Investigating a role for TAM receptor signaling in demyelination

研究 TAM 受体信号传导在脱髓鞘中的作用

• 批准号: nhmrc : 1031450
• 负责人: Dr Judith Field
• 金额: $ 29.63万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigating-role-tam-signaling-demyelination/110806
• 关键词: Investigating; role; TAM; receptor; signaling

In Multiple Sclerosis brain cells are damaged and myelin is lost in a process known as demyelination. Two proteins, called Gas6 and Protein S, can influence cells involved in MS, by signalling through proteins called TAMs. We have shown that Gas6 can affect the severity of demyelination in mice, and that TAMs can affect the response of cells to interferon-beta, a major MS treatment. We plan to further study the effects of these proteins during demyelination, and their interaction with interferon-beta.

在多发性硬化症中，脑细胞受损，髓鞘在一个被称为脱髓鞘的过程中丢失。两种名为Gas6和S的蛋白质可以通过名为TAMs的蛋白质发出信号来影响参与MS的细胞。我们已经证明，Gas6可以影响小鼠脱髓鞘的严重程度，TAMS可以影响细胞对干扰素-β的反应，干扰素-β是MS的主要治疗方法。我们计划进一步研究这些蛋白质在脱髓鞘过程中的作用，以及它们与干扰素-β的相互作用。