Functional assessment of CD40 in the development of Multiple Sclerosis

CD40 在多发性硬化症发展中的功能评估

• 批准号: nhmrc : 1065157
• 负责人: Dr Judith Field
• 金额: $ 34.8万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/functional-assessment-cd40-multiple-sclerosis/455155
• 关键词: Functional; assessment; CD40; development; Multiple

Many of the genes which affect susceptibility to Multiple Sclerosis (MS) have recently been identified. Two of these genes were first discovered in an Australian study published in Nature Genetics in 2009. One of these is CD40, which controls immune cell activation. In this project we aim to establish how the genetic variant identified affects the function of the CD40 gene in MS. CD40 may prove to be a good therapeutic target, with agents available to modulate CD40 available already.

许多影响多发性硬化症（MS）易感性的基因最近已被确定。其中两个基因是在2009年发表在《自然遗传学》上的一项澳大利亚研究中首次发现的。其中之一是CD40，它控制免疫细胞的激活。在这个项目中，我们的目标是确定所鉴定的遗传变异如何影响ms中CD40基因的功能，CD40可能被证明是一个很好的治疗靶点，目前已有可用于调节CD40的药物。