Rochester Epidemiology Project

描述（由申请人提供）：本续期申请要求支持罗切斯特流行病学项目（REP），该项目自1966年以来一直支持明尼苏达州奥姆斯特德县居民的病历联系系统。这种独特的研究基础设施记载了从20世纪初到现在为社区居民提供的医疗保健，并支持了几乎每一项研究设计和美国发生的大多数疾病实体的基于人群的流行病学调查。REP支持了马约医学中心，奥姆斯特德医学中心和其他学术机构的大量研究人员的工作，并允许对具有重大社会影响的疾病进行有效的校外资助研究。REP目前支持40个政府资助的赠款，自42年前首次资助以来，同行评审文献中已发表了1，800多篇手稿，其中包括自2005年我们最后一次竞争更新以来的214篇。这个广泛的数据存储库从一个地理定义的人口在这个国家几乎是无与伦比的，这是至关重要的，这一重要的研究基础设施被保存和扩展到未来。这项赠款的每一个周期都提供了一个机会，不仅可以维持核心的医疗记录联系功能，而且可以提高其效用。在这一更新申请中，我们建议更新REP医疗记录链接系统至2015年（目标1）;通过链接医疗服务和程序及其相应费用、药物处方和免疫接种的额外数据来加强REP基础设施（目标2）;并将REP基础设施扩展到居住在明尼苏达州东南部8个县地区的更多人口（奥姆斯特德加上周围的道奇、菲尔莫尔、沃巴沙、莫尔、古德韦、威诺纳和休斯顿县;目标3）。这些新目标建立在我们当前和以前项目周期的成就基础上，包括更及时的数据收集，对历史纸质医疗记录进行大规模扫描和诊断索引，增加新的信息来源和分析方法，开发正在进行的人口普查枚举，以及开发工具以增加访问的便利性，同时提供更大的数据安全性。因此，本次更新申请中提出的目标将为越来越多的临床研究者、流行病学家、统计学家和基础科学家组成的多学科团队提供更高的数据可用性，这些团队正在解决重大的公共卫生问题。最终目标是继续支持以人群为基础的疾病病因学研究，预防性干预措施，改善医疗实践和改善人群健康，如NIH路线图所述。

DESCRIPTION (provided by applicant): This renewal application requests support for the Rochester Epidemiology Project (REP) that has supported the medical records-linkage system for residents of Olmsted County, MN, since 1966. This unique research infrastructure chronicles the medical care delivered to community residents from the early 1900s to the present and has supported population-based epidemiologic investigations of virtually every study design and of most disease entities occurring in the U.S. The REP has supported the work of a large number of investigators at Mayo Medical Center, Olmsted Medical Center, and other academic institutions, and has permitted the efficient conduct of extramurally- funded studies of diseases with substantial societal impact. The REP currently supports 40 government-funded grants, and since its initial funding 42 years ago, more than 1,800 manuscripts have been published in the peer-reviewed literature, including 214 since our last competing renewal in 2005. This extensive data repository from a geographically-defined population is virtually unparalleled in this country, and it is essential that this important research infrastructure be preserved and extended into the future. Each cycle of this grant has presented an opportunity to not only maintain the core medical records-linkage function, but also to enhance its utility. In this renewal application, we propose to update the REP medical records-linkage system through 2015 (Aim 1); to enhance the REP infrastructure by linking additional data on medical services and procedures and their corresponding costs, drug prescriptions, and immunizations (Aim 2); and to expand the REP infrastructure to the larger population of individuals residing in the 8-county region of southeastern Minnesota (Olmsted plus surrounding Dodge, Fillmore, Wabasha, Mower, Goodhue, Winona, and Houston counties; Aim 3). These new aims build on our accomplishments from the current and previous project cycles that include more timely data collection, massive scanning and diagnostic indexing of historical paper medical records, addition of new sources of information and analytic methods, development of an ongoing census enumeration, and development of tools to increase ease of access while providing greater data security. Thus, the aims proposed in this renewal application will provide increased data availability for the growing number of multidisciplinary teams of clinical investigators, epidemiologists, statisticians, and basic scientists who are addressing significant public health questions. The ultimate goal is to continue to support population-based research of disease etiology, preventive interventions, improved medical practice, and better health for the population, as outlined in the NIH Roadmap.