The impact of IL-4 on the CD8 T cell response to pathogens

IL-4对CD8 T细胞对病原体反应的影响

• 批准号: 8424945
• 负责人: STEPHEN C JAMESON
• 金额: $ 19万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-02-15 至 2015-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8424945
• 关键词: Address; Allergic; Antigens; Automobile Driving; Bacteria; Biological Models; CD4 Positive T Lymphocytes; CD8B1 gene; Cells; Cytokine Signaling; Data; Development; Disease; Health; Human; Immune response; Immunity; Infection; Infection Control; Interferons; Interleukin-13; Interleukin-2; Interleukin-4; Lead; Listeria; Listeria monocytogenes; Maintenance; Malaria; Mediating; Memory; Mus; Parasites; Phenotype; Plasmodium; Play; Production; Proteins; Publishing; Resistance; Resolution; Role; Serum Proteins; Signal Transduction; T cell response; T-Cell Proliferation; T-Lymphocyte; Testing; Vaccines; Virus; Work; base; clinically relevant; cytokine; cytokine therapy; improved; innovation; interest; interleukin-13 receptor; novel; pathogen; prevent; receptor; response

DESCRIPTION (provided by applicant): The cytokine IL-4 is well studied for its role in driving allergic/asthmatic CD4 T cell responses: However its impact on CD8 T cells is much less clear. Building on published and preliminary data, we propose that IL-4 plays a critical and unexpected role in supporting the CD8 T cell response to pathogens. These findings will be investigated further to define the exact role of IL-4 responsiveness in the CD8 T cell response, and additional work will test the novel concept that IL-4 cytokine therapy could be used to enhance CD8 T cell protective immunity against malarial parasites.

描述（由申请人提供）：细胞因子IL-4在驱动过敏/哮喘CD 4 T细胞应答中的作用已得到充分研究：然而，其对CD 8 T细胞的影响尚不清楚。基于已发表的和初步的数据，我们提出IL-4在支持CD 8 T细胞对病原体的应答中起着关键和意想不到的作用。这些发现将进一步研究，以确定IL-4反应性在CD 8 T细胞反应中的确切作用，另外的工作将测试IL-4细胞因子治疗可用于增强CD 8 T细胞对疟疾寄生虫的保护性免疫的新概念。