Einstein Lupus Cohort Core

核心领导者：Chaim Putterman。U19赠款的一个核心要素是收集和鉴定系统性红斑狼疮(SLE)患者、相关的自身免疫性疾病和正常对照。这需要协议驱动 确定受试者、标准化记录病史、流行病学信息、家庭 历史，以及高质量生物标本的收集和储存。支撑这一切的是一个安全的、 可访问的数据库，确保数据的完整性和互操作性。临床资源的具体目标 核心(CRC)为： 1.招募系统性红斑狼疮及相关疾病、疾病控制和健康对照受试者； 2.收集人口、临床和流行病学数据，并将其存储在安全、保密的 数据库； 3.收集和储存血清、尿液、DNA和RNA，以便分发给本组织的研究人员 计划，来自受影响和未受影响的家庭成员。 4.使B细胞永生化，为分离与应激相关的RNPs和 免疫调节作用的检测

Core Leader: Chaim Putterman. A central element of the U19 grant is the collection and characterization of patients with systemic lupus erythematosus (SLE), related autoimmune conditions, and normal controls. This requires protocol-driven identification of subjects, standardized recording of medical history, epidemiological information, family history, and the collection and storage of high-quality biospecimens. Underpinning all of this is a secure, accessible database assuring data integrity and interoperability. The specific aims of the Clinical Resource Core (CRC) are: 1. Recruitment of subjects with SLE and related conditions, disease controls, and healthy controls; 2. Collection of demographic, clinical, and epidemiological data with storage in a secure, confidential database; 3. Collection and storage of serum, urine, DNA, and RNA for distribution to researchers in this program, from affected and unaffected family members. 4. Immortalization of B cells to provide a resource of cells for isolation of stress-related RNPs and testing of immunomodulatory effects