Developmental Research Program

发展研究计划

• 批准号: 9091460
• 负责人: John Munn Kirkwood
• 金额: $ 6.59万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-26 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9091460
• 关键词: Advocate; Antibodies; Applications Grants; Area; Award; BRAF gene; Basic Science; Biostatistics Core; Chicago; Clinical; Clinical Research; Collaborations; Cutaneous Melanoma; Data; Development; Developmental Therapeutics Program; Ensure; Funding; Grant; Immunologist; Immunosuppression; Immunotherapy; Informatics; Institutes; Institution; Interferon Alfa-2b; Leadership; Major Histocompatibility Complex; Medical Oncologist; Mentors; Molecular; Patients; Peer Review; Pilot Projects; Preparation; Principal Investigator; Process; Program Research Project Grants; Research; Research Personnel; Research Support; Resistance; Resources; Rewards; Seeds; Services; Skin Cancer; Specialist; Surgical Oncologist; System; T-Lymphocyte; Translational Research; Translations; Treatment outcome; Universities; Vaccines; Virginia; base; broadening participation research; cancer diagnosis; cancer research center director; chemotherapy; high reward; high risk; improved; inhibitor/antagonist; innovation; interest; meetings; melanoma; novel; programs; success; tumor; tumor microenvironment

The MSCP SPORE Developmental Research Program (DRP) provides seed funding to explore promising novel research in melanoma and other skin cancers, particularly by investigators not currently engaged in research in this area. The DRP solicits proposals twice a year and to use a peer-reviewed scoring system to prioritize proposals for funding. The DRP Directors and Executive Committee, Internal Advisory Board and External Advisory Board participate in the review process, together with the Patient Advocates and any additional experts who may be called upon if special reviewer expertise is necessary. During the past grant period, the MSCP SPORE funded 9 DRP projects in basic, translational, and clinical research. The DRP Directors track the progress of the successful applications and assign mentors to funded investigators to ensure that they obtain any needed services from the MSCP SPORE Cores (Administrative Core A, Biospecimen Core B, Biostatistics Core C, and Informatics Core D) and that they are effectively integrated into the SPORE program. Awardees present their research results to the SPORE investigators after one year of funding to be eligible for a second year of support. Progress toward translation as well as impact and innovation will determine whether DRP projects are found to merit promotion to full SPORE projects; in the past funding period, productive and innovative research funded by DRP awards to Drs. Hassane Zarour and Soldano Ferrone has been promoted to a full project. Project 3, in this renewal application. Awardees are also advised as appropriate in the preparation of grant applications for funding outside the SPORE mechanism and given access to SPORE Core resources to aid in this endeavor. DRP-supported research has led to 3 NCI awards (R01CA154728, R01CA157467, R01CA169118) and a pilot award funded by the University of Pittsburgh Clinical Translational Science Institute Basic to Clinical Collaborative Research Pilot Program. There are also several grant applications submitted or planned based on DRP results from the previous grant period, including an R21 and two additional R01 applications.

MSCP孢子发育研究计划(DRP)提供种子资金，以探索黑色素瘤和其他皮肤癌的有前景的新研究，特别是目前没有从事这一领域研究的研究人员。DRP每年征求两次建议，并使用同行评议的评分系统来确定资助建议的优先顺序。DRP董事和执行委员会、内部咨询委员会和外部咨询委员会与患者权益倡导者和任何可能需要特殊审查员专业知识的其他专家一起参与审查过程。在过去的赠款期间，MSCP孢子资助了9个基础、翻译和临床研究的DRP项目。《DRP》 董事们跟踪成功申请的进展，并向受资助的调查人员指派导师，以确保他们从MSCP孢子核心(行政核心A、生物科学核心B、生物统计核心C和信息学核心D)获得任何所需的服务，并确保它们有效地整合到孢子计划中。获奖者在一年的资助后向孢子研究人员提交他们的研究成果，有资格获得第二年的支持。翻译方面的进展以及影响和创新将决定DRP项目是否值得推广到全孢子项目；在过去的资助期间，由DRP奖励给Hassane Zarour博士和 索尔达诺·费罗内已经被提升为一个完整的项目。项目3，在此续签申请中。在为孢子机制以外的资金准备赠款申请时，也会酌情建议获奖者，并允许他们获得孢子核心资源，以帮助这项工作。DRP支持的研究已获得3个NCI奖项(R01CA154728、R01CA157467、R01CA169118)和一个由匹兹堡大学临床转化科学研究所基础到临床协作研究试点项目资助的试点奖项。还有一些赠款申请是根据上一批赠款期间的DRP结果提交或计划的，其中包括一份R21和另外两份R01申请。