Adminsitrative Core

行政核心

• 批准号: 8662851
• 负责人: MARIE J. STUART
• 金额: $ 39.26万
• 依托单位: ALFRED I. DU PONT HOSP FOR CHILDREN
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8662851
• 关键词: Advisory Committees; Africa South of the Sahara; African American; Amino Acid Substitution; Annual Reports; Area; Basic Science; Benchmarking; Biomedical Research; Caring; Centers of Research Excellence; Chemistry; Childhood; Chronic; Clinical Medicine; Clinical Research; Defect; Delaware; Discipline; Disease; Erythrocytes; Functional disorder; Funding; Future; Genes; Genetic; Globin; Grant; Grenada; Guidelines; Hematological Disease; Hemoglobin; Hemoglobinopathies; Individual; Infant; Inflammation; Institution; Institutional Review Boards; Leadership; Link; Longevity; Maintenance; Medical Students; Mentors; Mentorship; Minority; Mission; Monitor; Organ; Pain; Pediatric Hospitals; Peer Review; Physicians; Pilot Projects; Population; Process; Research; Research Infrastructure; Research Personnel; Resources; Risk; Role; Running; Schedule; Sickle Cell; Sickle Cell Anemia; Site; Stroke; Students; Suggestion; Training; Translational Research; United States National Institutes of Health; Universities; Work; Writing; base; career; meetings; member; multidisciplinary; next generation sequencing; operation; programs; psychosocial; recessive genetic trait; sickling; skills; success; translational medicine; web site

The objective of our COBRE application is the establishment of a multidisciplinary Center which will strengthen the biomedical research infrastructures of the Alfred I. duPont Hospital for Children (AIDHC) and Delaware State University (DSU) in the specific area of Hemoglobinopathy research by the formation of the Delaware Comprehensive Sickle Cell Research Center. This Center encompassing both Institutions will enhance the ability of individual investigators from several complementary disciplines to combine their efforts in Sickle Cell Disease covering a territory ranging from gene editing of the Ii Globin gene and identifying genetic predictors of stroke using next generation sequencing, to an attempt at the deconstruction of the role of inflammation in SCD-related pain, to the identification of psychosocial risk in pediatric SCD. The Administrative Core will demonstrate that the 3 Target Investigators and the 2 Investigators with Pilot studies have had research, mentoring and educational programs specifically tailored to meet their individual needs. Benchmarks to monitor their progression into successful independent investigators have been established. Our programmatic path to self-sufficiency is articulated, including the steps that will be undertaken to attain a critical academic mass. Finally the role and composition of the Executive Committee, Mentoring Units, Internal and External Advisory Committees and their individual oversight responsibilities and roles are described, including that of the PD/PI.

我们 COBRE 应用程序的目标是建立一个多学科中心，该中心将 加强阿尔弗雷德·杜邦儿童医院 (AIDHC) 的生物医学研究基础设施，以及 特拉华州立大学 (DSU) 在血红蛋白病研究的特定领域建立了 特拉华州综合镰状细胞研究中心。该中心涵盖两个机构，将 增强来自多个互补学科的个体研究者联合努力的能力 镰状细胞病的研究涵盖了从 Ii 球蛋白基因的基因编辑到识别的领域 使用下一代测序来预测中风的遗传因素，试图解构这一角色 SCD 相关疼痛中的炎症，以识别儿科 SCD 的心理社会风险。这 行政核心将证明 3 名目标研究人员和 2 名试点研究研究人员 有专门为满足他们的个人需求而定制的研究、指导和教育计划。 已经建立了监测他们成为成功的独立研究者的基准。 我们阐明了实现自给自足的计划路径，包括为实现自给自足而采取的步骤 临界学术质量。最后是执行委员会、指导单位的作用和组成， 内部和外部咨询委员会及其个人监督职责和作用 描述，包括 PD/PI 的描述。