Developmental Research Program

发展研究计划

• 批准号: 9091460
• 负责人: John Munn Kirkwood
• 金额: $ 6.59万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-26 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9091460
• 关键词: Advocate; Antibodies; Applications Grants; Area; Award; BRAF gene; Basic Science; Biostatistics Core; Chicago; Clinical; Clinical Research; Collaborations; Cutaneous Melanoma; Data; Development; Developmental Therapeutics Program; Ensure; Funding; Grant; Immunologist; Immunosuppression; Immunotherapy; Informatics; Institutes; Institution; Interferon Alfa-2b; Leadership; Major Histocompatibility Complex; Medical Oncologist; Mentors; Molecular; Patients; Peer Review; Pilot Projects; Preparation; Principal Investigator; Process; Program Research Project Grants; Research; Research Personnel; Research Support; Resistance; Resources; Rewards; Seeds; Services; Skin Cancer; Specialist; Surgical Oncologist; System; T-Lymphocyte; Translational Research; Translations; Treatment outcome; Universities; Vaccines; Virginia; base; broadening participation research; cancer diagnosis; cancer research center director; chemotherapy; high reward; high risk; improved; inhibitor/antagonist; innovation; interest; meetings; melanoma; novel; programs; success; tumor; tumor microenvironment

The MSCP SPORE Developmental Research Program (DRP) provides seed funding to explore promising novel research in melanoma and other skin cancers, particularly by investigators not currently engaged in research in this area. The DRP solicits proposals twice a year and to use a peer-reviewed scoring system to prioritize proposals for funding. The DRP Directors and Executive Committee, Internal Advisory Board and External Advisory Board participate in the review process, together with the Patient Advocates and any additional experts who may be called upon if special reviewer expertise is necessary. During the past grant period, the MSCP SPORE funded 9 DRP projects in basic, translational, and clinical research. The DRP Directors track the progress of the successful applications and assign mentors to funded investigators to ensure that they obtain any needed services from the MSCP SPORE Cores (Administrative Core A, Biospecimen Core B, Biostatistics Core C, and Informatics Core D) and that they are effectively integrated into the SPORE program. Awardees present their research results to the SPORE investigators after one year of funding to be eligible for a second year of support. Progress toward translation as well as impact and innovation will determine whether DRP projects are found to merit promotion to full SPORE projects; in the past funding period, productive and innovative research funded by DRP awards to Drs. Hassane Zarour and Soldano Ferrone has been promoted to a full project. Project 3, in this renewal application. Awardees are also advised as appropriate in the preparation of grant applications for funding outside the SPORE mechanism and given access to SPORE Core resources to aid in this endeavor. DRP-supported research has led to 3 NCI awards (R01CA154728, R01CA157467, R01CA169118) and a pilot award funded by the University of Pittsburgh Clinical Translational Science Institute Basic to Clinical Collaborative Research Pilot Program. There are also several grant applications submitted or planned based on DRP results from the previous grant period, including an R21 and two additional R01 applications.

MSCP孢子发育研究计划（DRP）提供了种子资金，以探索有希望的黑色素瘤和其他皮肤癌的新型研究，尤其是目前未从事该领域研究的研究人员。 DRP每年两次提议提案，并使用同行评审的评分系统来优先考虑资金提案。 DRP董事和执行委员会，内部顾问委员会和外部咨询委员会与患者的拥护者以及任何其他专家一起参加了审查过程，如果需要特别审核者的专业知识，他们可能会受到要求。在过去的赠款期间，MSCP孢子在基本，转化和临床研究中资助了9个DRP项目。 DRP 董事跟踪成功的应用程序的进度，并将导师分配给资助的研究人员，以确保他们从MSCP孢子核心（行政核心A，Biospececimen Core B，Biospecimen Core B，BioScemen Core Core C和Inlernatics Core d）中获得任何所需的服务，并有效地集成在孢子计划中。在经过一年的资金后，获奖者向孢子调查人员提供了研究结果，有资格获得第二年的支持。向翻译以及影响和创新方面的进展将决定是否发现DRP项目值得推广到全孢子项目；在过去的资金期间，由DRP颁奖典礼授予DRS的生产和创新研究。 Hassane Zarour和 Soldano Ferrone已晋升为一个完整的项目。项目3，在此续签应用中。还建议获奖者在准备资金以外的资金申请范围之外的赠款申请，并获得孢子核心资源以帮助这项工作。 DRP支持的研究导致了3个NCI奖（R01CA154728，R01CA157467，R01CA169118），并获得了匹兹堡大学临床翻译科学学院基础临床研究所临床合作研究PILOT计划的试点奖。还根据上一批赠款期的DRP结果提交或计划了几个赠款申请，包括R21和另外两个R01申请。