Core Center for Musculoskeletal Biology and Medicine

肌肉骨骼生物学和医学核心中心

• 批准号: 8692027
• 负责人: LINDA J SANDELL
• 金额: $ 55.83万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-11 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8692027
• 关键词: Animal Experimentation; Animal Model; Award; Biological Factors; Biology; Cells; Collaborations; Degenerative polyarthritis; Disease; Five-Year Plans; Fostering; Funding; Grant; Histology; Image; Intervertebral disc structure; Leadership; Malignant Neoplasms; Mechanics; Medicine; Mentors; Metabolic Diseases; Metastatic Neoplasm to the Bone; Monitor; Muscle; Muscular Dystrophies; Musculoskeletal; Musculoskeletal Diseases; Neoplasm Metastasis; Osteoporosis; Pain; Patients; Population; Publications; Regenerative Medicine; Reporter; Research; Research Personnel; Research Technics; Science; Series; Services; Stem cells; Structure; Techniques; Technology; Tendon Injuries; Tendon structure; Testing; Tissues; Training; Training and Education; Translations; United States National Institutes of Health; Zebrafish; base; bone healing; bone strength; cartilage repair; interdisciplinary approach; interest; lost work time; member; morphometry; programs; public health relevance; ranpirnase; scoliosis; skeletal; stem; symposium

DESCRIPTION (provided by applicant): Over the past four years with the opportunity provided by the P30 CCMBM grant, our loosely organized set of musculoskeletal labs has developed into a well-respected Musculoskeletal Research Center with 75 members from 22 Departments, over 250 publications (158 in Reporter), a new facility with 12 musculoskeletal labs co-localized with the Administration and Research Cores, an active and productive Pilot and Feasibility Program, a popular Musculoskeletal Seminar Series and well-attended Annual Symposia. Our fields of interest have covered a wide variety of common musculoskeletal disorders from osteoporosis to osteoarthritis to tendon injuries to cancer. We now have $59 million in funding with $35 million from the NIH, and were recently awarded a T32 Training grant in Skeletal Metabolic Diseases. During the next five years, we plan to grow our Center to include a wider range of research interests stemming from our larger and more diverse research base, such as cancer metastasis to bone, scoliosis and intervertebral disc disease, tendon to bone healing, cartilage repair and stem cells in regenerative medicine. Our enrichment program will be expanded to include mentoring activities and training and education in specialized research techniques. The CCMBM enables the offering of many new services that will help drive the science of the research base, such as an expansion of the animal models to include zebrafish, isolation of specific populations of cells using histology and new non-invasive techniques to monitor tissue quality. Our Research Cores are: Core B: Musculoskeletal Structure and Strength, Core C: Histology and Morphometry, and Core D: Animal Models. With the help of the ICTS, we are very excited to include a new emphasis on translation of our animal research to the patient. The CCMBM will continue to provide leadership in promoting quality research, foster collaborations and interdisciplinary approaches, expand the ranks of the research base and help drive the science of musculoskeletal investigators by providing increasingly sophisticated and powerful technologies through our research cores.

描述（由申请人提供）：在过去的四年中，P30 CCMBM Grant提供的机会，我们宽松组织的一组肌肉骨骼实验室已发展为一个备受尊敬的肌肉骨骼研究中心，有75名成员，来自22个部门的75名成员，有250个部门，超过250个出版物（158个记者），一个新的努力，是一个新的努力，并有效地进行了努力，并进行了研究。飞行员和可行性计划，这是一个流行的肌肉骨骼研讨会系列和受人欢迎的年度研讨会。我们感兴趣的领域涵盖了从骨质疏松症到骨关节炎再到肌腱损伤到癌症的各种常见肌肉骨骼疾病。现在，我们从NIH获得了3500万美元的资金，并获得了5,900万美元的资金，最近获得了骨骼代谢疾病的T32培训补助金。在接下来的五年中，我们计划发展中心，包括源于我们更大，更多样化的研究基础的广泛研究兴趣，例如癌症转移到骨骼，脊柱侧弯和椎间盘疾病，肌腱对骨骼愈合，软骨修复和再生药物中的干细胞。 我们的丰富计划将扩展到包括指导活动以及专业研究技术的培训和教育。 CCMBM可以提供许多新服务，这些服务将有助于推动研究基础的科学，例如，动物模型的扩展以包括斑马鱼，使用组织学和新的非侵入性技术来监测组织质量的细胞群体分离。 我们的研究核心是：核心B：肌肉骨骼结构和力量，核心C：组织学和形态计量学以及核心D：动物模型。在ICT的帮助下，我们很高兴将我们的动物研究转化为患者的新重点。 CCMBM将继续为促进优质研究，培养合作和跨学科方法，扩大研究基础的排名，并通过我们的研究核心提供越来越复杂且强大的技术来推动肌肉骨骼研究人员的科学。