Core Center for Musculoskeletal Biology and Medicine

肌肉骨骼生物学和医学核心中心

• 批准号: 8692027
• 负责人: LINDA J SANDELL
• 金额: $ 55.83万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-11 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8692027
• 关键词: Animal Experimentation; Animal Model; Award; Biological Factors; Biology; Cells; Collaborations; Degenerative polyarthritis; Disease; Five-Year Plans; Fostering; Funding; Grant; Histology; Image; Intervertebral disc structure; Leadership; Malignant Neoplasms; Mechanics; Medicine; Mentors; Metabolic Diseases; Metastatic Neoplasm to the Bone; Monitor; Muscle; Muscular Dystrophies; Musculoskeletal; Musculoskeletal Diseases; Neoplasm Metastasis; Osteoporosis; Pain; Patients; Population; Publications; Regenerative Medicine; Reporter; Research; Research Personnel; Research Technics; Science; Series; Services; Stem cells; Structure; Techniques; Technology; Tendon Injuries; Tendon structure; Testing; Tissues; Training; Training and Education; Translations; United States National Institutes of Health; Zebrafish; base; bone healing; bone strength; cartilage repair; interdisciplinary approach; interest; lost work time; member; morphometry; programs; public health relevance; ranpirnase; scoliosis; skeletal; stem; symposium

DESCRIPTION (provided by applicant): Over the past four years with the opportunity provided by the P30 CCMBM grant, our loosely organized set of musculoskeletal labs has developed into a well-respected Musculoskeletal Research Center with 75 members from 22 Departments, over 250 publications (158 in Reporter), a new facility with 12 musculoskeletal labs co-localized with the Administration and Research Cores, an active and productive Pilot and Feasibility Program, a popular Musculoskeletal Seminar Series and well-attended Annual Symposia. Our fields of interest have covered a wide variety of common musculoskeletal disorders from osteoporosis to osteoarthritis to tendon injuries to cancer. We now have $59 million in funding with $35 million from the NIH, and were recently awarded a T32 Training grant in Skeletal Metabolic Diseases. During the next five years, we plan to grow our Center to include a wider range of research interests stemming from our larger and more diverse research base, such as cancer metastasis to bone, scoliosis and intervertebral disc disease, tendon to bone healing, cartilage repair and stem cells in regenerative medicine. Our enrichment program will be expanded to include mentoring activities and training and education in specialized research techniques. The CCMBM enables the offering of many new services that will help drive the science of the research base, such as an expansion of the animal models to include zebrafish, isolation of specific populations of cells using histology and new non-invasive techniques to monitor tissue quality. Our Research Cores are: Core B: Musculoskeletal Structure and Strength, Core C: Histology and Morphometry, and Core D: Animal Models. With the help of the ICTS, we are very excited to include a new emphasis on translation of our animal research to the patient. The CCMBM will continue to provide leadership in promoting quality research, foster collaborations and interdisciplinary approaches, expand the ranks of the research base and help drive the science of musculoskeletal investigators by providing increasingly sophisticated and powerful technologies through our research cores.

描述（由申请人提供）：在过去的四年中，在P30 CCMBM拨款的支持下，我们组织松散的肌肉骨骼实验室已经发展成为一个受人尊敬的肌肉骨骼研究中心，拥有来自22个部门的75名成员，超过250份出版物（其中158份在Reporter上），一个拥有12个肌肉骨骼实验室的新设施，与行政和研究中心共同定位，一个积极和富有成效的试点和可行性计划。一个受欢迎的肌肉骨骼研讨会系列和参加人数众多的年度专题讨论会。我们感兴趣的领域涵盖了各种常见的肌肉骨骼疾病，从骨质疏松症到骨关节炎，从肌腱损伤到癌症。我们现在有5900万美元的资金来自美国国立卫生研究院的3500万美元，最近还获得了骨骼代谢疾病的T32培训补助金。在接下来的五年里，我们计划发展我们的中心，包括更广泛的研究兴趣，如癌症转移到骨骼，脊柱侧弯和椎间盘疾病，肌腱到骨愈合，软骨修复和再生医学中的干细胞。我们的充实计划将扩大到包括指导活动和专门研究技术的培训和教育。CCMBM能够提供许多有助于推动研究基地科学发展的新服务，例如将动物模型扩展到包括斑马鱼，使用组织学分离特定群体的细胞和新的非侵入性技术来监测组织质量。我们的研究核心是：核心B：肌肉骨骼结构和力量，核心C：组织学和形态计量学，核心D：动物模型。在信息通信技术的帮助下，我们非常兴奋地将我们的动物研究转化为患者。CCMBM将继续发挥领导作用，促进高质量的研究，促进合作和跨学科方法，扩大研究基地的队伍，并通过我们的研究核心提供越来越复杂和强大的技术，帮助推动肌肉骨骼研究人员的科学研究。