Mentoring researchers on drug abuse and HIV

指导药物滥用和艾滋病毒研究人员

• 批准号: 8730413
• 负责人: Chinazo Cunningham
• 金额: $ 18.58万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8730413
• 关键词: Abstinence; Address; Adherence; Agonist; Area; Award; Behavior; Blood Tests; Buprenorphine; CD4 Lymphocyte Count; Caring; Clinical Trials; Clinical Trials Design; Cocaine; Color; Communities; Complex; Control Groups; Data; Databases; Drug abuse; Drug usage; Drug user; Enrollment; Ensure; Epidemic; Feedback; Foundations; Funding; Goals; HIV; HIV Infections; HIV risk; Health; Health Services Accessibility; Healthcare; Highly Active Antiretroviral Therapy; Improve Access; Incentives; Individual; Intervention; Leadership; Life; Medical Records; Medical center; Medicine; Mentors; Mentorship; Methadone; Methods; Minority Groups; Neurocognitive; Opiate Addiction; Opiates; Opioid; Outcome; Oxycodone; Participant; Patients; Performance; Pharmaceutical Preparations; Population; Positioning Attribute; Public Health; Questionnaires; Randomized; Randomized Controlled Trials; Reading; Research; Research Infrastructure; Research Methodology; Research Personnel; Research Project Grants; Research Support; Risk; Risk Behaviors; Smoker; Smoking Cessation Intervention; Structure; Testing; Toxicology; Treatment outcome; United States National Institutes of Health; Urine; Viral Load result; Woman; base; career; cocaine use; comparative effectiveness; contingency management; effectiveness research; efficacy testing; improved; meetings; novel strategies; patient oriented research; pill; prescription opioid; primary outcome; programs; public health relevance; secondary outcome; skills; success; symposium; therapy adherence; voucher

DESCRIPTION (provided by applicant): Drug users with and at-risk for HIV continue to have poor access to health care and poor treatment outcomes. In addition, opioid addiction involving prescription opioids has skyrocketed. In this proposal for a mid-career investigator award, Dr. Chinazo Cunningham proposes to address the opioid epidemic and its intersection with HIV infection by: 1) becoming an internationally recognized leader in the field of drug abuse and HIV, expanding her research to include advanced research methods (comparative effectiveness research [CER] methods and complex clinical trials methods); 2) developing a standardized and structured mentorship approach to mentor junior investigators to conduct patient-oriented research related to drug abuse and/or HIV infection; and 3) becoming an effective leader in academic medicine, ensuring that the institutional infrastructure facilitates junior investigators obtaining skills necessary to become independent investigators. To achieve these goals, Dr. Cunningham will participate in courses and national conferences, have directed readings, and regularly meet with national leaders in related fields. Dr. Cunningham will particularly focus on mentoring women and racial/ethnic minorities-two groups who are under-represented in senior positions in academic medicine and NIH-funded research. Dr. Cunningham will utilize her existing research program as a foundation for which she will provide mentoring and expand her research skills to include CER and complex clinical trials methods. The aims of her research are to: 1) test the efficacy of a 16-week abstinence-reinforcing contingency management intervention on HIV viral load suppression among opioid-dependent HIV-infected individuals, using a randomized controlled trial design; and 2) examine mechanisms of achieving viral load suppression with the abstinence-reinforcing contingency management intervention. Dr. Cunningham's future research will include the establishment of a comprehensive "live" database of all opioid users within a large urban medical center. This database will be used to examine health outcomes associated with types of opioid use and to develop and test interventions focused on opioid use. Dr. Cunningham's long-term career objective is to improve access to care and health outcomes among drug-abusing populations with or at-risk for HIV infection by developing interventions that can reduce their disparities in health care and health.

描述（由申请人提供）：患有艾滋病毒或有感染艾滋病毒风险的吸毒者仍然难以获得医疗保健，且治疗结果不佳。此外，涉及处方阿片类药物的阿片类药物成瘾激增。在这项职业生涯中期研究员奖提案中，Chinazo Cunningham 博士提议通过以下方式解决阿片类药物流行及其与 HIV 感染的交叉问题：1) 成为药物滥用和 HIV 领域国际公认的领导者，将她的研究扩展到先进的研究方法（比较有效性研究 [CER] 方法和复杂的临床试验方法）； 2) 制定标准化和结构化的指导方法来指导初级研究人员开展与药物滥用和/或艾滋病毒感染相关的以患者为导向的研究； 3）成为学术医学领域的有效领导者，确保机构基础设施有利于初级研究者获得成为独立研究者所需的技能。为了实现这些目标，坎宁安博士将参加课程和全国会议，进行定向阅读，并定期与相关领域的国家领导人会面。坎宁安博士将特别关注指导女性和少数族裔，这两个群体在学术医学和美国国立卫生研究院资助的研究中担任高级职位的人数不足。 Cunningham 博士将利用她现有的研究项目作为基础，为其提供指导并扩展她的研究技能，以包括 CER 和复杂的临床试验方法。她的研究目的是：1）使用随机对照试验设计，测试为期 16 周的禁欲强化应急管理干预措施对阿片类药物依赖的 HIV 感染者中 HIV 病毒载量抑制的功效； 2）研究通过加强戒断的应急管理干预来实现病毒载量抑制的机制。坎宁安博士未来的研究将包括在大型城市医疗中心内建立所有阿片类药物使用者的综合“实时”数据库。该数据库将用于检查与阿片类药物使用类型相关的健康结果，并开发和测试针对阿片类药物使用的干预措施。 Cunningham 博士的长期职业目标是通过制定可减少医疗保健和健康方面差距的干预措施，改善感染艾滋病毒或有感染艾滋病毒风险的吸毒人群获得护理和健康结果的机会。