Conditioning Patients to Increase DC-vaccine Potency
对患者进行调理以提高 DC 疫苗的效力
基本信息
- 批准号:7122673
- 负责人:
- 金额:$ 10.09万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-03-01 至 2009-05-31
- 项目状态:已结题
- 来源:
- 关键词:CD34 moleculeantineoplasticsbiotechnologycellular immunityclinical trial phase Iclinical trial phase IIcombination cancer therapycyclophosphamidecytotoxic T lymphocytedendritic cellshelper T lymphocytehematopoietic stem cellshuman subjecthuman therapy evaluationimmune responseimmunomodulatorsimmunosuppressivemelanomaneoplasm /cancer chemotherapyneoplasm /cancer immunologyneoplasm /cancer immunotherapyneoplasm /cancer vaccinepatient oriented researchtumor antigensvaccine developmentvaccine evaluation
项目摘要
Vaccination of HLA-A*201 patients with metastatic melanoma with dendritic cells (DCs) derived from CD34+
hematopoietic cell progenitor cells (CD34+HPCs) loaded with melanoma peptide antigens, KLH and flu
peptide resulted in the induction of CD8+ T cell immunity to melanoma peptides and some clinical benefit.
Immunity was measured by the production of interferon-gamma in the presence of melanoma peptides and
control antigens by CD8+ T cells obtained from blood. T cell immunity correlated with early clinical outcome
and survival. Patients who progressed early had either no T cell immunity or transient T cell immunity to DC
vaccination. There may be several reasons for the absence of DC-induced CD8+ T cell immunity in these
patients including: the inability of DCs to prime T cells against tumor antigens, the presence of tumor
specific tolerance induced by host suppressor lymphocytes, and an insufficient anti-melanoma T cell
repertoire. AIM 1 will determine whether pre-treatment of patients with stage IV melanoma with CPA
improves the immune and clinical response after DC vaccination. We will carry out a phase l/ll randomized
clinical trial in patients with stage IV melanoma who will receive either placebo or CPA (500mg/m2) followed
by vaccination with CD34-DCs pulsed with melanoma peptides and KLH. As a control, a separate aliquot of
DCs will be pulsed with HIV peptides as neoantigens that will be mixed with the peptide-loaded DCs and
administered at the same time. The primary outcome is the induction of melanoma-specific CD8+T cell
immunity. The secondary outcome is the rate of objective clinical responses. Tertiary outcomes are:
reduction of regulatory/suppressor CD4+T cells (AIM 2) and priming of HIV-specific CD8+T cells (AIM 3).
CD34+来源树突状细胞(dc)转移性黑色素瘤患者的HLA-A*201疫苗接种
项目成果
期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JOSEPH Wayne FAY其他文献
JOSEPH Wayne FAY的其他文献
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{{ truncateString('JOSEPH Wayne FAY', 18)}}的其他基金
Conditioning Patients to Increase DC-vaccine Potency
对患者进行调理以提高 DC 疫苗的效力
- 批准号:
7631317 - 财政年份:2000
- 资助金额:
$ 10.09万 - 项目类别:
Conditioning Patients to Increase DC-vaccine Potency
对患者进行调理以提高 DC 疫苗的效力
- 批准号:
7460927 - 财政年份:
- 资助金额:
$ 10.09万 - 项目类别:
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