REAGENT / VECTOR CORE

试剂/载体核心

• 批准号: 8504904
• 负责人: GREGORY A. VIGLIANTI
• 金额: --
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8504904
• 关键词: Antibodies; Antigens; Autoantibodies; Autoantigens; Biological; Complex; Endotoxins; Goals; Individual; Nucleic Acids; Quality Control; Reagent; Systemic Lupus Erythematosus; Toll-like receptors; Viral Vector; programs; systemic autoimmune disease; vector

The overarching main objective of this Program Project is to understand the mechanisms through which autoantigen/autoantibody complexes contribute to the initiation and/or maintainence of systemic lupus erythematosus. The various projects in the Program will rely, in part, on a number of antigens, antibodies and viral vectors to carry out the proposed specific aims. The successful completion of these aims has been and will continue to be enhanced by the availability of a set of highly defined, quality controlled reagents that will be produced by this Core.

本计划项目的首要目标是了解 自身抗原/自身抗体复合物促进系统性狼疮的发生和/或发展 红斑该计划中的各种项目将部分依赖于一些抗原，抗体和 病毒载体来实现所提出的具体目标。这些目标的成功实现， 将继续得到加强的一套高度定义，质量控制的试剂， 由这个核心产生。