Investigating the role of mitochondrial Tom40 in regulated cell death and neurodegeneration.

研究线粒体 Tom40 在调节细胞死亡和神经变性中的作用。

• 批准号: nhmrc : 2004767
• 金额: $ 97.27万
• 依托单位国家: 澳大利亚
• 项目类别: Ideas Grants
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigating-role-mitochondrial-death-neurodegeneration/1780407
• 关键词: Investigating; role; mitochondrial; Tom40; regulated

Mitochondria are internal compartments of cells, separated by bounding membranes. They are crucial to the life and death of cells, and to quality of human life and ageing. Diseases of the nervous system can be caused when mitochondria do not function properly. Our aim is to discover why a protein complex called TOM embedded in the bounding membrane is linked to dementia in some people. This will also lead to a better general understanding of the connection between mitochondria and human health.

线粒体是细胞的内部隔室，由边界膜隔开。它们对细胞的生与死以及人类生活质量和衰老至关重要。当线粒体不能正常工作时，可以引起神经系统疾病。我们的目标是发现为什么一种名为TOM的蛋白质复合物嵌入在边界膜中与某些人的痴呆症有关。这也将有助于更好地了解线粒体与人类健康之间的联系。