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Vestibular Regulation of Respiratory Muscle Activity

呼吸肌活动的前庭调节

基本信息

批准号：
8610910
负责人：
Carey David Balaban
金额：
$ 35.61万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
起止时间：
1998-05-01 至 2016-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8610910
关键词：
Abbreviations Abdomen Abdominal Muscles Acceleration Affect Affective Agonist Anesthesia procedures Area Behavior Brain Stem Cell Nucleus Cells Chemotherapy-Oncologic Procedure Clinical Complex Copper Sulfate Disease Dorsal Elements Emetics Environment FOS Protein Fast Blue Funding Generations Goals Grant Head Hypothalamic structure Inferior Labyrinth Lateral Limbic System Link Location Maps Mechanoreceptors Medial Military Personnel Motion Sickness Motor Motor Neurons Muscimol Nausea Nausea and Vomiting Neural Pathways Neurons Nucleus solitarius Pathway interactions Patients Pattern Poisoning Population Positioning Attribute Process Property Prosencephalon Recovery Regulation Research Respiratory Diaphragm Respiratory Muscles Reticular Formation Role Sampling Signal Transduction Site Spacecraft Stereotyping Stimulus Stomach Structure of area postrema System Techniques Tracer Training Travel Vestibular nucleus structure Viscera Visceral Vomiting Work gastrointestinal insight irritation neural circuit neuromechanism novel therapeutics parabrachial nucleus pressure public health relevance receptor research study respiratory response signal processing virtual

项目摘要

DESCRIPTION (provided by applicant): Vomiting is a consequence of a stereotyped pattern of co-contractions of the diaphragm and abdominal muscles that generate high intragastric pressures. The goal of this application is to decipher the processing of vestibular inputs by the medullary circuitry that produces vomiting, and to determine how this signal processing is affected by other inputs that can elicit emesis. Specific Aim 1 will map the locations of neurons activated during vomiting and accompanying nausea elicited by stimulation of vestibular receptors and compare the sites to those activated during emesis triggered by gastrointestinal (GI) inputs. Specific Aim 2 will employ inactivation of subregions of the vestibular nuclei (VN) to identify the area that is essential for producing vestibular-elicited vomiting. Once the brainstem regions containing neurons that participate in generating vomiting are established, subsequent experiments will ascertain the responses of cells in these areas to natural vestibular stimulation added to activation of GI receptors. Specific Aim 3 will consider neuronal responses in nucleus tractus solitarius (NTS) and the VN, which respectively receive GI and labyrinthine inputs from the periphery that can induce emesis and nausea. Specific Aim 4A will determine the responses of neurons in a region that is a component of the vomiting pattern generator: the dorsal medullary lateral tegmental field (LTF) positioned between NTS and the retrofacial nucleus. Specific Aim 4B will consider the processing of signals by PBN, which is involved in transmitting viscerosensory signals to the forebrain, to provide insights into how integration of vestibular and visceral inputs together differs in this region critical for generating nausea and medullary elements that produce vomiting. At the conclusion of Aim 4 we will have thoroughly sampled the responses of neurons to labyrinthine stimulation in the major brainstem areas known to participate in triggering and coordinating vomiting and accompanying affective responses. We will also systematically determine how vestibular signals are transformed in the emetic circuit as they are relayed from the VN to NTS and finally to LTF and the PBN. Furthermore, we will ascertain how the presence of other emetic signals affects the processing of labyrinthine inputs, and whether this processing is profoundly altered immediately before or after an episode of vomiting. As such, the studies will provide insights into the signal integration responsible for the generation of motion sickness.

描述（由申请人提供）：呕吐是横膈膜和腹部肌肉共同收缩产生高胃内压的刻板模式的结果。本应用程序的目的是破译产生呕吐的髓质电路对前庭输入的处理，并确定该信号处理如何受到引起呕吐的其他输入的影响。特异性目标1将绘制出在前庭受体刺激引起呕吐和伴随恶心时激活的神经元的位置，并将这些位置与胃肠道（GI）输入引发的呕吐时激活的神经元进行比较。特异性目标2将采用前庭核（VN）亚区失活来确定产生前庭诱发呕吐的必要区域。一旦脑干区域包含参与产生呕吐的神经元被确定，随后的实验将确定这些区域的细胞对自然前庭刺激加上GI受体的激活的反应。特异性目标3将考虑孤束核（NTS）和VN的神经元反应，它们分别接受来自外周的GI和迷路输入，可诱导呕吐和恶心。特异性Aim 4A将确定呕吐模式产生的一个组成部分的神经元的反应：位于NTS和面后核之间的背髓外侧被盖区（LTF）。具体的Aim 4B将考虑PBN的信号处理，它参与将内脏感觉信号传递到前脑，以深入了解前庭和内脏输入在产生恶心和产生呕吐的髓质元素的关键区域的整合如何不同。在Aim 4的结论中，我们将对已知参与触发和协调呕吐以及伴随的情感反应的主要脑干区域的迷路刺激神经元的反应进行彻底采样。我们还将系统地确定前庭信号从VN传递到NTS，最后传递到LTF和PBN时，前庭信号在呕吐回路中是如何转换的。此外，我们将确定其他呕吐信号的存在如何影响迷宫输入的处理，以及这种处理是否在呕吐前或呕吐后立即发生深刻改变。因此，这些研究将提供对产生晕动病的信号整合的见解。

项目成果

期刊论文数量（38）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Vestibulo-sympathetic responses.

DOI：
10.1002/cphy.c130041
发表时间：
2014-04
期刊：
Comprehensive Physiology
影响因子：
5.8
作者：
Yates BJ;Bolton PS;Macefield VG
通讯作者：
Macefield VG

Integrative responses of neurons in parabrachial nuclei to a nauseogenic gastrointestinal stimulus and vestibular stimulation in vertical planes.

DOI：
10.1152/ajpregu.00680.2011
发表时间：
2012-04
期刊：
American journal of physiology. Regulatory, integrative and comparative physiology
影响因子：
0
作者：
Takeshi Suzuki;Y. Sugiyama;B. Yates
通讯作者：
Takeshi Suzuki;Y. Sugiyama;B. Yates

Integration of vestibular and gastrointestinal inputs by cerebellar fastigial nucleus neurons: multisensory influences on motion sickness.

DOI：
10.1007/s00221-014-3898-9
发表时间：
2014-08
期刊：
EXPERIMENTAL BRAIN RESEARCH
影响因子：
2
作者：
Catanzaro, Michael F.;Miller, Daniel J.;Cotter, Lucy A.;McCall, Andrew A.;Yates, Bill J.
通讯作者：
Yates, Bill J.

Integration of nonlabyrinthine inputs by the vestibular system: role in compensation following bilateral damage to the inner ear.

前庭系统非迷路输入的整合：在内耳双侧损伤后的补偿中的作用。