Core Center for Musculoskeletal Biology and Medicine

肌肉骨骼生物学和医学核心中心

• 批准号: 8692027
• 负责人: LINDA J SANDELL
• 金额: $ 55.83万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-11 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8692027
• 关键词: Animal Experimentation; Animal Model; Award; Biological Factors; Biology; Cells; Collaborations; Degenerative polyarthritis; Disease; Five-Year Plans; Fostering; Funding; Grant; Histology; Image; Intervertebral disc structure; Leadership; Malignant Neoplasms; Mechanics; Medicine; Mentors; Metabolic Diseases; Metastatic Neoplasm to the Bone; Monitor; Muscle; Muscular Dystrophies; Musculoskeletal; Musculoskeletal Diseases; Neoplasm Metastasis; Osteoporosis; Pain; Patients; Population; Publications; Regenerative Medicine; Reporter; Research; Research Personnel; Research Technics; Science; Series; Services; Stem cells; Structure; Techniques; Technology; Tendon Injuries; Tendon structure; Testing; Tissues; Training; Training and Education; Translations; United States National Institutes of Health; Zebrafish; base; bone healing; bone strength; cartilage repair; interdisciplinary approach; interest; lost work time; member; morphometry; programs; public health relevance; ranpirnase; scoliosis; skeletal; stem; symposium

DESCRIPTION (provided by applicant): Over the past four years with the opportunity provided by the P30 CCMBM grant, our loosely organized set of musculoskeletal labs has developed into a well-respected Musculoskeletal Research Center with 75 members from 22 Departments, over 250 publications (158 in Reporter), a new facility with 12 musculoskeletal labs co-localized with the Administration and Research Cores, an active and productive Pilot and Feasibility Program, a popular Musculoskeletal Seminar Series and well-attended Annual Symposia. Our fields of interest have covered a wide variety of common musculoskeletal disorders from osteoporosis to osteoarthritis to tendon injuries to cancer. We now have $59 million in funding with $35 million from the NIH, and were recently awarded a T32 Training grant in Skeletal Metabolic Diseases. During the next five years, we plan to grow our Center to include a wider range of research interests stemming from our larger and more diverse research base, such as cancer metastasis to bone, scoliosis and intervertebral disc disease, tendon to bone healing, cartilage repair and stem cells in regenerative medicine. Our enrichment program will be expanded to include mentoring activities and training and education in specialized research techniques. The CCMBM enables the offering of many new services that will help drive the science of the research base, such as an expansion of the animal models to include zebrafish, isolation of specific populations of cells using histology and new non-invasive techniques to monitor tissue quality. Our Research Cores are: Core B: Musculoskeletal Structure and Strength, Core C: Histology and Morphometry, and Core D: Animal Models. With the help of the ICTS, we are very excited to include a new emphasis on translation of our animal research to the patient. The CCMBM will continue to provide leadership in promoting quality research, foster collaborations and interdisciplinary approaches, expand the ranks of the research base and help drive the science of musculoskeletal investigators by providing increasingly sophisticated and powerful technologies through our research cores.

描述（由申请人提供）：在过去的四年里，借助 P30 CCMBM 拨款提供的机会，我们组织松散的肌肉骨骼实验室已发展成为一个备受尊敬的肌肉骨骼研究中心，拥有来自 22 个部门的 75 名成员，发表了 250 多篇出版物（《报告》中的 158 篇），一个拥有 12 个肌肉骨骼实验室的新设施，与管理和研究核心共同定位，积极且富有成效的 试点和可行性计划、受欢迎的肌肉骨骼研讨会系列和参加人数众多的年度研讨会。我们感兴趣的领域涵盖了各种常见的肌肉骨骼疾病，从骨质疏松症到骨关节炎到肌腱损伤到癌症。我们现在拥有 5900 万美元的资金，其中 3500 万美元来自 NIH，并且最近获得了骨骼代谢疾病 T32 培训补助金。在未来五年内，我们计划扩大我们的中心，以涵盖更广泛的研究兴趣，这些研究兴趣源于我们更大、更多样化的研究基础，例如癌症骨转移、脊柱侧弯和椎间盘疾病、肌腱骨愈合、软骨修复和再生医学中的干细胞。 我们的丰富计划将扩大到包括专业研究技术的指导活动以及培训和教育。 CCMBM 能够提供许多新服务，有助于推动研究基地的科学发展，例如扩大动物模型以包括斑马鱼、使用组织学分离特定细胞群以及监测组织质量的新非侵入性技术。 我们的研究核心是：核心 B：肌肉骨骼结构和强度、核心 C：组织学和形态测量、核心 D：动物模型。在 ICTS 的帮助下，我们非常高兴能够将我们的动物研究成果转化为患者的新重点。 CCMBM 将继续在促进高质量研究、促进合作和跨学科方法、扩大研究基础队伍以及通过我们的研究核心提供日益复杂和强大的技术来帮助推动肌肉骨骼研究人员的科学方面发挥领导作用。