Feasibility of an Exercise and Dietary Intervention in Men on Prolonged ADT

男性长期 ADT 运动和饮食干预的可行性

基本信息

  • 批准号:
    8467693
  • 负责人:
  • 金额:
    $ 7.01万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2012
  • 资助国家:
    美国
  • 起止时间:
    2012-06-01 至 2015-05-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Androgen-deprivation therapy is the foundation of treatment for men with metastatic prostate cancer (PC) and is now frequently incorporated into multimodality strategies for the curative treatment of locally advanced PC. Unfortunately, the catabolic effects of ADT result in significant morbidity including loss of lean muscle mass, increased fat mass, reduced muscle strength, and lower bone mineral density. In turn, these adverse effects of ADT are linked with functional decline and frailty. Emerging evidence also suggests that men on ADT are at greater risk for cardiovascular disease and the onset of metabolic syndrome. Thus, it is becoming increasingly clear that PC patients endure long and lingering impacts on physical function, health status, and quality of life (QOL) that accompany ADT as a "trade-off" for more effective cancer control and extended longevity. It has been proposed that lifestyle modification, including change in exercise and dietary behaviors, may offset, or even reverse, the adverse effects that accompany long-term administration of ADT. With a growing clinical focus upon improvements in QOL in cancer survivorship, there is a critical need to identify lifestyle interventions that are effective in offsetting the adverse effets of ADT and minimizing the risk of functional decline and chronic disease in PC patients undergoing treatment. Our long term research goal is to develop innovative and effective lifestyle interventions for the treatment of PC patients undergoing prolonged ADT. However, empirical evidence documenting the efficacy of theory-based, personalized exercise and dietary interventions for improving functional limitations, chronic disease risk factors, and QOL in men on prolonged ADT is limited. Additionally, the pathways through which lifestyle, exercise, and dietary interventions produce improvements in these clinically relevant outcomes have yet to be defined. Our central hypotheses are that: 1) a theory-driven, personalized exercise and dietary intervention will produce superior improvements in functional limitations, body composition, and quality of life relative to a standard of care treatment approach and 2) the intervention effects o functional limitations and QOL will be indirect operating through improvements in self-efficacy beliefs and intermediate disablement process model outcomes. The objective for this current application is to determine the feasibility and preliminary efficacy of an exercise and dietary intervention upon functional, disease, and QOL outcomes in PC patients undergoing ADT. Upon completion of this investigation, the primary positive impact of our findings would be evidence-based scientific verification of the efficacy of lifestyle, exercise, and dietary interventions in prevention and treatment of the adverse effects of prolonged ADT in PC patients. This proposed investigation has the potential to rapidly impact the medical community and their approach to ADT. Should the personalized approach to exercise and dietary modification improve outcomes, we will have the evidence necessary to alter current clinical practice of men on ADT.
描述(由申请人提供):雄激素剥夺治疗是转移性前列腺癌(PC)男性治疗的基础,现在经常被纳入局部晚期PC治愈性治疗的多模态策略中。 不幸的是,ADT的分解代谢作用导致显著的发病率,包括瘦肌肉质量损失、脂肪质量增加、肌肉强度降低和骨矿物质密度降低。反过来,ADT的这些不良反应与功能下降和虚弱有关。新出现的证据还表明,接受ADT治疗的男性患心血管疾病和代谢综合征的风险更大。因此,越来越清楚的是,PC患者忍受对身体功能、健康状况和生活质量(QOL)的长期和挥之不去的影响,这些影响伴随ADT作为更有效的癌症控制和延长寿命的“权衡”。有人提出,生活方式的改变,包括运动和饮食行为的改变,可能会抵消,甚至逆转,伴随着长期服用ADT的不良反应。随着临床越来越关注癌症生存率的QOL改善,迫切需要确定生活方式干预措施,这些干预措施可有效抵消ADT的不良影响,并最大限度地降低接受治疗的PC患者的功能下降和慢性疾病风险。我们的长期研究目标是开发创新和有效的生活方式干预措施,用于治疗接受长期ADT的PC患者。 然而,经验证据证明基于理论的个性化运动和饮食干预措施对改善长期ADT男性的功能限制、慢性疾病危险因素和QOL的疗效有限。此外,生活方式、运动和饮食干预改善这些临床相关结果的途径尚未确定。我们的中心假设是:1)理论驱动的,个性化的运动和饮食干预将产生上级改善功能限制,身体成分,和生活质量相对于标准的护理治疗方法和2)功能限制和生活质量的干预效果将通过改善自我效能信念和中间残疾过程模型的结果间接运作。本申请的目的是确定运动和饮食干预对接受ADT的PC患者的功能、疾病和QOL结局的可行性和初步疗效。在完成这项调查后,我们的研究结果的主要积极影响将是以证据为基础的科学验证的生活方式,运动和饮食干预在预防和治疗PC患者长期ADT的不良反应的有效性。这项拟议的调查有可能迅速影响医学界及其ADT方法。如果个性化的运动和饮食调整方法可以改善结果,我们将有必要的证据来改变目前男性ADT的临床实践。

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Effects of a lifestyle intervention on body composition in prostate cancer patients on androgen deprivation therapy.
生活方式干预对前列腺癌患者身体成分的影响对雄激素剥夺治疗。
  • DOI:
    10.1002/crt2.13
  • 发表时间:
    2020-04
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Resistance exercise interventions during and following cancer treatment: a systematic review.
  • DOI:
    10.12788/j.suponc.0002
  • 发表时间:
    2013-06
  • 期刊:
  • 影响因子:
    0
  • 作者:
    B. Focht;S. Clinton;S. Devor;M. Garver;Alexander R. Lucas;J. Thomas-Ahner;E. Grainger
  • 通讯作者:
    B. Focht;S. Clinton;S. Devor;M. Garver;Alexander R. Lucas;J. Thomas-Ahner;E. Grainger
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Brian Carl Focht其他文献

Brian Carl Focht的其他文献

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{{ truncateString('Brian Carl Focht', 18)}}的其他基金

Comprehensive Lifestyle Intervention Program for Knee Osteoarthritis Patients (CLIP-OA)
膝骨关节炎患者综合生活方式干预计划(CLIP-OA)
  • 批准号:
    9251715
  • 财政年份:
    2016
  • 资助金额:
    $ 7.01万
  • 项目类别:
Comprehensive Lifestyle Intervention Program for Knee Osteoarthritis Patients (CLIP-OA)
膝骨关节炎患者综合生活方式干预计划(CLIP-OA)
  • 批准号:
    9903176
  • 财政年份:
    2016
  • 资助金额:
    $ 7.01万
  • 项目类别:
Feasibility of an Exercise and Dietary Intervention in Men on Prolonged ADT
男性长期 ADT 运动和饮食干预的可行性
  • 批准号:
    8323748
  • 财政年份:
    2012
  • 资助金额:
    $ 7.01万
  • 项目类别:
Promoting maintenance of physical activity in older knee osteoarthritis patients
促进老年膝骨关节炎患者保持体力活动
  • 批准号:
    7468704
  • 财政年份:
    2008
  • 资助金额:
    $ 7.01万
  • 项目类别:
Promoting maintenance of physical activity in older knee osteoarthritis patients
促进老年膝骨关节炎患者保持体力活动
  • 批准号:
    7618422
  • 财政年份:
    2008
  • 资助金额:
    $ 7.01万
  • 项目类别:

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