distraction dosage early experience efficacy trial emotion regulation executive function improved innovation neurobehavioral neurocognitive test novel prevent primary outcome public health relevance response secondary outcome success

项目摘要

DESCRIPTION (provided by applicant): The proposed work will evaluate the ability of neurocognitive retraining of executive functions and emotional regulation to reduce neurocognitive dysfunctions that follow trauma exposure and thereby prevent PTSD. The scientific rationale for this work is the hypothesis that impaired emotional regulation interferes with the expected recovery from the early responses to traumatic events, leading into a chronic disorder. In an initial phase we will recruit 20 recently traumatized participants among trauma survivors admitted to a general hospital emergency room and test the planned intervention's acceptance and right 'dosing'. In the second phase we will enroll 80 recent survivors into a randomized controlled study of the new intervention. The intervention will consist of web-based neurobehavioral training interventions that instill an emotional bias toward positive stimuli, improve emotion recognition and labeling, reduce resistance to emotional distraction, and enhance executive functioning. Control participants will complete web-based video games that do not have emotion-regulatory benefits. Outcome measures will include improvement in neurocognitive functioning and in PTSD symptoms.

描述（由申请人提供）：拟议的工作将评估执行功能和情绪调节的神经认知再训练的能力，以减少创伤暴露后的神经认知功能障碍，从而预防 PTSD。这项工作的科学原理是假设情绪调节受损会干扰对创伤事件的早期反应的预期恢复，从而导致慢性疾病。在初始阶段，我们将在综合医院急诊室的创伤幸存者中招募 20 名最近遭受创伤的参与者，并测试计划的干预措施的接受度和正确的“剂量”。在第二阶段，我们将招募 80 名新近幸存者参加新干预措施的随机对照研究。该干预措施将包括基于网络的神经行为训练干预措施，灌输对积极刺激的情绪偏见，改善情绪识别和标签，减少对情绪分心的抵抗，并增强执行功能。控制参与者将完成没有情绪调节益处的基于网络的视频游戏。结果测量将包括神经认知功能和创伤后应激障碍症状的改善。