DETECTION AND MODELS OF TOXICANT EXPOSURE

了解我们环境中危险化学品的细胞和分子机制是一个关键的国家目标。1980年建立的综合环境响应、补偿和责任法案(CERCLA)是为了了解与暴露于超级基金场地危险废物相关的公共健康风险。因此，更好地了解接触途径和人类接触来自Superfund和其他危险废物场地的未受控制的危险废物所造成的健康后果是高度优先事项。加州大学圣地亚哥分校(UCSD)超级基金研究计划(SRP)中心的目标是对毒物暴露的生物影响的分子和遗传基础产生新的观点，从而产生衡量健康风险和评估健康影响的新方法；创新的毒性检测和监测系统；以及新的生物修复模式。我们的发现表明，化学暴露会导致基因表达模式的改变，这些模式由潜在的信号转导途径控制和调节。调查人员将检验这一假设，即“超级基金所在地的化学物质对生物反应的改变可以被用来开发检测和生物修复化学毒物的模型”。加州大学圣迭戈分校SRP中心开发了一个多学科的努力，包括六个生物医学研究项目、两个非生物医学研究项目、两个研究支持核心以及研究翻译和社区参与核心。这项研究将得到博士培训项目的部分支持。我们靠近人口稠密的美墨边境的沿海环境所特有的环境问题造成了涉及水中污染物的问题，这些问题具有特别重要的意义。通过我们的研究翻译和社区参与核心，与当地行业和社区团体建立了合作伙伴关系，将我们正在开发的技术用作评估暴露水平和预测健康风险的应用生物工具。来自加州大学圣迭戈分校十个部门、有组织的研究单位和中心以及两个外部组织的免费专业人员参与了这一项目。我们的共同努力有望为导致环境疾病的分子机制提供新的见解，并提高我们对暴露于超级基金现场污染物的后果的理解。

Understanding the cellular and molecular mechanisms of hazardous chemicals in our environment is a critical national objective. Comprehensive Environmental Response, Compensation and Liability Act of 1980 (CERCLA) was established to gain knowledge on the public health risks associated with exposure to Superfund site hazardous waste. Thus, a greater understanding of the exposure pathways and the health consequences resulting from human exposure to uncontrolled hazardous waste from Superfund and other hazardous waste sites are high priorities. The University of Californian at San Diego (UCSD) Superfund Research Program (SRP) Center's objective is to generate new perspectives on the molecular and genetic basis of the biological effects of toxicant exposure, leading to new methodologies for gauging health risks and assessing health effects; innovative detection and monitoring systems for toxicity; and novel models for bioremediation. Our findings have shown that chemical exposure leads to alterations in patterns of gene expression which are controlled and regulated by underlying signal transduction pathways. The investigators will test the hypothesis that "Alterations in biological response by Superfund site chemicals can be exploited to develop models for the detection and bioremediation of chemical toxicants". The UCSD SRP Center has developed a multidisciplinary effort consisting of six biomedical research projects, two non-biomedical research projects, two research support cores and Research Translation and Community Engagement cores. The research will be supported in part by a Ph.D. training program. The environmental problems unique to our coastal environment proximate to the populous U.S.-Mexico border create issues involving water born pollutants that are of special relevance. Through our Research Translation and Community Engagement cores, partnerships have been formed with local industry and community groups to utilize our developing technologies as applied biological tools for assessment of exposure levels and to predict health risk. Investigators with complimentary expertise from ten UCSD Departments, Organized Research Units and Centers are participating in this project, as well as two outside organizations. Our combined efforts are anticipated to provide new insights into the molecular mechanisms that lead to environmental illness, and improve our understanding of the consequences of exposure to Superfund site contaminants.