Identification and Characterisation of Genes involved in the Copper Regulation of the Human Alzheimer's Disease Amyloid-Beta Precursor Protein (APP) Gene

参与人类阿尔茨海默氏病淀粉样β前体蛋白 (APP) 基因铜调节的基因的鉴定和表征

• 批准号: DI0560757
• 负责人: Dr Shayne Bellingham
• 金额: $ 11.45万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Indigenous Researchers Development
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-07-04 至 2007-07-03
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DI0560757
• 关键词: Identification; Characterisation; Genes; involved; Copper

Alzheimer's disease (AD) is the most common form of dementia in the ageing population. This research project aims to identify and characterise new genes involved in the copper regulation of the Alzheimer's disease gene. This may lead to the development of novel therapeutic targets and clinical intervention strategies as well as early diagnostic procedures in preventative healthcare for the treatment of AD. The benefits would affect the international community as a whole, potentially minimising the socio-economic costs arising from the predicted world-wide increase in AD in the ageing population.

阿尔茨海默病（AD）是老年人群中最常见的痴呆症。该研究项目旨在识别和表征与阿尔茨海默病基因铜调控有关的新基因。这可能会导致新的治疗靶点和临床干预策略的发展，以及早期诊断程序的预防性保健治疗阿尔茨海默病。这些好处将影响整个国际社会，有可能最大限度地减少因预计全球老年人口中老年痴呆症增加而造成的社会经济成本。