Disrupted development of neural connections by alcohol initiation in adolescence

青春期酒精引发的神经连接发育受到破坏

基本信息

  • 批准号:
    8693876
  • 负责人:
  • 金额:
    $ 52.64万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-09-20 至 2016-06-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): This application is a resubmitted R01 proposal in response to PA-09-097 Alcohol, Decision- Making, and Adolescent Brain Development (NIAAA). The project capitalizes upon an existing longitudinal sample of adolescents who were enrolled starting in 2004 in a longitudinal brain development study. Participants, ages 9 to 23, underwent an extensive structural neuroimaging protocol that included T1-weighted and diffusion-weighted scans, and also completed a comprehensive behavioral testing battery and a set of self- report questionnaires. Most participants were free of alcohol and drug use at study enrollment. Participants completed one follow-up assessment, two years after the baseline enrollment, using similar data collection methods as at baseline. [A third assessment wave was completed on approximately half the sample since this proposal was reviewed]. Here, funds are requested to conduct two additional longitudinal assessments of the full sample (n=170), many of whom have transitioned from no alcohol use to significant use over time. To date, found age-related improvements were found in numerous frontal lobe-mediated functions, including planning, delay discounting, inhibitory control, and motivated decision making. These functions are associated with white matter integrity throughout the brain, but particularly within tracts that connect the frontal lobe with striatal brain regions. Preliminary findings indicate that individuals who initiated alcohol use, and/or increased their use over time, showed signs of reduced white matter development, specifically with respect to fiber pathways that provide connectivity among cortical regions (superior parietal, anterior temporal, prefrontal) involved in high-level associative processes as well as inhibitory cognitive and behavioral control. Additionally, longitudinal effects of alcohol use include reduced volume of neural fibers connecting the key subcortical structure involved in mediating incentive-reward activation, the nucleus accumbens, with the key cortical region involved in providing descending inhibitory control over behavioral responses to reward cues, the medial orbitofrontal cortex. [Preliminary findings from the partial Time 3 data collection include reductions in white matter integrity of brain regions directly involved in memory processes (hippocampal gyrus, temporal polar cortex) in association with escalating alcohol use from Time 2 to Time 3.] Additional longitudinal assessment will permit a more sophisticated modeling, using linear mixed models, of the effects of adolescent alcohol initiation on ongoing neural connectivity development, together with parallel analyses on associations between behavioral and brain development and how alcohol initiation impacts them. Within the proposed study, the investigators will be able to assess brain connectivity via structural MRI, electrophysiology, resting state fMRI, and a broad range of behavioral tasks. Thus, this application meets NIAAA funding objectives, because the scientific inquiry into the question of alcohol's effects on the developing brain will be advanced.
描述(由申请人提供):本申请是针对 PA-09-097 酒精、决策和青少年大脑发育 (NIAAA) 重新提交的 R01 提案。该项目利用了从 2004 年开始参加纵向大脑发育研究的现有青少年纵向样本。年龄在 9 至 23 岁之间的参与者接受了广泛的结构神经影像检查,其中包括 T1 加权和弥散加权扫描,并完成了全面的行为测试和一套自我报告问卷。大多数参与者在研究登记时没有饮酒和吸毒。参与者在基线入组两年后使用与基线类似的数据收集方法完成了一项后续评估。 [自审查该提案以来,已对大约一半的样本完成了第三次评估]。在此,需要资金对整个样本(n = 170)进行两次额外的纵向评估,其中许多人随着时间的推移已经从不饮酒转变为大量饮酒。迄今为止,我们发现许多额叶介导的功能都出现了与年龄相关的改善,包括计划、延迟贴现、抑制控制和动机性决策。这些功能与整个大脑的白质完整性有关,特别是在连接额叶和纹状体大脑区域的脑束内。初步研究结果表明,开始饮酒和/或随着时间的推移增加饮酒的个体表现出白质发育减少的迹象,特别是在参与高级联想过程以及抑制性认知和行为控制的皮质区域(顶上叶、前颞叶、前额叶)之间提供连接的纤维通路方面。此外,饮酒的纵向影响包括神经纤维体积减少,该神经纤维连接参与介导激励-奖励激活的关键皮质下结构(伏隔核)和关键皮质区域,该区域参与对奖励线索的行为反应提供下行抑制控制,即内侧眶额皮质。 [部分时间 3 数据收集的初步发现包括直接参与记忆过程的大脑区域(海马回、颞极皮层)的白质完整性降低,与从时间 2 到时间 3 的饮酒量不断增加有关。]额外的纵向评估将允许使用线性混合模型对青少年饮酒对持续神经连接发展的影响进行更复杂的建模,并进行并行分析 行为和大脑发育之间的关联以及酒精开始如何影响它们。在拟议的研究中,研究人员将能够通过结构 MRI、电生理学、静息态 fMRI 和广泛的行为任务来评估大脑连接性。因此,该申请符合 NIAAA 的资助目标,因为将推进对酒精对发育中大脑的影响问题的科学探究。

项目成果

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Monica Luciana其他文献

Monica Luciana的其他文献

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{{ truncateString('Monica Luciana', 18)}}的其他基金

Training in genetic and neurobehavioral mechanisms of addiction
成瘾遗传和神经行为机制的培训
  • 批准号:
    10625300
  • 财政年份:
    2020
  • 资助金额:
    $ 52.64万
  • 项目类别:
Training in genetic and neurobehavioral mechanisms of addiction
成瘾遗传和神经行为机制的培训
  • 批准号:
    10166819
  • 财政年份:
    2020
  • 资助金额:
    $ 52.64万
  • 项目类别:
Training in genetic and neurobehavioral mechanisms of addiction
成瘾遗传和神经行为机制的培训
  • 批准号:
    10400071
  • 财政年份:
    2020
  • 资助金额:
    $ 52.64万
  • 项目类别:
3/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT U MINNESOTA
3/21 ABCD-美国联盟:明尼苏达大学研究项目现场
  • 批准号:
    10596073
  • 财政年份:
    2015
  • 资助金额:
    $ 52.64万
  • 项目类别:
Disrupted development of neural connections by alcohol initiation in adolescence
青春期酒精引发的神经连接发育受到破坏
  • 批准号:
    8183655
  • 财政年份:
    2011
  • 资助金额:
    $ 52.64万
  • 项目类别:
Disrupted development of neural connections by alcohol initiation in adolescence
青春期酒精引发的神经连接发育受到破坏
  • 批准号:
    8887091
  • 财政年份:
    2011
  • 资助金额:
    $ 52.64万
  • 项目类别:
Disrupted development of neural connections by alcohol initiation in adolescence
青春期酒精引发的神经连接发育受到破坏
  • 批准号:
    8499167
  • 财政年份:
    2011
  • 资助金额:
    $ 52.64万
  • 项目类别:
Disrupted development of neural connections by alcohol initiation in adolescence
青春期酒精引发的神经连接发育受到破坏
  • 批准号:
    8334673
  • 财政年份:
    2011
  • 资助金额:
    $ 52.64万
  • 项目类别:
FUNCTIONAL NEUROIMAGING OF REWARD AND TIMING PROCESSES IN ADOLESCENTS
青少年奖励和计时过程的功能神经成像
  • 批准号:
    8362829
  • 财政年份:
    2011
  • 资助金额:
    $ 52.64万
  • 项目类别:
FUNCTIONAL NEUROIMAGING OF REWARD AND TIMING PROCESSES IN ADOLESCENTS
青少年奖励和计时过程的功能神经成像
  • 批准号:
    8170434
  • 财政年份:
    2010
  • 资助金额:
    $ 52.64万
  • 项目类别:

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