Fetal Microchimerism in the Human Brain
人脑中的胎儿微嵌合现象
基本信息
- 批准号:8413044
- 负责人:
- 金额:$ 20.76万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-02-01 至 2015-01-31
- 项目状态:已结题
- 来源:
- 关键词:AdultAdverse effectsAffectAgeAutoimmune ProcessAutopsyBiological AssayBiologyBloodBrainBrain regionCardiac MyocytesCell CountCellsChildDNADegenerative DisorderDevelopmentDiseaseEffector CellEpilepsyEvaluationFamily memberFemaleFetusFoundationsGenetic PolymorphismHealthHeartHepatocyteHumanImmuneImmune TargetingImmunologic SurveillanceIndividualKidneyKnowledgeLifeLiverLocationMicrochimerismMothersMusOrganPancreasPatientsPharmaceutical PreparationsPhenotypePregnancyPrevalenceRefractorySiblingsSourceSpecimenSpleenTimeTwin Multiple BirthWomanWorkfetalfetus cellhuman diseasehuman femaleisletmaleneoplasticresearch studytissue repairtraffickingtumor
项目摘要
PROJECT SUMMARY/ABSTRACT
Microchimerism (Mc) refers to harboring a small amount of cells or DNA from a genetically distinct individual.
Many years after the physical union of mother and child ends fetal Mc is found in the mother and maternal Mc
is found in her progeny. Fetal Mc and maternal Mc have been identified in children and adults, in blood and
organs including heart, liver, spleen, kidney and pancreas. Despite the importance of the brain to human
health and function a fundamental gap in knowledge exists for Mc in the human brain. That human brain is
likely to contain fetal Mc in women and maternal Mc in her progeny is supported by recent experimental
studies in which fetal Mc was identified in the maternal mouse brain and maternal Mc in the fetal mouse brain.
Moreover, in experimental and human studies Mc appears to have the capacity to differentiate creating, for
example, cardiac myocytes in the heart, islet b cells in the pancreas and hepatocytes in the liver. Studies in
this proposal will for the first time identify and characterize naturally acquired fetal Mc and maternal Mc in the
human brain. To establish fundamental initial knowledge fetal Mc prevalence, quantity and cell phenotypes will
be determined across age and according to specific brain regions. To establish initial information about
maternal Mc surgically excised brain specimens will be studied from patients with medication refractory
epilepsy for whom family members participate. In these studies maternal Mc will be specifically assayed by
HLA and other polymorphism specific quantitative PCR (qPCR). Participation of all family members will permit
further evaluation for other potential Mc sources including from an older sibling, passed by the mother to the
fetus of a subsequent pregnancy, or a vanished twin. The ways in which Mc could affect the human brain are
multiple and diverse, both to the benefit and detriment of the individual. If naturally acquired Mc is a basic
aspect of biology as we hypothesize, the proposed work will have created a foundation from which diverse
disorders of the human brain can be investigated, including autoimmune, neoplastic, developmental and
degenerative conditions.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
J. Lee Nelson其他文献
Forward and reverse inheritance — the yin and the yang
正向和反向继承——阴与阳
- DOI:
10.1038/nrrheum.2017.88 - 发表时间:
2017-06-08 - 期刊:
- 影响因子:32.700
- 作者:
J. Lee Nelson;Nathalie C. Lambert - 通讯作者:
Nathalie C. Lambert
133: At diagnosis, total cell-free DNA concentration is elevated in preeclampsia versus controls
