Adminsitrative Core

我们Cobre申请的目标是建立一个多学科中心，该中心将 加强阿尔弗雷德·I·杜邦儿童医院(AIDHC)和 特拉华州立大学(DSU)在特定领域对血红蛋白病的研究形成了 特拉华州综合镰刀细胞研究中心。这个由两个机构组成的中心将 增强来自几个互补学科的个人调查人员联合努力的能力 在镰状细胞病中，涉及的领域包括II珠蛋白基因的基因编辑和鉴定 利用下一代测序预测中风的遗传因素，试图解构角色 研究SCD相关疼痛中的炎症，以确定儿童SCD的心理社会风险。这个 行政核心将展示3名目标调查员和2名具有试点研究的调查员 有专门为他们的个人需求量身定做的研究、指导和教育计划。 已经确立了监督他们成为成功的独立调查员的基准。 我们通向自给自足的规划道路已经阐明，包括将采取的步骤，以实现 批判性学术质量。最后，执行委员会、指导单位、 内部和外部咨询委员会及其个人监督责任和作用如下 描述，包括PD/PI。

The objective of our COBRE application is the establishment of a multidisciplinary Center which will strengthen the biomedical research infrastructures of the Alfred I. duPont Hospital for Children (AIDHC) and Delaware State University (DSU) in the specific area of Hemoglobinopathy research by the formation of the Delaware Comprehensive Sickle Cell Research Center. This Center encompassing both Institutions will enhance the ability of individual investigators from several complementary disciplines to combine their efforts in Sickle Cell Disease covering a territory ranging from gene editing of the Ii Globin gene and identifying genetic predictors of stroke using next generation sequencing, to an attempt at the deconstruction of the role of inflammation in SCD-related pain, to the identification of psychosocial risk in pediatric SCD. The Administrative Core will demonstrate that the 3 Target Investigators and the 2 Investigators with Pilot studies have had research, mentoring and educational programs specifically tailored to meet their individual needs. Benchmarks to monitor their progression into successful independent investigators have been established. Our programmatic path to self-sufficiency is articulated, including the steps that will be undertaken to attain a critical academic mass. Finally the role and composition of the Executive Committee, Mentoring Units, Internal and External Advisory Committees and their individual oversight responsibilities and roles are described, including that of the PD/PI.