Rotator Cuff Tears: Optimizing Diagnosis and Treatment Strategies

肩袖撕裂：优化诊断和治疗策略

• 批准号: 8523795
• 负责人: Nitin B Jain
• 金额: $ 13.24万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8523795
• 关键词: Accounting; Address; Age; Area; Articular Range of Motion; Award; Biometry; Clinical; Cohort Studies; Comorbidity; Consensus; Cost Savings; Decision Making; Detection; Diagnosis; Diagnostic; Disease; Elderly; Elements; Ensure; Environment; Epidemiology; Evaluation; Failure; Funding; Future; Goals; Health Care Costs; Hospitals; Image; Individual; Infiltration; International; Investigation; Knowledge; Learning; Literature; Magnetic Resonance Imaging; Medicine; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Modality; Musculoskeletal Diseases; Operative Surgical Procedures; Orthopedics; Outcome; Outpatients; Pain; Participant; Pathology; Patients; Physical Examination; Physicians; Process; Productivity; Prognostic Factor; Qualifying; Randomized Clinical Trials; Randomized Controlled Trials; Recording of previous events; Recruitment Activity; Rehabilitation therapy; Research; Research Methodology; Research Personnel; Research Training; Rotator Cuff; Sample Size; Sampling; Sensitivity and Specificity; Services; Shoulder; Shoulder Pain; Specificity; Sports Medicine; Surgeon; Surveys; Symptoms; Tendon structure; Testing; Thick; Time; Training; Ultrasonography; Variant; Visit; Woman; Work; base; clinical Diagnosis; clinical decision-making; design; diagnostic accuracy; disability; evidence base; experience; follow-up; functional improvement; functional outcomes; interest; medical schools; patient oriented research; programs; prospective; radiologist; success; treatment strategy

DESCRIPTION (provided by applicant): Rotator cuff tears are the most common cause of shoulder disability and pain accounting for 4.5 million physician visits and 75,000 surgeries annually. There is paucity of evidence addressing the diagnostic value of clinical history and physical examination of the shoulder. Consequently, magnetic resonance imaging (MRI) is used frequently to make a diagnosis of rotator cuff tear. Shoulder ultrasound is portable, office-based, and ~ 75% less expensive than MRI for diagnosis of rotator cuff tears. However, the diagnostic accuracy of ultrasound has not been established. This study will assess the sensitivity and specificity of a combination of select symptoms, physical examination findings, and ultrasound as compared to MRI and expert clinical diagnosis as a criterion standard. There is little evidence on the best treatment approach for rotator cuff tears and on factors associated with better outcomes of operative and non-operative treatment. There is no evidence from randomized clinical trials in this area. Current decision-making on non-operative treatment versus surgery is based largely on anecdotal clinical experience. Our study will determine predictors of pain and functional outcomes of non-operative and operative treatment of rotator cuff tears at two year follow-up period. Results from our study will provide evidence to inform clinical decision-making. This work will also lay a framework for a randomized controlled trial of surgery versus non-operative treatment which will be proposed in the final years of this award. The candidate's clinical background in Rehabilitation Medicine, and prior work in musculoskeletal diseases and patient-oriented studies is ideally suited for this mentored patient-oriented research program. His research and clinical environments at Brigham and Women's Hospital and Harvard Medical School offer him stimulating and rich learning opportunities. During the K23 award period, the candidate will obtain advanced training in research methodology, and shoulder disorders and imaging. The candidate will benefit from mentorship of Dr. Jeffrey N. Katz, a leading international expert in musculoskeletal diseases research. The candidate's mentoring team will also include Dr. Elena Losina, a biostatistician and independently funded R01 investigator, with extensive experience in mentoring of junior investigators; Dr. Laurence Higgins, an international clinical expert in shoulder disorders and Chief of Sports Medicine and Shoulder Surgery at Brigham and Women's Hospital, and; Dr. Joel Newman, a radiologist with expertise in shoulder ultrasound. The candidate with his prior training, research productivity, and clinical interests is uniquely situated to deliver the proposed research agenda and benefit from a highly qualified mentoring team.

描述（由申请人提供）：肩袖撕裂是肩关节残疾和疼痛的最常见原因，每年有450万次医生就诊和75，000次手术。缺乏证据说明肩关节的临床病史和体格检查的诊断价值。因此，磁共振成像（MRI）经常用于诊断肩袖撕裂。肩关节超声是便携式的，基于办公室，比MRI便宜约75%，用于诊断肩袖撕裂。然而，超声诊断的准确性尚未建立。本研究将评估选择症状、体格检查结果和超声相结合的灵敏度和特异性，并将MRI和专家临床诊断作为标准。关于肩袖撕裂的最佳治疗方法以及与手术和非手术治疗的更好结局相关的因素，几乎没有证据。在这方面没有来自随机临床试验的证据。目前关于非手术治疗与手术治疗的决策主要基于轶事临床经验。我们的研究将在两年的随访期内确定肩袖撕裂的非手术和手术治疗的疼痛和功能结局的预测因素。我们的研究结果将为临床决策提供依据。这项工作还将为手术与非手术治疗的随机对照试验奠定框架，该试验将在该奖项的最后几年提出。候选人在康复医学方面的临床背景，以及先前在肌肉骨骼疾病和以患者为导向的研究方面的工作非常适合这个指导以患者为导向的研究项目。他在布里格姆妇女医院和哈佛医学院的研究和临床环境为他提供了激励和丰富的学习机会。在K23奖学金期间，候选人将获得研究方法，肩部疾病和成像方面的高级培训。候选人将受益于杰弗里N博士的指导。Katz博士说，他是肌肉骨骼疾病研究领域的国际领先专家。候选人的指导团队还将包括Elena Losina博士，一位生物统计学家和独立资助的R 01研究者，在指导初级研究者方面具有丰富的经验; Laurence Higgins博士，一位肩关节疾病的国际临床专家，布莱根妇女医院运动医学和肩关节手术主任; Joel纽曼博士，一位具有肩关节超声专业知识的放射科医生。候选人与他以前的培训，研究生产力和临床利益是独特的位置，以提供拟议的研究议程，并从一个高素质的指导团队受益。