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Regulation of rodent energy metabolism, body weight and composition

Regulation of rodent energy metabolism, body weight and composition
啮齿动物能量代谢、体重和成分的调节
批准号：
8939492
负责人：
KEVIN HALL
金额：
$6.82万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8939492
关键词：
BehaviorBody CompositionBody WeightBody Weight decreasedBrainCorpus striatum structureDataDevelopmentDiabetes MellitusDietDopamineEatingEnergy MetabolismFood EnergyInvestigationMolecularMusObesityOrganismPhysical activityRegulationRodentRoleSignal TransductionWeight Gainenergy balanceimprovedinterestmathematical modelmouse model

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英文摘要
We created a mathematical model of mouse energy metabolism that provides a quantitative framework for investigating energy balance relationships in mouse models of obesity and diabetes. We are now investigating body weight regulation of mice subjected to various ad libitum diets inducing weight gain and loss. We are particularly interested in the role of striatal dopamine signaling in food intake and physical activity behavior and we are studying how weight gain and loss on various diets leads to changes in brain dopamine signaling.
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Interactions of diet, exercise, metabolism, and weight change in humans
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Regulation of rodent energy metabolism, body weight and composition
Interactions of diet, exercise, metabolism, and weight change in humans
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