Core Center for Musculoskeletal Biology and Medicine

肌肉骨骼生物学和医学核心中心

• 批准号: 8692027
• 负责人: LINDA J SANDELL
• 金额: $ 55.83万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-11 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8692027
• 关键词: Animal Experimentation; Animal Model; Award; Biological Factors; Biology; Cells; Collaborations; Degenerative polyarthritis; Disease; Five-Year Plans; Fostering; Funding; Grant; Histology; Image; Intervertebral disc structure; Leadership; Malignant Neoplasms; Mechanics; Medicine; Mentors; Metabolic Diseases; Metastatic Neoplasm to the Bone; Monitor; Muscle; Muscular Dystrophies; Musculoskeletal; Musculoskeletal Diseases; Neoplasm Metastasis; Osteoporosis; Pain; Patients; Population; Publications; Regenerative Medicine; Reporter; Research; Research Personnel; Research Technics; Science; Series; Services; Stem cells; Structure; Techniques; Technology; Tendon Injuries; Tendon structure; Testing; Tissues; Training; Training and Education; Translations; United States National Institutes of Health; Zebrafish; base; bone healing; bone strength; cartilage repair; interdisciplinary approach; interest; lost work time; member; morphometry; programs; public health relevance; ranpirnase; scoliosis; skeletal; stem; symposium

DESCRIPTION (provided by applicant): Over the past four years with the opportunity provided by the P30 CCMBM grant, our loosely organized set of musculoskeletal labs has developed into a well-respected Musculoskeletal Research Center with 75 members from 22 Departments, over 250 publications (158 in Reporter), a new facility with 12 musculoskeletal labs co-localized with the Administration and Research Cores, an active and productive Pilot and Feasibility Program, a popular Musculoskeletal Seminar Series and well-attended Annual Symposia. Our fields of interest have covered a wide variety of common musculoskeletal disorders from osteoporosis to osteoarthritis to tendon injuries to cancer. We now have $59 million in funding with $35 million from the NIH, and were recently awarded a T32 Training grant in Skeletal Metabolic Diseases. During the next five years, we plan to grow our Center to include a wider range of research interests stemming from our larger and more diverse research base, such as cancer metastasis to bone, scoliosis and intervertebral disc disease, tendon to bone healing, cartilage repair and stem cells in regenerative medicine. Our enrichment program will be expanded to include mentoring activities and training and education in specialized research techniques. The CCMBM enables the offering of many new services that will help drive the science of the research base, such as an expansion of the animal models to include zebrafish, isolation of specific populations of cells using histology and new non-invasive techniques to monitor tissue quality. Our Research Cores are: Core B: Musculoskeletal Structure and Strength, Core C: Histology and Morphometry, and Core D: Animal Models. With the help of the ICTS, we are very excited to include a new emphasis on translation of our animal research to the patient. The CCMBM will continue to provide leadership in promoting quality research, foster collaborations and interdisciplinary approaches, expand the ranks of the research base and help drive the science of musculoskeletal investigators by providing increasingly sophisticated and powerful technologies through our research cores.

描述（申请人提供）：在过去的四年里，借助P30 CCMBM资助提供的机会，我们组织松散的肌肉骨骼实验室已发展成为一个备受尊敬的肌肉骨骼研究中心，拥有来自22个部门的75名成员，发表了250多种出版物（158在记者），一个新的设施与12个肌肉骨骼实验室共同定位与行政和研究核心，一个积极和富有成效的试点和可行性计划，一个受欢迎的肌肉骨骼研讨会系列和出席人数众多的年度研讨会。我们感兴趣的领域已经涵盖了各种常见的肌肉骨骼疾病，从骨质疏松症到骨关节炎，肌腱损伤到癌症。我们现在有5900万美元的资金，其中3500万美元来自美国国立卫生研究院，最近还获得了Skeleton代谢疾病的T32培训补助金。在接下来的五年里，我们计划发展我们的中心，以包括更广泛的研究兴趣来自我们更大和更多样化的研究基地，如癌症转移到骨，脊柱侧凸和椎间盘疾病，肌腱骨愈合，软骨修复和干细胞在再生医学。 我们的丰富计划将扩大到包括指导活动和培训和教育的专业研究技术。CCMBM能够提供许多新的服务，这些服务将有助于推动研究基地的科学发展，例如将动物模型扩展到包括斑马鱼，使用组织学和新的非侵入性技术分离特定的细胞群来监测组织质量。 我们的研究核心是：核心B：肌肉骨骼结构和力量，核心C：组织学和形态学，核心D：动物模型。在ICTS的帮助下，我们非常高兴能够将我们的动物研究翻译成患者。CCMBM将继续在促进高质量研究方面发挥领导作用，促进合作和跨学科方法，扩大研究基地的队伍，并通过我们的研究核心提供日益复杂和强大的技术，帮助推动肌肉骨骼研究人员的科学发展。