Clinical Samples

对免疫后产生的免疫反应的拟议分析载于题为“系统”的项目 对健康和低反应性人类的疫苗反应的分析》，将利用收集的 关于各种样本类型的技术。事实上，这个项目的累积努力将产生一个 一组宝贵的样本，作为拟议研究和未来实验问题的资源。 因此，临床样本核心的必要和重要的任务是确保所有样本， 由每个项目产生的临床信息将被系统地编目和跟踪， 充分储存，并适当传播。临床样本核心将利用 BIIR和其他机构的调查人员之间建立了良好的基础设施和成功的合作 参与站点。 通过将来自该U19的所有样品的接收、处理和分发合并到一个统一的结构中， 临床样本核心将为各种分析和免疫提供高质量的临床样本 该中心所有项目都提出了研究建议。拟议的基础设施将优化使用 不同调查人员之间的样本和资源，提供必要的协同和整合 高效率和高成本效益的方式。总而言之，临床样本核心将允许我们进行研究 我们认为，要实现中心的总体目标，必须做到以下几点 重要目标：1)保证进货样品的完整性；2)确保质量和一致性 与样本相关的临床数据；3)对所有人执行共同的样本ID命名法 信息技术收集站点，进而促进项目内部和跨项目的数据集成和分析；4)工作 使用BIIR更广泛的数据管理方案，将有助于确保在此 该项目将在未来的项目中进行重新分析。

The proposed analysis of immune responses generated after immunization in this project entitled, "Systems Analysis of Vaccine Responses in Healthy and Hyporesponsive Humans", will take advantage of a collection of technologies on a variety of sample types. Indeed, the cumulative efforts from this project will generate an invaluable set of samples as a resource both for the proposed studies and future experimental questions. Thus, the necessary and important mission of the Clinical Sample Core is to insure that all specimens, clinical information that is generated by each of the projects will be systematically catalogued and tracked, adequately stored, and appropriately disseminated. The Clinical Sample Core will take advantage of the well-established infrastructure and successful collaboration between the investigators at BIIR and other participating sites. By consolidating the receipt, handling, and distribution of all samples from this U19 into one unified structure, the Clinical Sample Core will provide high quality clinical samples for the various analyses and immune studies proposed across all of the projects in the Center. The proposed infrastructure will optimize the use of samples and resources among the different investigators, providing the necessary synergy and integration in an efficient and cost-effective manner. Summarily, the Clinical Sample Core will allow us to carry out studies that we consider essential for achieving the overall goals of the Center by accomplishing the following significant objectives: 1) guarantee the integrity of incoming samples; 2) ensure the quality and consistency of the clinical data associated with the samples; 3) enforce a common sample ID nomenclature for all collection sites it which in turn will facilitate data integration and analysis within and across projects; 4) work with the broader data management scheme at BIIR that will help assure that the data generated in this project will be available for re-analysis in future projects.