- DOI:
10.1016/j.ajog.2019.11.149 - 发表时间:
2020-01-01 - 期刊:
- 影响因子:
- 作者:
Teodora Kolarova;J. Lee Nelson;Hilary Gammill;Christina Lockwood;Raj Shree - 通讯作者:
Raj Shree
Microchimerism detection by human leucocyte antigen‐specific quantitative‐polymerase chain reaction analysis in recipients of allogeneic Epstein–Barr virus‐specific cytotoxic T lymphocytes
在同种异体 Epstein-Barr 病毒特异性细胞毒性 T 细胞淋巴受者中通过人白细胞抗原特异性定量聚合酶链反应分析检测微嵌合
- DOI:
10.1111/j.1365-2141.2005.05460.x - 发表时间:
2005 - 期刊:
- 影响因子:6.5
- 作者:
K. Lucas;J. Lee Nelson;Timothy D. Erickson;Qi Sun - 通讯作者:
Qi Sun
J. Lee Nelson的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('J. Lee Nelson', 18)}}的其他基金
Transgenerational Microchimerism in Pregnancy Loss
妊娠失败中的跨代微嵌合现象
- 批准号:
7306029 - 财政年份:2007
- 资助金额:
$ 20.76万 - 项目类别:
Transgenerational Microchimerism in Pregnancy Loss
妊娠失败中的跨代微嵌合现象
- 批准号:
7484075 - 财政年份:2007
- 资助金额:
$ 20.76万 - 项目类别:
HLA Alleles, Self-Peptides and Microbial Mimicry in SSc
SSc 中的 HLA 等位基因、自肽和微生物拟态
- 批准号:
6407027 - 财政年份:2001
- 资助金额:
$ 20.76万 - 项目类别:
HLA Alleles, Self-Peptides and Microbial Mimicry in SSc
SSc 中的 HLA 等位基因、自肽和微生物拟态
- 批准号:
6607038 - 财政年份:2001
- 资助金额:
$ 20.76万 - 项目类别:
HLA Alleles, Self-Peptides and Microbial Mimicry in SSc
SSc 中的 HLA 等位基因、自肽和微生物拟态
- 批准号:
6760840 - 财政年份:2001
- 资助金额:
$ 20.76万 - 项目类别:
相似海外基金
Unraveling Adverse Effects of Checkpoint Inhibitors Using iPSC-derived Cardiac Organoids
使用 iPSC 衍生的心脏类器官揭示检查点抑制剂的副作用
- 批准号:
10591918 - 财政年份:2023
- 资助金额:
$ 20.76万 - 项目类别:
Optimization of mRNA-LNP vaccine for attenuating adverse effects and analysis of mechanism behind adverse effects
mRNA-LNP疫苗减轻不良反应的优化及不良反应机制分析
- 批准号:
23K15383 - 财政年份:2023
- 资助金额:
$ 20.76万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Elucidation of adverse effects of combined exposure to low-dose chemicals in the living environment on allergic diseases and attempts to reduce allergy
阐明生活环境中低剂量化学品联合暴露对过敏性疾病的不良影响并尝试减少过敏
- 批准号:
23H03556 - 财政年份:2023
- 资助金额:
$ 20.76万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Green tea-based nano-enhancer as an adjuvant for amplified efficacy and reduced adverse effects in anti-angiogenic drug treatments
基于绿茶的纳米增强剂作为抗血管生成药物治疗中增强疗效并减少不良反应的佐剂
- 批准号:
23K17212 - 财政年份:2023
- 资助金额:
$ 20.76万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Effects of Tobacco Heating System on the male reproductive function and towards to the reduce of the adverse effects.
烟草加热系统对男性生殖功能的影响以及减少不利影响。
- 批准号:
22H03519 - 财政年份:2022
- 资助金额:
$ 20.76万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Mitigating the Adverse Effects of Ultrafines in Pressure Filtration of Oil Sands Tailings
减轻油砂尾矿压力过滤中超细粉的不利影响
- 批准号:
563657-2021 - 财政年份:2022
- 资助金额:
$ 20.76万 - 项目类别:
Alliance Grants
1/4-Deciphering Mechanisms of ECT Outcomes and Adverse Effects (DECODE)
1/4-破译ECT结果和不良反应的机制(DECODE)
- 批准号:
10521849 - 财政年份:2022
- 资助金额:
$ 20.76万 - 项目类别:
4/4-Deciphering Mechanisms of ECT Outcomes and Adverse Effects (DECODE)
4/4-破译ECT结果和不良反应的机制(DECODE)
- 批准号:
10671022 - 财政年份:2022
- 资助金额:
$ 20.76万 - 项目类别:
2/4 Deciphering Mechanisms of ECT Outcomes and Adverse Effects (DECODE)
2/4 ECT 结果和不良反应的破译机制(DECODE)
- 批准号:
10670918 - 财政年份:2022
- 资助金额:
$ 20.76万 - 项目类别:
Adverse Effects of Using Laser Diagnostics in High-Speed Compressible Flows
在高速可压缩流中使用激光诊断的不利影响
- 批准号:
RGPIN-2018-04753 - 财政年份:2022
- 资助金额:
$ 20.76万 - 项目类别:
Discovery Grants Program - Individual