Low Magnitude Mechanical Stimulation to Increase Muscle Strength in Frail Adults

低强度机械刺激可增强体弱成人的肌肉力量

• 批准号: 8461127
• 负责人: Thuy-Tien Le Dam
• 金额: $ 16.08万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8461127
• 关键词: Address; Adipose tissue; Adult; Affect; Aging; Area; Assisted Living Facilities; Atrophic; Biological Markers; Body Composition; Body fat; Cessation of life; Clinical; Clinical Research; Clinical Trials; Clinical Trials Design; Collaborations; Commit; Communities; Complement; Controlled Clinical Trials; Data; Development; Devices; Double-Blind Method; Elderly; Epidemiology; Event; Exercise; Fatty acid glycerol esters; Feasibility Studies; Figs - dietary; Fracture; Frail Elderly; Frail Older Adults; Funding; Gait; Gender; Geriatrics; Goals; Housing; Image; Infiltration; Institutes; Intervention; Isometric Exercise; Joints; K-Series Research Career Programs; Knee; Laboratories; Lead; Learning; Longitudinal Studies; Lower Extremity; Magnetic Resonance Imaging; Measures; Mechanical Stimulation; Mechanics; Mediator of activation protein; Mentors; Mentorship; Methodology; Muscle; Muscle Fibers; Muscle Weakness; Muscle function; Outcome; Performance; Peripheral; Physiology; Prevention; Public Health; Randomized; Recruitment Activity; Research Design; Research Personnel; Resources; Risk; Serious Adverse Event; Skeletal Muscle; Speed; Syndrome; Torque; Training; United States National Institutes of Health; Universities; Woman; Work; X-Ray Computed Tomography; adverse outcome; age related; aged; cohort; combat; disability; economic impact; experience; falls; frailty; grasp; high risk; human old age (65+); improved; men; mortality; multidisciplinary; muscle form; muscle strength; novel; open label; osteoporosis with pathological fracture; patient oriented; population based; prevent; programs; prospective; sarcopenia; skills; social; strength training; treatment duration; treatment strategy; vibration

DESCRIPTION (provided by applicant): Sarcopenia, the age-related loss of skeletal muscle mass, contributes to impaired mobility, frailty and disability. However, there is a mismatch between the loss in muscle mass and loss in muscle strength, suggesting that muscle quality is impaired with aging. Infiltration of fat into skeletal muscle (myosteatosis) affects muscle quality and may be related to impaired mobility and disability. Muscle quantity and muscle quality are potentially early modifiable factors in the development of frailty. The goal of this proposal is to examine whether infiltration of fat into skeletal muscle, assessed by peripheral quantitative computed tomography, independently and interactively predicts decline in muscle strength, physical performance, frailty, disability and death in a prospective cohort of 1,172 community dwelling men aged 65 years and older. Furthermore, we hypothesize that interventions that improve both muscle mass and quality will prevent weakness and disability. Thus, our second aim is to study whether a low-impact, nonpharmacologic device providing low magnitude mechanical stimulation to the whole body improves muscle strength in low functioning adults. This proposal will also explore whether low magnitude mechanical increases muscle mass and decrease intermuscular fat. Subjects will be recruited from local assisted living communities, which provide congregate housing and social events for many older adults. We hypothesize that low magnitude mechanical stimulation will help combat sarcopenia and loss of independence among frail older adults who are at the highest risk of adverse outcomes. The candidate for this mentored Patient-Oriented Career Development Award aims to complement her previous training in geriatrics and epidemiology with additional expertise in muscle physiology, body composition imaging methodology, and interventional clinical research. Columbia University has committed abundant resource to support this proposal including the use of bionutrition, biomarkers laboratory in the NIH CTSA-funded Irving Institute. A multidisciplinary mentorship team comprised of experts in frailty, body composition, intermuscular fat and clinical trial design in the elderly supports the proposal. The proposed studies should provide novel information about the importance of intermuscular fat in the development of disability, and could lead to new strategies for the treatment and prevention of sarcopenia.

描述（由申请人提供）：骨骼肌减少症，与年龄相关的骨骼肌质量损失，导致行动能力受损，虚弱和残疾。然而，肌肉质量的损失和肌肉力量的损失之间存在不匹配，这表明肌肉质量随着年龄的增长而受损。脂肪渗入骨骼肌（肌骨化病）影响肌肉质量