Molecular Biology in Burns and Trauma

描述(由申请者提供)：这个Ruth Kirschstein NRSA培训计划在其第14个年中建议在他们的普通住院医师计划的第二年或第三年期间主要接受外科医生和其他重症护理医学医生的培训，并让他们接受两年、三年甚至四年的炎症生物学指导研究，并由高生产率的基础科学导师专注于与炎症相关的主题。整个研究计划将侧重于掌握分子生物学、功能基因组学和基因调控，因为它广泛应用于炎症研究。需要三个培训职位。该计划将利用医学院在不断扩大的功能基因组学和分子生物学领域的独特优势，以及基础科学家和临床医生之间的合作，致力于培训未来的临床院士。精选学员将拥有 有机会在三到四年内完成研究生院的博士课程。分子生物学和炎症研究之间的接口将针对创伤、脓毒症综合征、缺血/再灌注损伤、血管损伤、伤口愈合延迟和烧伤创面。教员将从外科、医学、病理学、牙周病学、分子遗传学和微生物学系的受资助基础科学家中挑选，他们将担任受训人员的研究导师。来自外科、内科和病理科的临床导师将与学员和研究人员互动，以确保学员接触到炎症研究中具有临床重要性的问题。该计划的总体指导将由计划主任和执行委员会负责。该奖学金的候选人将在全国范围内和佛罗里达大学医学院招募。执行委员会的成功申请者将确定一名研究和临床导师，他将帮助制定正式的培训计划，并定期审查受训人员的进度。培训计划的大部分将在有经验的研究导师的实验室进行，但受训者也将被要求完成研究伦理方面的基本课程工作。 和统计方法，并将鼓励获得分子生物学的补充教学培训。此外，受训人员将参加新兴病原体研究所和遗传学研究所的基础科学研讨会，以及他们自己的基础科学系的研讨会，以及实验室研究会议。他们还将参加临床研讨会，包括外科和危重护理医学大查房和外科系学术研究会议。预计成功的毕业生将拥有足够的研究技能，以竞争炎症研究的过渡资金。

DESCRIPTION (provided by applicant): This Ruth Kirschstein NRSA training Program in its 14th year proposes to take primarily surgeons and other critical care medicine physicians during the second or third year of their general residency programs, and expose them to two, three and even four years of mentored research in inflammation biology with highly productive basic science mentors focused on inflammation-related topics. The overall research program will focus on mastery of molecular biology, functional genomics and gene regulation, as it applies broadly to inflammation research. Three training positions are requested. This program will take advantage of the unique strengths of the College of Medicine in the expanding field of functional genomics and molecular biology, as well as the collaborations between basic scientists and clinicians committed to the training of future clinical academicians. Select trainees will have the opportunity to complete a Ph.D. program in the Graduate School in three to four years. The interface between molecular biology and inflammation research will be targeted to trauma, sepsis syndromes, ischemia/reperfusion injury, vascular injury, delayed wound healing and the burn wound. The faculty will be drawn from funded basic scientists in the Surgery, Medicine, Pathology, Periodontology, and Molecular Genetics and Microbiology Departments, who will serve as research mentors to the trainees. Clinical mentors from the Surgery, Medicine and Pathology Departments will interact with the trainees and the research faculty to assure that the trainees are being exposed to clinically-important issues in inflammation research. Overall direction of the program will rest with the Program Director and the Executive Committee. Candidates for the fellowship will be recruited nationally and from the University of Florida College of Medicine. Successful applicants with the Executive Committee will identify a research and clinical mentor who will help formulate a formal training program and periodic review of the trainee's progress. The bulk of the training program will be in the laboratory of an experienced research mentor, but trainees will also be required to fulfill basic course work in research ethics and statistical methods, and will be encouraged to obtain supplemental didactic training in molecular biology. Furthermore, trainees are expected to participate in basic science seminars in the Emerging Pathogens Institute and Genetics Institute, and in their own basic science departments, as well as laboratory research meetings. They will also be expected to attend clinical seminars, including Surgery and Critical Care Medicine Grand Rounds and the Department of Surgery Academic Research Conference. It is anticipated that successful graduates will possess sufficient research skills to compete for transitional funding in inflammation research.