Unraveling Genetic Determinants of Lung Cancer Risk in African Americans

揭示非裔美国人肺癌风险的遗传决定因素

• 批准号: 8692685
• 负责人: Melinda Aldrich
• 金额: $ 16.01万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8692685
• 关键词: Admixture; African; African American; Architecture; Area; Award; Bioinformatics; Cancer Biology; Cancer Etiology; Cancer Patient; Caucasians; Caucasoid Race; Code; Cohort Studies; Collaborations; Communities; Complement; Complex; Computer Simulation; Data; Detection; Disease; Ensure; Environment; Environmental Risk Factor; Epidemiology; Ethnic group; European; Family; Funding; Genes; Genetic; Genetic Determinism; Genetic Predisposition to Disease; Genomics; Genotype; Goals; Health; Heritability; Incidence; Individual; Interdisciplinary Study; Investigation; K-Series Research Career Programs; Knowledge; Low income; Lung; Malignant Neoplasms; Malignant neoplasm of lung; Maps; Mentors; Mentorship; Metabolism; Methodology; Methods; Nature; Nicotine; Population; Population Heterogeneity; Postdoctoral Fellow; Predisposition; Primary Prevention; Relative (related person); Research; Research Personnel; Risk; Risk Factors; Scanning; Secondary Prevention; Smoking; Socioeconomic Factors; Tobacco smoking; Training; Translating; United States; Variant; Writing; base; cancer epidemiology; cancer genetics; cancer genome; cancer risk; career; case control; cohort; epidemiologic data; exome sequencing; experience; gene environment interaction; genetic epidemiology; genetic risk factor; genetic variant; genome wide association study; genome-wide analysis; health disparity; high risk; meetings; mortality; novel; programs; prospective; racial and ethnic; racial difference; rare variant; skills; smoking prevalence; socioeconomics

DESCRIPTION (provided by applicant): This Career Development Award will provide Dr. Aldrich with the didactic training and mentorship needed to further her career in genetics and bioinformatics as they relate to lung cancer in diverse populations. While Dr. Aldrich has had comprehensive training in epidemiologic methodology, statistical analysis, and scientific writing during her doctoral and post-doctoral experiences, she requires further training in her chosen research area, the genetic epidemiology of cancer. The proposed project focuses on genetic epidemiology of lung cancer risk in African Americans. This project will serve as a training opportunity so that Dr. Aldrich can expand her methodological focus and obtain the requisite training in genetics and bioinformatics to ultimately enhance the detection of genes associated with cancer in racially diverse populations. New knowledge and skills in lung cancer biology, health disparities, genetic epidemiology methods, and bioinformatics will be obtained in the training portion of the award through coursework, seminars, national meetings and mentorship. She will be mentored by leading experts in the fields of genetic epidemiology (Dr. Scott M. Williams), lung cancer biology (Dr. Pierre Massion), and cancer epidemiology (Dr. William J. Blot). Genetic factors influencing lung cancer susceptibility have not yet been thoroughly investigated, especially among African Americans, the population with the highest incidence of lung cancer. The research goal of this proposal is to use genetic ancestry to identify genetic variants and gene-environment interactions that contribute to lung cancer in African Americans. To identify factors contributing to lung cancer in African Americans, the research aims of this proposal are: 1) to perform admixture mapping; 2) to discover rare variants in exonic regions; and 3) to identify interactions between local ancestry and environmental risk factors. An ongoing prospective cohort, the Southern Community Cohort Study, as well as the national African American Lung Cancer Consortium, will be utilized in the proposed research. Ultimately this research will assist with the identification of high-risk subjects for primary and secondary prevention of lung cancer. With the knowledge and experience provided by this career development award, Dr. Aldrich will be prepared to seek R01 funding necessary to establish a multidisciplinary research program in lung cancer epidemiology. The experience gained from this career development award will ensure Dr. Aldrich's successful transition into an independent investigator in cancer epidemiology with a focus on genetic and environmental determinants of cancer in racially diverse populations.

描述（由申请人提供）：该职业发展奖将为Aldrich博士提供与各种人群中与肺癌有关的遗传学和生物信息学领域所需的教学培训和指导。尽管Aldrich博士在博士学位和博士后经历期间接受了流行病学方法论，统计分析和科学写作方面的全面培训，但她需要在所选的研究领域进行进一步的培训，即癌症的遗传流行病学。拟议的项目着重于非裔美国人肺癌风险的遗传流行病学。该项目将成为培训机会，以便Aldrich博士可以扩大其方法论的重点，并获得对遗传学和生物信息学的必要培训，以最终增强对种族多样性种群中与癌症相关的基因的检测。肺癌生物学，健康差异，遗传流行病学方法和生物信息学的新知识和技能将通过课程，研讨会，国家会议和指导在奖项的培训部分中获得。她将受到遗传流行病学领域（Scott M. Williams博士），肺癌生物学（Pierre Massion博士）和癌症流行病学（William J. Blot博士）的指导。影响肺癌敏感性的遗传因素尚未得到彻底研究，尤其是在非裔美国人中，肺癌发病率最高的人群。该提案的研究目的是利用遗传血统来识别有助于非裔美国人肺癌的遗传变异和基因环境相互作用。为了确定导致非裔美国人肺癌的因素，该提案的研究目的是：1）进行混合映射； 2）在外显子区域发现稀有变体； 3）确定地方血统与环境风险因素之间的相互作用。拟议的研究将使用一项持续的前瞻性队列，南方社区队列研究以及全国非裔美国人肺癌财团。最终，这项研究将有助于鉴定高风险受试者，以预防肺癌。凭借该职业发展奖提供的知识和经验，Aldrich博士将准备寻求R01资金，以建立肺癌流行病学的多学科研究计划。从这一职业发展奖中获得的经验将确保Aldrich博士成功地过渡到癌症流行病学独立研究者，重点是种族多样化人群中癌症的遗传和环境决定因素。