Mentoring researchers on drug abuse and HIV

指导药物滥用和艾滋病毒研究人员

• 批准号: 9240580
• 负责人: Chinazo Cunningham
• 金额: $ 4.85万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9240580
• 关键词: Abstinence; Address; Adherence; Agonist; Area; Award; Behavior; Blood Tests; Buprenorphine; CD4 Lymphocyte Count; Caring; Clinical Trials; Cocaine; Color; Communities; Complex; Control Groups; Data; Databases; Drug abuse; Drug usage; Drug user; Enrollment; Ensure; Epidemic; Feedback; Foundations; Funding; Goals; HIV; HIV Infections; HIV risk; Health; Health Services Accessibility; Healthcare; Highly Active Antiretroviral Therapy; Improve Access; Incentives; Individual; International; Intervention; Leadership; Medical Records; Medical center; Medicine; Mentors; Mentorship; Methadone; Methods; Motivation; Neurocognitive; Opiate Addiction; Opiates; Opioid; Outcome; Oxycodone; Participant; Patients; Performance; Pharmaceutical Preparations; Population; Positioning Attribute; Public Health; Questionnaires; Randomized; Randomized Controlled Trials; Reading; Research; Research Infrastructure; Research Methodology; Research Personnel; Research Project Grants; Research Support; Risk; Risk Behaviors; Smoker; Smoking Cessation Intervention; Standardization; Structure; Testing; Toxicology; Treatment outcome; United States National Institutes of Health; Urine; Viral Load result; Woman; base; career; cocaine use; comparative effectiveness; contingency management; effectiveness research; efficacy testing; ethnic minority population; health care availability; health disparity; improved; improved outcome; novel strategies; opioid use; patient oriented research; pill; prescription opioid; primary outcome; programs; public health relevance; racial and ethnic; secondary outcome; skills; success; symposium; therapy adherence; trial design; voucher

DESCRIPTION (provided by applicant): Drug users with and at-risk for HIV continue to have poor access to health care and poor treatment outcomes. In addition, opioid addiction involving prescription opioids has skyrocketed. In this proposal for a mid-career investigator award, Dr. Chinazo Cunningham proposes to address the opioid epidemic and its intersection with HIV infection by: 1) becoming an internationally recognized leader in the field of drug abuse and HIV, expanding her research to include advanced research methods (comparative effectiveness research [CER] methods and complex clinical trials methods); 2) developing a standardized and structured mentorship approach to mentor junior investigators to conduct patient-oriented research related to drug abuse and/or HIV infection; and 3) becoming an effective leader in academic medicine, ensuring that the institutional infrastructure facilitates junior investigators obtaining skills necessary to become independent investigators. To achieve these goals, Dr. Cunningham will participate in courses and national conferences, have directed readings, and regularly meet with national leaders in related fields. Dr. Cunningham will particularly focus on mentoring women and racial/ethnic minorities-two groups who are under-represented in senior positions in academic medicine and NIH-funded research. Dr. Cunningham will utilize her existing research program as a foundation for which she will provide mentoring and expand her research skills to include CER and complex clinical trials methods. The aims of her research are to: 1) test the efficacy of a 16-week abstinence-reinforcing contingency management intervention on HIV viral load suppression among opioid-dependent HIV-infected individuals, using a randomized controlled trial design; and 2) examine mechanisms of achieving viral load suppression with the abstinence-reinforcing contingency management intervention. Dr. Cunningham's future research will include the establishment of a comprehensive "live" database of all opioid users within a large urban medical center. This database will be used to examine health outcomes associated with types of opioid use and to develop and test interventions focused on opioid use. Dr. Cunningham's long-term career objective is to improve access to care and health outcomes among drug-abusing populations with or at-risk for HIV infection by developing interventions that can reduce their disparities in health care and health.

描述（由申请人提供）：感染艾滋病毒和有感染艾滋病毒风险的吸毒者仍然难以获得医疗保健，治疗效果不佳。此外，涉及处方阿片类药物的阿片类药物成瘾也在飙升。在这份职业中期研究者奖的提案中，Chinazo Cunningham博士建议通过以下方式解决阿片类药物流行及其与艾滋病毒感染的交叉问题：1）成为药物滥用和艾滋病毒领域的国际公认领导者，将她的研究扩展到包括先进的研究方法（比较有效性研究[CER]方法和复杂临床试验方法）; 2）制定一个标准化和结构化的指导方法，指导初级研究人员进行与药物滥用和/或艾滋病毒感染有关的以病人为导向的研究; 3）成为学术医学的有效领导者，确保机构基础设施有助于初级研究人员获得成为独立研究人员所需的技能。为了实现这些目标，坎宁安博士将参加课程和国家会议，指导阅读，并定期与相关领域的国家领导人会面。坎宁安博士将特别关注指导妇女和种族/少数民族-这两个群体在学术医学和NIH资助的研究的高级职位中代表性不足。坎宁安博士将利用她现有的研究计划作为基础，她将提供指导，并扩大她的研究技能，包括CER和复杂的临床试验方法。她的研究的目的是：1）使用随机对照试验设计，测试16周禁欲强化应急管理干预对阿片类药物依赖的HIV感染者中HIV病毒载量抑制的有效性;和2）检查通过禁欲强化应急管理干预实现病毒载量抑制的机制。坎宁安博士未来的研究将包括在大型城市医疗中心建立一个包含所有阿片类药物使用者的全面“实时”数据库。该数据库将用于检查与类阿片使用类型相关的健康结果，并制定和测试以类阿片使用为重点的干预措施。坎宁安博士的长期职业目标是通过制定干预措施，减少他们在医疗保健和健康方面的差距，改善有艾滋病毒感染或有艾滋病毒感染风险的吸毒人群获得护理和健康成果的机会。