Administrative Core

项目概述（见说明）：行政核心为本项目的三个项目和另外两个核心项目提供行政服务。该计划项目提案汇集了几个小组的独特才能，对p66shc缺乏症延长寿命的机制进行综合和跨学科的分析，跨越多个生物组织水平，并利用多种不同类型的分析，以多种格式生成数据。行政核心是项目和核心之间协同互动的核心，事实上，自提案最初提交以来，行政核心已经证明了这些团体之间的研究交易的便利性。由于这种协同作用，该程序为She功能产生了多个新的假设。在过去的4年半的时间里，通过这种协调，项目项目进行的研究表明，Shcs控制肥胖、代谢、胰岛素信号传导和抗逆性，行政核心促进了我们实验室bbbb64篇论文的发表。该核心的具体目标是：1)提供一个组织结构，以加快和协调研究，促进研究人员之间的互动；2)监测和定期审查研究质量，并编写进度报告；3)管理项目财务部分；4)促进出版物、演讲和研究成果的传播；5)组织项目成员年会和外部评审委员会；6)协调和监控数据和资源共享。为了实现这些目标，核心A将组织和管理每月的电话会议、每周的实验室会议、每年的外部咨询委员会会议，以及用于七个单元之间数据交换的基于网络的服务器。

PROJECT SUMMARY (See instructions): The Administrative Core provides administrative services to the three projects and two other cores of this program project. The program project proposal brings together the unique talents of several groups to perform an integrative and interdisciplinary analysis of the mechanism by which p66Shc-deficiency extends lifespan, across several levels of biological organization, and utilizing analyses of many different types that generate data in multiple formats. The Administrative Core is central to the synergistic interaction of the projects and cores, and in fact has demonstrated the facilitation of research transactions between these groups since the proposal's original submission. As a result of this synergistic interaction, the program has generated multiple new hypotheses for She function. Through this coordination over the last 4.5 years, the research conducted by the program project has demonstrated that Shcs control adiposity, metabolism, insulin signaling, and stress resistance, and the Administrative Core has facilitated the publication of >64 manuscripts from our laboratories. The Specific Aims of this core are: to 1) provide an organizational structure to expedite and coordinate research and promote interactions among investigators; 2) monitor and regularly review the quality of research and prepare progress reports; 3) manage the fiscal components of the program project; 4) facilitate publications, presentations, and the dissemination of research results; 5) organize annual meetings by project members and an external review committee; and 6) coordinate and monitor data and resource sharing. Central to how these Aims will be achieved, Core A will organize and manage the monthly teleconference, the weekly lab meetings, the annual External Advisory Committee meeting, and the web-based server for data interchange between the seven units.