Text Message Physical Activity Intervention to Treat Cognitive Deficits in HIV

短信体育活动干预治疗艾滋病毒认知缺陷

• 批准号: 8743277
• 负责人: Brook Henry
• 金额: $ 19.38万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-26 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8743277
• 关键词: AIDS neuropathy; Acquired Immunodeficiency Syndrome; Activities of Daily Living; Address; Adherence; Adverse effects; Aging; Alzheimer' s Disease; Arts; Behavior; Behavior Therapy; Body Weight decreased; California; Car Phone; Cardiopulmonary; Caring; Cognition; Cognitive; Cognitive deficits; Communication; Control Groups; Dementia; Development; Devices; Diabetes Mellitus; Diet; Disease; Electronic Mail; Electronics; Environment; Exhibits; Family; Feedback; Focus Groups; Functional disorder; Funding; Goals; HIV; HIV Infections; HIV Seropositivity; HIV risk; Health; Health Promotion; Health behavior; Image; Impaired cognition; Impairment; Incidence; Individual; Information Technology; Institutes; Intervention; Intervention Studies; Label; Life; Link; Measures; Mental disorders; Methodology; Methods; Modification; Monitor; Morbidity - disease rate; Multimedia; Neurocognitive; Neurocognitive Deficit; Neuropathy; Participant; Patient Self-Report; Performance; Persons; Pharmaceutical Preparations; Physical activity; Population; Prevalence; Protocols documentation; Public Health; Quality of life; Randomized; Randomized Controlled Trials; Reporting; Research; Research Personnel; Resources; Running; Services; Structure; Symptoms; System; Technology; Telecommunications; Text; Time; Travel; United States National Institutes of Health; Viral; Weight Gain; Wireless Technology; Work; antiretroviral therapy; base; cognitive function; cohort; design; fitness; group intervention; improved; mHealth; medication compliance; mortality; multidisciplinary; neurobehavioral; neuropsychological; novel; programs; public health relevance; service intervention; smoking cessation; social; success; theories; web site; willingness

DESCRIPTION (provided by applicant): HIV infection is frequently characterized by neurocognitive deficits collectively labeled as HIV-associated neurocognitive disorders (HAND). While the use of combination antiretroviral therapies (CART) have dramatically reduced AIDS-related morbidity, HAND remains a significant public health concern linked to impaired everyday functioning and poor quality of life in HIV-positive (HIV+) individuals. Despite the continued prevalence of HAND in the CART era, there are no empirically validated strategies to effectively treat neurocognitive dysfunction in this population. Physical activity (PA) has been utilized as an effective non- pharmacological method to improve cognitive performance in individuals with dementia and psychiatric disorders. PA interventions in HIV+ subjects are reported to improve cardiopulmonary fitness, but the effects of PA on HAND have not been well characterized. Previous HIV PA interventions also involve rigorous PA (running on a treadmill) and significant participant resources (traveling to a gym multiple times per week) that may not be suitable or practical for many HIV+ individuals. We propose to conduct a randomized controlled trial to administer a personalized interactive mobile phone text messaging intervention to increase moderate PA and improve cognitive function in HIV+ participants with HAND. This study will utilize a Short Message Service/Multimedia Message Service (SMS/MMS) platform developed by the California Institute for Telecommunications and Information Technology (Calit2), which conducts state-of-art health promotions using mobile electronic devices. 50 HIV+ participants will be randomly assigned to a control group or a 4-month intervention group that will receive daily SMS/MMS mobile phone messages designed to increase PA. The intervention condition, based on control theory, is structured to promote goal-setting by using SMS text prompts and MMS images to monitor PA, provide goal reminders, promote goal strategies, and deliver feedback on goal progress. We will conduct focus groups to identify HIV-specific PA limitations (e.g., medication side effects, neuropathy) and identify ways to overcome these barriers. Text messages will be tailored to each individual, including their social contacts and environment. We hypothesize that HIV+ participants administered this intervention will exhibit a significant increase in PA compared to a control group as assessed by pedometer step counts, accelerometer activity, and self-reported PA on the 7-Day Physical Activity Recall (PAR). Further, we propose that the intervention will improve cognitive performance and everyday functioning compared to the control condition as quantified by a comprehensive neuropsychological battery and self-report and performance-based measures of daily living activities. Findings from this proposal will lay the groundwork for development of novel large-scale personalized mobile PA interventions dedicated to treating HAND and improving the quality of life for HIV+ individuals.

描述（由申请人提供）：HIV感染通常以神经认知缺陷为特征，统称为HIV相关神经认知障碍（HAND）。虽然抗逆转录病毒联合疗法（CART）的使用大大降低了艾滋病相关的发病率，但HAND仍然是一个重大的公共卫生问题，与艾滋病毒阳性（HIV+）个体的日常功能受损和生活质量低下有关。尽管在CART时代HAND持续流行，但在这一人群中没有经验验证的有效治疗神经认知功能障碍的策略。体育活动（PA）已被用作一种