High Frequency Oscillation as a Biomarker in Childhood Epilepsy

高频振荡作为儿童癫痫的生物标志物

• 批准号: 8484238
• 负责人: JOYCE Y WU
• 金额: $ 33.69万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-15 至 2018-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8484238
• 关键词: Animal Model; Animals; Anticonvulsants; Antiepileptic Agents; Area; Autistic Disorder; Biological Markers; Blinded; Child; Childhood; Clinic; Clinical Trials; Data; Decision Making; Detection; Developmental Delay Disorders; Disease; Elderly; Electrocorticogram; Electroencephalography; Epilepsy; Epileptogenesis; Etiology; Excision; Freedom; Future; Genetic; Goals; High Frequency Oscillation; Human; Infant; Investigation; Lead; Lesion; Life; Lobar; Medical; Microelectrodes; Molecular; Monitor; Neurotransmitters; Operating Rooms; Operative Surgical Procedures; Partial Epilepsies; Pathologic; Perinatal anoxic ischemic brain injury; Postoperative Period; Process; Reading; Refractory; Reporting; Research; Research Infrastructure; Resected; Risk; Role; Scalp structure; Seizures; Slice; Specimen; Synapses; Temporal Lobe; Therapeutic Intervention; TimeLine; Traumatic Brain Injury; Tuberous sclerosis protein complex; age group; base; drug mechanism; gamma-Aminobutyric Acid; high risk; insight; medical specialties; neocortical; neonatal hypoxic-ischemic brain injury; neonate; prospective; public health relevance

DESCRIPTION (provided by applicant): The goal of this proposal is a two-pronged approach to establish interictal high frequency oscillation (HFO) as a spatially localizing biomarker of the epileptogenic zone and as a temporally predictive biomarker of the epileptogenic process in childhood epilepsy. Epilepsy is a common group of disorders in children, a significant portion of whom will continue to have debilitating weekly or daily seizures despite new anticonvulsants and despite surgical resection of epileptogenic cortex. Why seizures continue unabated despite the best current medical and surgical therapy is unclear. Taking advantage of the already existing infrastructure that evaluates children for epilepsy and epilepsy surgery at UCLA, this proposal seeks to establish HFO as a spatially localizing biomarker of the epileptogenic zone (Hypothesis 1). Similarly, with three specialty clinics that follow 3 groups of high-risk pre- epileptic children, the proposal also aims to establish HFO as a temporally predictive marker of the epileptogenic process (Hypothesis 2) of who may go on to have epilepsy, with prospective serial video-EEGs. The results from this proposal will naturally lead to the next set of questions and research aims: 1) to incorporate HFO localization data in surgical decision-making in a clinical trial; 2) to further study the cellular and molecular mechanisms underlying HFO in resected cortical specimens to better understand epileptogenesis and possible antiepileptic drug mechanisms; 3) to enable potential therapeutic intervention in high-risk children, before seizure onset. Studies to help answer these questions are some of the long-term plans.

描述（由申请人提供）：该提案的目标是采用双管齐下的方法，建立发作间期高频振荡（HFO）作为该疾病的空间定位生物标志物。 癫痫发生区并作为儿童癫痫发生过程的时间预测生物标志物。 癫痫是儿童中常见的一组疾病，尽管使用了新的抗惊厥药物并且手术切除了致癫痫皮层，但其中很大一部分儿童仍会每周或每天癫痫发作，使人衰弱。尽管采用了目前最好的药物和手术治疗，但为什么癫痫发作仍然有增无减尚不清楚。该提案利用加州大学洛杉矶分校评估儿童癫痫和癫痫手术的现有基础设施，旨在将 HFO 建立为癫痫发生区的空间定位生物标志物（假设 1）。同样，通过三个专科诊所追踪 3 组高危癫痫前期儿童，该提案还旨在通过前瞻性连续视频脑电图将 HFO 建立为可能继续患癫痫的癫痫发生过程（假设 2）的时间预测标记。 这个提案的结果自然会引出下一组问题 研究目标：1）将HFO定位数据纳入临床试验的手术决策中； 2）进一步研究皮层切除标本中HFO的细胞和分子机制，以更好地了解癫痫发生和可能的抗癫痫药物机制； 3）在癫痫发作前对高危儿童进行潜在的治疗干预。帮助回答这些问题的研究是一些长期计划。