Text Message Physical Activity Intervention to Treat Cognitive Deficits in HIV

短信体育活动干预治疗艾滋病毒认知缺陷

• 批准号: 8743277
• 负责人: Brook Henry
• 金额: $ 19.38万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-26 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8743277
• 关键词: AIDS neuropathy; Acquired Immunodeficiency Syndrome; Activities of Daily Living; Address; Adherence; Adverse effects; Aging; Alzheimer' s Disease; Arts; Behavior; Behavior Therapy; Body Weight decreased; California; Car Phone; Cardiopulmonary; Caring; Cognition; Cognitive; Cognitive deficits; Communication; Control Groups; Dementia; Development; Devices; Diabetes Mellitus; Diet; Disease; Electronic Mail; Electronics; Environment; Exhibits; Family; Feedback; Focus Groups; Functional disorder; Funding; Goals; HIV; HIV Infections; HIV Seropositivity; HIV risk; Health; Health Promotion; Health behavior; Image; Impaired cognition; Impairment; Incidence; Individual; Information Technology; Institutes; Intervention; Intervention Studies; Label; Life; Link; Measures; Mental disorders; Methodology; Methods; Modification; Monitor; Morbidity - disease rate; Multimedia; Neurocognitive; Neurocognitive Deficit; Neuropathy; Participant; Patient Self-Report; Performance; Persons; Pharmaceutical Preparations; Physical activity; Population; Prevalence; Protocols documentation; Public Health; Quality of life; Randomized; Randomized Controlled Trials; Reporting; Research; Research Personnel; Resources; Running; Services; Structure; Symptoms; System; Technology; Telecommunications; Text; Time; Travel; United States National Institutes of Health; Viral; Weight Gain; Wireless Technology; Work; antiretroviral therapy; base; cognitive function; cohort; design; fitness; group intervention; improved; mHealth; medication compliance; mortality; multidisciplinary; neurobehavioral; neuropsychological; novel; programs; public health relevance; service intervention; smoking cessation; social; success; theories; web site; willingness

DESCRIPTION (provided by applicant): HIV infection is frequently characterized by neurocognitive deficits collectively labeled as HIV-associated neurocognitive disorders (HAND). While the use of combination antiretroviral therapies (CART) have dramatically reduced AIDS-related morbidity, HAND remains a significant public health concern linked to impaired everyday functioning and poor quality of life in HIV-positive (HIV+) individuals. Despite the continued prevalence of HAND in the CART era, there are no empirically validated strategies to effectively treat neurocognitive dysfunction in this population. Physical activity (PA) has been utilized as an effective non- pharmacological method to improve cognitive performance in individuals with dementia and psychiatric disorders. PA interventions in HIV+ subjects are reported to improve cardiopulmonary fitness, but the effects of PA on HAND have not been well characterized. Previous HIV PA interventions also involve rigorous PA (running on a treadmill) and significant participant resources (traveling to a gym multiple times per week) that may not be suitable or practical for many HIV+ individuals. We propose to conduct a randomized controlled trial to administer a personalized interactive mobile phone text messaging intervention to increase moderate PA and improve cognitive function in HIV+ participants with HAND. This study will utilize a Short Message Service/Multimedia Message Service (SMS/MMS) platform developed by the California Institute for Telecommunications and Information Technology (Calit2), which conducts state-of-art health promotions using mobile electronic devices. 50 HIV+ participants will be randomly assigned to a control group or a 4-month intervention group that will receive daily SMS/MMS mobile phone messages designed to increase PA. The intervention condition, based on control theory, is structured to promote goal-setting by using SMS text prompts and MMS images to monitor PA, provide goal reminders, promote goal strategies, and deliver feedback on goal progress. We will conduct focus groups to identify HIV-specific PA limitations (e.g., medication side effects, neuropathy) and identify ways to overcome these barriers. Text messages will be tailored to each individual, including their social contacts and environment. We hypothesize that HIV+ participants administered this intervention will exhibit a significant increase in PA compared to a control group as assessed by pedometer step counts, accelerometer activity, and self-reported PA on the 7-Day Physical Activity Recall (PAR). Further, we propose that the intervention will improve cognitive performance and everyday functioning compared to the control condition as quantified by a comprehensive neuropsychological battery and self-report and performance-based measures of daily living activities. Findings from this proposal will lay the groundwork for development of novel large-scale personalized mobile PA interventions dedicated to treating HAND and improving the quality of life for HIV+ individuals.

描述（由申请人提供）：HIV感染经常以神经认知缺陷为特征，该缺陷统称为HIV相关的神经认知疾病（Hand）。虽然使用抗逆转录病毒疗法（CART）大大降低了与AIDS相关的发病率，但HAND仍然是与HIV阳性（HIV+）患者日常功能受损和生活质量差有关的重要公共卫生问题。尽管手推车时代的手持续持续流行，但没有经验验证的策略可以有效治疗该人群中神经认知功能障碍。体育活动（PA）已被用作 有效的非药理方法可以改善痴呆症和精神疾病患者的认知性能。据报道，PA对HIV+受试者的干预措施可改善心肺健康状况，但手头上PA的影响并未得到很好的特征。以前的HIV PA干预措施还涉及严格的PA（在跑步机上运行）和大量的参与者资源（每周多次前往健身房），这可能不适合许多HIV+个人。我们建议进行一项随机对照试验，以管理个性化的交互式手机文本消息干预措施，以增加中等PA并提高艾滋病毒+参与者的认知功能。这项研究将利用由加利福尼亚电信和信息技术研究所开发的简短消息服务/多媒体消息服务（SMS/MMS）平台，该平台（CALIT2）使用移动电子设备进行了最先进的健康促进。 50名HIV+参与者将被随机分配到对照组或一个为期4个月的干预组中，该小组将接收旨在增加PA的每日SMS/MMS手机消息。基于控制理论的干预条件旨在通过使用SMS文本提示和MMS图像来监视PA，提供目标提醒，促进目标策略并提供目标进度的反馈来促进目标设定。我们将进行焦点小组，以识别特异性PA的限制（例如，药物副作用，神经病），并确定克服这些障碍的方法。短信将针对每个人量身定制，包括他们的社交联系和环境。我们假设接受此干预措施的HIV+参与者将在7天的体育活动回忆中（PAR）评估，与对照组相比，与对照组相比，PA将显示出PA的显着增加。此外，我们建议，与通过全面的神经心理电池，自我报告以及基于绩效的日常生活活动的衡量标准相比，干预措施将改善认知表现和日常功能。该提案的发现将为开发新颖的大规模个性化移动PA干预措施开发奠定基础，该干预措施致力于治疗艾滋病毒+个人的生活质量。