Clinical Samples

在这个题为“系统”的项目中，对免疫接种后产生的免疫应答进行了拟议的分析， 健康和低反应人群的疫苗反应分析”，将利用收集 各种样品类型的技术。事实上，这个项目的累积努力将产生一个 这是一套非常宝贵的样本，可作为拟议研究和未来实验问题的资源。 因此，临床样本核心的必要和重要的使命是确保所有样本， 每个项目产生的临床信息将被系统地编目和跟踪， 适当储存和适当传播。临床样本核心将利用 完善的基础设施和BIIR研究人员与其他研究人员之间的成功合作 参与网站 通过将来自U19的所有样本的接收、处理和分发整合到一个统一的结构中， 临床样本核心将为各种分析和免疫分析提供高质量的临床样本。 在中心的所有项目中提出的研究。拟议的基础设施将优化使用 不同研究者之间的样本和资源，提供必要的协同作用和整合， 一种高效和具有成本效益的方式。总之，临床样本核心将使我们能够进行研究 我们认为，通过实现以下目标，对实现中心的总体目标至关重要 主要目标：1）保证进样的完整性; 2）保证质量和一致性 3）对所有样本实施共同的样本ID命名法， 收集网站，这反过来又将促进项目内和项目间的数据集成和分析; 4）工作 与BIIR更广泛的数据管理计划，这将有助于确保在此 该项目将在未来的项目中重新分析。

The proposed analysis of immune responses generated after immunization in this project entitled, "Systems Analysis of Vaccine Responses in Healthy and Hyporesponsive Humans", will take advantage of a collection of technologies on a variety of sample types. Indeed, the cumulative efforts from this project will generate an invaluable set of samples as a resource both for the proposed studies and future experimental questions. Thus, the necessary and important mission of the Clinical Sample Core is to insure that all specimens, clinical information that is generated by each of the projects will be systematically catalogued and tracked, adequately stored, and appropriately disseminated. The Clinical Sample Core will take advantage of the well-established infrastructure and successful collaboration between the investigators at BIIR and other participating sites. By consolidating the receipt, handling, and distribution of all samples from this U19 into one unified structure, the Clinical Sample Core will provide high quality clinical samples for the various analyses and immune studies proposed across all of the projects in the Center. The proposed infrastructure will optimize the use of samples and resources among the different investigators, providing the necessary synergy and integration in an efficient and cost-effective manner. Summarily, the Clinical Sample Core will allow us to carry out studies that we consider essential for achieving the overall goals of the Center by accomplishing the following significant objectives: 1) guarantee the integrity of incoming samples; 2) ensure the quality and consistency of the clinical data associated with the samples; 3) enforce a common sample ID nomenclature for all collection sites it which in turn will facilitate data integration and analysis within and across projects; 4) work with the broader data management scheme at BIIR that will help assure that the data generated in this project will be available for re-analysis in future projects.