Developmental Research Program

MSCP孢子发育研究计划（DRP）提供种子资金，用于探索黑色素瘤和其他皮肤癌的有前途的新研究，特别是目前尚未从事该领域研究的研究人员。DRP每年征求两次建议，并使用同行评议的评分系统来确定资助建议的优先次序。DRP董事和执行委员会、内部咨询委员会和外部咨询委员会参与审查过程，如果需要专门的审查专家，还可以与患者倡导者和任何其他专家一起参与。在过去的资助期间，MSCP SPORE资助了9个DRP项目，包括基础研究、转化研究和临床研究。DRP主任跟踪成功申请的进度，并为受资助的研究人员分配导师，以确保他们从MSCP SPORE核心（行政核心A、生物标本核心B、生物统计学核心C和信息学核心D）获得所需的服务，并有效地融入SPORE计划。获奖者在一年的资助后向SPORE调查人员展示他们的研究成果，有资格获得第二年的支持。在转化、影响和创新方面的进展将决定DRP项目是否值得晋升为完整的《孢子》项目；在过去的资助期内，由DRP资助的富有成效和创新的研究奖励给博士。Hassane Zarour和Soldano Ferrone已经晋升为一个完整的项目。项目3，在此更新申请中。获奖者还被建议在适当的时候准备孢子机制之外的资助申请，并被允许使用孢子核心资源来帮助这项工作。drp支持的研究已经获得了3项NCI奖（R01CA154728, R01CA157467, R01CA169118）和一项由匹兹堡大学临床转化科学研究所基础临床合作研究试点项目资助的试点奖。还有一些基于前一个资助期DRP结果提交或计划的资助申请，包括一个R21和两个额外的R01申请。

The MSCP SPORE Developmental Research Program (DRP) provides seed funding to explore promising novel research in melanoma and other skin cancers, particularly by investigators not currently engaged in research in this area. The DRP solicits proposals twice a year and to use a peer-reviewed scoring system to prioritize proposals for funding. The DRP Directors and Executive Committee, Internal Advisory Board and External Advisory Board participate in the review process, together with the Patient Advocates and any additional experts who may be called upon if special reviewer expertise is necessary. During the past grant period, the MSCP SPORE funded 9 DRP projects in basic, translational, and clinical research. The DRP Directors track the progress of the successful applications and assign mentors to funded investigators to ensure that they obtain any needed services from the MSCP SPORE Cores (Administrative Core A, Biospecimen Core B, Biostatistics Core C, and Informatics Core D) and that they are effectively integrated into the SPORE program. Awardees present their research results to the SPORE investigators after one year of funding to be eligible for a second year of support. Progress toward translation as well as impact and innovation will determine whether DRP projects are found to merit promotion to full SPORE projects; in the past funding period, productive and innovative research funded by DRP awards to Drs. Hassane Zarour and Soldano Ferrone has been promoted to a full project. Project 3, in this renewal application. Awardees are also advised as appropriate in the preparation of grant applications for funding outside the SPORE mechanism and given access to SPORE Core resources to aid in this endeavor. DRP-supported research has led to 3 NCI awards (R01CA154728, R01CA157467, R01CA169118) and a pilot award funded by the University of Pittsburgh Clinical Translational Science Institute Basic to Clinical Collaborative Research Pilot Program. There are also several grant applications submitted or planned based on DRP results from the previous grant period, including an R21 and two additional R01 applications.