Einstein Lupus Cohort Core

爱因斯坦狼疮队列核心

• 批准号: 8590507
• 负责人: THOMAS TUSCHL
• 金额: $ 40.36万
• 依托单位: ROCKEFELLER UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8590507
• 关键词: Affect; Archives; Autoimmune Process; B lymphocyte immortalization; Cell Separation; Clinical; Collection; Core Facility; DNA; Data; Databases; Elements; Epidemiology; Family; Family member; Future; Genomics; Grant; Lupus; Medical History; Patients; Protocols documentation; RNA; Recording of previous events; Regulation; Research Personnel; Resources; Ribonucleoproteins; Secure; Serum; Specimen; Stress; Systemic Lupus Erythematosus; Testing; Urine; cohort; data integrity; disorder control; human subject; interoperability; programs

Core Leader: Chaim Putterman. A central element of the U19 grant is the collection and characterization of patients with systemic lupus erythematosus (SLE), related autoimmune conditions, and normal controls. This requires protocol-driven identification of subjects, standardized recording of medical history, epidemiological information, family history, and the collection and storage of high-quality biospecimens. Underpinning all of this is a secure, accessible database assuring data integrity and interoperability. The specific aims of the Clinical Resource Core (CRC) are: 1. Recruitment of subjects with SLE and related conditions, disease controls, and healthy controls; 2. Collection of demographic, clinical, and epidemiological data with storage in a secure, confidential database; 3. Collection and storage of serum, urine, DNA, and RNA for distribution to researchers in this program, from affected and unaffected family members. 4. Immortalization of B cells to provide a resource of cells for isolation of stress-related RNPs and testing of immunomodulatory effects

核心领导人：Chaim Putterman。U19补助金的一个核心要素是收集和表征系统性红斑狼疮（SLE）患者、相关自身免疫性疾病和正常对照。这需要协议驱动 受试者识别，规范化病史记录，流行病学信息，家庭 历史，以及收集和储存高质量的生物标本。支撑这一切的是一个安全， 可访问的数据库，确保数据的完整性和互操作性。临床资源的具体目标 核心（CRC）是： 1.招募患有系统性红斑狼疮和相关疾病的受试者、疾病对照者和健康对照者; 2.收集人口统计学、临床和流行病学数据，并将其存储在安全、保密的 数据库; 3.收集和储存血清、尿液、DNA和RNA，以分发给本领域的研究人员。 受影响和未受影响的家庭成员。 4.使B细胞永生化以提供用于分离应激相关RNP的细胞资源， 免疫调节作用试验