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The impact of IL-4 on the CD8 T cell response to pathogens

The impact of IL-4 on the CD8 T cell response to pathogens
IL-4对CD8 T细胞对病原体反应的影响
批准号：
8424945
负责人：
STEPHEN C JAMESON
金额：
$19.0万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
项目状态：
已结题
起止时间：
2012-02-15 至 2015-01-31
来源：
https://reporter.nih.gov/project-details/8424945
关键词：
AddressAllergicAntigensAutomobile DrivingBacteriaBiological ModelsCD4 Positive T LymphocytesCD8B1 geneCellsCytokine SignalingDataDevelopmentDiseaseHealthHumanImmune responseImmunityInfectionInfection ControlInterferonsInterleukin-13Interleukin-2Interleukin-4LeadListeriaListeria monocytogenesMaintenanceMalariaMediatingMemoryMusParasitesPhenotypePlasmodiumPlayProductionProteinsPublishingResistanceResolutionRoleSerum ProteinsSignal TransductionT cell responseT-Cell ProliferationT-LymphocyteTestingVaccinesVirusWorkbaseclinically relevantcytokinecytokine therapyimprovedinnovationinterestinterleukin-13 receptornovelpathogenpreventreceptorresponse

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中文摘要
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英文摘要
DESCRIPTION (provided by applicant): The cytokine IL-4 is well studied for its role in driving allergic/asthmatic CD4 T cell responses: However its impact on CD8 T cells is much less clear. Building on published and preliminary data, we propose that IL-4 plays a critical and unexpected role in supporting the CD8 T cell response to pathogens. These findings will be investigated further to define the exact role of IL-4 responsiveness in the CD8 T cell response, and additional work will test the novel concept that IL-4 cytokine therapy could be used to enhance CD8 T cell protective immunity against malarial parasites.
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Regulation of T cell responses by P2RX7
  • 批准号：
    10393494
  • 项目类别：
  • 资助金额：
    $55.07万
  • 财政年份：
    2019
  • 负责人：
    STEPHEN C JAMESON
  • 依托单位：
    UNIVERSITY OF MINNESOTA
Regulation of T cell responses by P2RX7
  • 批准号：
    10605308
  • 项目类别：
  • 资助金额：
    $55.07万
  • 财政年份：
    2019
  • 负责人：
    STEPHEN C JAMESON
  • 依托单位：
    UNIVERSITY OF MINNESOTA
The impact of IL-4 on the CD8 T cell response to pathogens
  • 批准号：
    8293998
  • 项目类别：
  • 资助金额：
    $22.8万
  • 财政年份：
    2012
  • 负责人：
    STEPHEN C JAMESON
  • 依托单位：
    UNIVERSITY OF MINNESOTA
Homeostatic Proliferation and Memory CD8 T Cells
  • 批准号：
    8660594
  • 项目类别：
  • 资助金额：
    $38.0万
  • 财政年份：
    2008
  • 负责人：
    STEPHEN C JAMESON
  • 依托单位：
    UNIVERSITY OF MINNESOTA
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