Homeostatic Proliferation and Memory CD8 T Cells

描述（由申请人提供）：记忆性CD 8 + T细胞提供针对先前遇到的抗原的必需特异性免疫，并且此类细胞的形成是疫苗接种的基本目标。我们的数据表明，免疫前的CD 8 T细胞群含有具有记忆样特性的细胞，我们称之为“稳态记忆”（HM）细胞。在本提案中，我们将测试这群T细胞如何有助于初级免疫反应。基于我们以前的数据，我们将实现两个目标。1)HM池在免疫应答期间如何早期响应病原体，以及这些细胞如何影响病原体生长或免疫应答期间可能出现的免疫病理学。我们还将扩展表明HM细胞在对抗原的反应方面与“幼稚”细胞有质的不同的数据。2)这一目标扩展了初步数据，表明细胞因子IL-4在控制CD 8 T细胞应答中起着意想不到的作用。我们将评估IL- 4在控制记忆性CD 8 T细胞维持中的功能，并建立在我们的初步数据基础上，通过确定IL-4介导其作用的阶段，表明IL-4支持CD 8对病原体的反应。

DESCRIPTION (provided by applicant): Memory CD8+ T cells provide essential specific immunity against previously encountered antigens, and formation of such cells is a fundamental goal of vaccination. Our data show that the pre-immune population of CD8 T cells contains cells with memory-like properties, which we call "Homeostatic memory" (HM) cells. In this proposal we will test how this population of T cells contributes to primary immune responses. Building on our previous data, we will conduct two aims. 1) how the HM pool responds to pathogens early during an immune response, and how these cells may affect pathogen growth or immunopathology that can arise during immune responses. We will also extend data suggesting HM cells differ qualitatively from "na¿ve" cells in their response to antigen. 2) This aim extends preliminary data suggesting the cytokine IL-4 plays an unexpected role in controlling CD8 T cell responses. We will assess the function of IL- 4 in controlling memory CD8 T cell maintenance, and build on our preliminary data showing that IL-4 supports the CD8 response to pathogens, by determining the stage at which IL-4 mediates its effects.