Investigating the Role of Exosomal Shuttle RNA in Mediating Pathogenesis of Neurodegenerative Disorders

研究外泌体穿梭 RNA 在介导神经退行性疾病发病机制中的作用

• 批准号: nhmrc : 567046
• 负责人: Dr Shayne Bellingham
• 金额: $ 19.51万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigating-role-exosomal-neurodegenerative-disorders/116032
• 关键词: Investigating; Role; Exosomal; Shuttle; RNA

The risk for dementia increases with age and is placing a growing burden upon Australian medical resources. Novel genetic signals can be communicated between cells. This process may contribute to the development of dementia related disorders, such as Alzheimer's and Prion diseases. We hope to identify the genetic signals communicated between cells that may contribute to dementia. This will help us develop novel treatments that delay the onset or ultimately prevent Alzheimer's and Prion disease.

老年痴呆症的风险随着年龄的增长而增加，这给澳大利亚的医疗资源带来了越来越大的负担。新的遗传信号可以在细胞之间传递。这一过程可能导致痴呆相关疾病的发展，如阿尔茨海默病和朊病毒病。我们希望能够识别出可能导致痴呆症的细胞之间传递的遗传信号。这将帮助我们开发新的治疗方法，延迟或最终预防阿尔茨海默病和朊病毒病。